Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.B70 extracted from

  • Kaikkonen, S.; Jääskeläinen, T.; Karvonen, U.; Rytinki, M.M.; Makkonen, H.; Gioeli, D.; Paschal, B.M.; Palvimo, J.J.
    SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells (2009), Mol. Endocrinol., 23, 292-307.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
C603S SENP1C603S enhances both SUMO-1 and SUMO-2 modifications Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(SUMO-1)-androgen receptor conjugate + H2O Homo sapiens SENP1 markedly contributes to the androgen-stimulated proliferation of prostate cancer cells SUMO-1 + androgen receptor conjugate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9P0U3
-
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate cancer cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(SUMO-1)-androgen receptor conjugate + H2O
-
Homo sapiens SUMO-1 + androgen receptor conjugate
-
?
(SUMO-1)-androgen receptor conjugate + H2O SENP1 markedly contributes to the androgen-stimulated proliferation of prostate cancer cells Homo sapiens SUMO-1 + androgen receptor conjugate
-
?
additional information SENP1 is potent in removing both SUMO-1 and SUMO-2 from cellular proteins. SENP1 does not seem to differentiate between SUMO-1 and SUMO-2 Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
SENP1
-
Homo sapiens

General Information

General Information Comment Organism
physiological function SENP1 reverses the ligand-induced SUMOylation of androgen receptor and helps fine tune the cellular responses to androgens in a target promoter-selective manner. SENP1 stimulates the activity of holo-androgen receptor on compound androgen response element-containing promoters. The effects of SENP1 on androgen receptor dependent transcription are dependent on catalytic activity and require intact SUMO acceptor sites in androgen receptor, indicating that their coactivating effects are mainly due to their direct isopeptidase activity on holo-androgen receptor Homo sapiens