3.4.22.B70: SENP1 peptidase

This is an abbreviated version!
For detailed information about SENP1 peptidase, go to the full flat file.

Word Map on EC 3.4.22.B70

3.4.22.B70

desumoylation

deconjugating

senp-1

medicine

sumo-modified

senp1-mediated

drug development

ranbp2

sumo-2

diagnostics

Reaction

The enzyme catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO-1, SUMO-2 and SUMO-3 to their mature forms and deconjugation of SUMO-1, SUMO-2 and SUMO-3 from targeted proteins. Deconjugates SUMO-1 from homeodomain-interacting protein kinase 2. Deconjugates SUMO-1 from histone deacetylase 1, which decreases its transcriptional repression activity. Cleavage of Gly97-/-His98 bond in the SUMO-1 precursor with release of the propeptide His-Ser-Thr-Val. Cleavage of Gly93-/-Val94 bond in the SUMO-2 precursor with release of the propeptide Val94-Thyr. Cleavage of the Gly92-/-Val93 in the SUMO-3 precursor with release of the propeptide Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe. =

Synonyms

C13orf22l, SENP, SENP1, sentrin-specific protease 1, sentrin/SUMO-specific protease 1, small ubiquitin-like modifier protein-specific protease 1, small ubiquitin-related modifier-specific isopeptidase, SUMO isopeptidase, SUMO protease, SUMO protein-specific protease 1, SUMO-specific isopeptidase, SUMO-specific protease, SUMO-specific protease 1, ubiquitin-specific protease-like 1, USPL1

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.B70 SENP1 peptidase

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Results	in table
1	Activating Compound
3	AA Sequence
11	Application
14	Cloned(Commentary)
3	Crystallization (Commentary)
106	Disease/ Diagnostics
6	Expression
48	General Information
21	IC50 Value
47	Inhibitors
5	KM Value [mM]
19	Localization
2	Metals/Ions
1	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
46	Organism
2	pH Optimum
1	Posttranslational Modification
27	Protein Variants
6	Purification (Commentary)
1	Reaction
46	Reference
39	Source Tissue
67	Substrates and Products (Substrate)
1	Subunits
54	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
4	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.22.B70 - SENP1 peptidase

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0.0218

(2Z)-3-(naphthalen-2-yl)-N-[2-oxo-1-(2-oxoethyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]prop-2-enamide

Homo sapiens

pH and temperature not specified in the publication

717356

0.00118 - 0.00354

2-(4-chlorophenyl)-2-oxoethyl 4-(benzoylamino)benzoate

2 entries

0.05

2-(4-chlorophenyl)-2-oxoethyl 4-[(3,4-diethoxybenzoyl)amino]benzoate

Homo sapiens

Q5W0Q7

above, pH and temperature not specified in the publication

731714

0.05

2-(4-chlorophenyl)-2-oxoethyl 4-[(3,4-dimethoxybenzoyl)amino]benzoate

Homo sapiens

Q5W0Q7

above, pH and temperature not specified in the publication

731714

0.05

2-(4-chlorophenyl)-2-oxoethyl 4-[(3-aminobenzoyl)amino]benzoate

Homo sapiens

Q5W0Q7

above, pH and temperature not specified in the publication

731714

0.00174

2-(4-chlorophenyl)-2-oxoethyl 4-[(3-fluorobenzoyl)amino]benzoate

Homo sapiens

Q5W0Q7

pH and temperature not specified in the publication

731714

0.05

2-(4-chlorophenyl)-2-oxoethyl 4-[(3-hydroxybenzoyl)amino]benzoate

Homo sapiens

Q5W0Q7

above, pH and temperature not specified in the publication

731714

0.00186 - 0.00239

2-(4-chlorophenyl)-2-oxoethyl 4-[(3-methoxybenzoyl)amino]benzoate

2 entries

0.00108

2-(4-chlorophenyl)-2-oxoethyl 4-[[3-(benzyloxy)benzoyl]amino]benzoate

Homo sapiens

Q5W0Q7

pH and temperature not specified in the publication

731714

0.1

3-[(acetyloxy)amino]-N-[2-oxo-1-(2-oxoethyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]benzamide

Homo sapiens

pH and temperature not specified in the publication

717356

0.1

3-[(benzyloxy)amino]-N-[2-oxo-1-(2-oxoethyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]benzamide

Homo sapiens

pH and temperature not specified in the publication

717356

0.1

4-[(benzyloxy)amino]-N-[2-oxo-1-(2-oxoethyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]benzamide

Homo sapiens

pH and temperature not specified in the publication

717356

0.0092

benzyl (3-[[2-oxo-1-(2-oxoethyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]carbamoyl]phenyl)carbamate

Homo sapiens

pH and temperature not specified in the publication

717356

0.0155

benzyl (4-[[2-oxo-1-(2-oxoethyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]carbamoyl]phenyl)carbamate

Homo sapiens

pH and temperature not specified in the publication

717356

0.0212

naphthalen-2-yl [2-oxo-1-(2-oxoethyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]sulfamate

Homo sapiens

pH and temperature not specified in the publication

717356

0.1

phenyl [2-oxo-1-(2-oxoethyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]carbamate

Homo sapiens

pH and temperature not specified in the publication

717356

0.1

phenyl [[1-(2-hydroxyethyl)-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]carbamoyl]carbamate

Homo sapiens

pH and temperature not specified in the publication

717356

0.0272

phenyl [[2-oxo-1-(2-oxoethyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]carbamoyl]carbamate

Homo sapiens

pH and temperature not specified in the publication

717356

0.1

phenyl [[2-oxo-1-(4-oxobutyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]carbamoyl]carbamate

Homo sapiens

pH and temperature not specified in the publication

717356