Protein Variants | Comment | Organism |
---|---|---|
C603S | SENP1C603S enhances both SUMO-1 and SUMO-2 modifications | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(SUMO-1)-androgen receptor conjugate + H2O | Homo sapiens | SENP1 markedly contributes to the androgen-stimulated proliferation of prostate cancer cells | SUMO-1 + androgen receptor conjugate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9P0U3 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
prostate cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(SUMO-1)-androgen receptor conjugate + H2O | - |
Homo sapiens | SUMO-1 + androgen receptor conjugate | - |
? | |
(SUMO-1)-androgen receptor conjugate + H2O | SENP1 markedly contributes to the androgen-stimulated proliferation of prostate cancer cells | Homo sapiens | SUMO-1 + androgen receptor conjugate | - |
? | |
additional information | SENP1 is potent in removing both SUMO-1 and SUMO-2 from cellular proteins. SENP1 does not seem to differentiate between SUMO-1 and SUMO-2 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SENP1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | SENP1 reverses the ligand-induced SUMOylation of androgen receptor and helps fine tune the cellular responses to androgens in a target promoter-selective manner. SENP1 stimulates the activity of holo-androgen receptor on compound androgen response element-containing promoters. The effects of SENP1 on androgen receptor dependent transcription are dependent on catalytic activity and require intact SUMO acceptor sites in androgen receptor, indicating that their coactivating effects are mainly due to their direct isopeptidase activity on holo-androgen receptor | Homo sapiens |