Literature summary for 3.4.22.B70 extracted from

Wu, R.; Cui, Y.; Yuan, X.; Yuan, H.; Wang, Y.; He, J.; Zhao, J.; Peng, S.
SUMO-specific protease 1 modulates cadmium-augmented transcriptional activity of androgen receptor (AR) by reversing AR SUMOylation (2014), Toxicol. Lett., 229, 405-413.

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Protein Variants

Protein Variants	Comment	Organism
additional information	silencing of SENP1 by siRNA	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
LNCaP cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
SUMOylated androgen receptor + H2O	deconjugation	Homo sapiens	androgen receptor + SUMO1	-	?

Synonyms

Synonyms	Comment	Organism
SENP1	-	Homo sapiens
SUMO-specific protease 1	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	cadmium induces SENP1 expression in LNCaP cells	up

General Information

General Information	Comment	Organism
additional information	enzyme SENP1 silencing has no influence on androgen receptor expression	Homo sapiens
physiological function	the enzyme SENP1 is involved in deconjugation of proteins, such as the androgen receptor, from small ubiquitin modifier, SUMO, proteins, a dynammic and reversible posttranslational modification. The enzyme is essential to cadmium-induced enhancement of androgen receptor activity	Homo sapiens

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Release 2023.1 (January 2023)