Cloned (Comment) | Organism |
---|---|
expression of wild-type and mutant enzymes in MEF, 293T, and 3T3-L1 cells, real-time quantitative PCR expression analysis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Sharp-1 protein + H2O | Homo sapiens | deSUMOylation by the enzyme | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9P0U3 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Sharp-1 protein + H2O | deSUMOylation by the enzyme | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SENP1 | - |
Homo sapiens |
sentrin-specific protease 1 | UniProt | Homo sapiens |
small ubiquitin-like modifier protein-specific protease 1 | - |
Homo sapiens |
SUMO protein-specific protease 1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | defects in adipocyte differentiation as well as PPARgamma expression in Senp1-/- mouse embryonic fibroblast cells induced by adipogenic stimuli. Deficiency in SUMOylation reduces Sharp-1 suppression of adipogenesis | Homo sapiens |
physiological function | the enzyme controls adipocyte differentiation. Adipocyte differentiation is regulated by a transcriptional cascade that mainly includes CCAAT/enhancer-binding protein family members and the nuclear receptor peroxisome proliferator-activated receptor gamma, PPARgamma. SENP1 is a specific de-SUMOylation protease for Sharp-1, a repressor for PPARgamma transcription and adipogenesis. SENP1 enhances adipogenesis through de-SUMOylation of Sharp-1, which then releases Sharp-1 repression of PPARgamma expression and adipocyte differentiation | Homo sapiens |