Literature summary for 3.4.22.B70 extracted from

Xu, Y.; Zuo, Y.; Zhang, H.; Kang, X.; Yue, F.; Yi, Z.; Liu, M.; Yeh, E.T.; Chen, G.; Cheng, J.
Induction of SENP1 in endothelial cells contributes to hypoxia-driven VEGF expression and angiogenesis (2010), J. Biol. Chem., 285, 36682-36688.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
SUMO-hypoxia-inducible factor 1 conjugate + H2O	Homo sapiens	-	SUMO + hypoxia-inducible factor 1	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9P0U3	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
umbilical vein endothelial cell	HUVEC	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
SUMO-hypoxia-inducible factor 1 conjugate + H2O	-	Homo sapiens	SUMO + hypoxia-inducible factor 1	-	?

Synonyms

Synonyms	Comment	Organism
SENP1	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	SENP1 expression can be induced by hypoxia. Induction of SENP1 expression is mediated by hypoxia-inducible factor HIF-1alpha	up

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Release 2023.1 (January 2023)