Literature summary for 3.4.22.B70 extracted from

Kim, Y.H.; Sung, K.S.; Lee, S.J.; Kim, Y.O.; Choi, C.Y.; Kim, Y.
Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1 (2005), FEBS Lett., 579, 6272-6278.

Search for more literature for 3.4.22.B70

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	desumoylation is enhanced either by the forced translocation of SENP1 into the nucleus or by the SENP1 NES (nuclear export sequence) mutant	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
C603A	the mutant is unable to desumoylate the (SUMO-1)-homeodomain-interacting protein kinase 2 conjugate	Homo sapiens
additional information	the deletion of the C-terminal portion to aa 634 induces the nuclear localization of SENP1. Further deletion to aa 574 results in the diffused localization of SENP1 both to the nucleus and the cytoplasm. This result suggests that there might be a motif for the nuclear localization of SENP1 in the region from aa 574 to 633	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	SENP1 shuttles between the cytoplasm and the nucleus. SENP1 contains the nuclear export sequence (NES) within the extreme carboxyl-terminal region, and SENP1 is exported to the cytoplasm in a NES-dependent manner	Homo sapiens	5737	-
nucleus	SENP1 shuttles between the cytoplasm and the nucleus. SENP1 contains the nuclear export sequence (NES) within the extreme carboxyl-terminal region, and SENP1 is exported to the cytoplasm in a NES-dependent manner. As sumoylations are nuclear events and most SUMO-conjugates are located within the nucleus, it appears that SENP1 might find its cellular targets subsequent to its nuclear relocalization	Homo sapiens	5634	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	the enzyme effectively removes SUMO-1 moiety, in the presence of Ca2+ rather than Mn2+, from the sumoylated homeodomain-interacting protein kinase 2 conjugate	Homo sapiens
Mn2+	the enzyme effectively removes SUMO-1 moiety, in the presence of Ca2+ rather than Mn2+, from the sumoylated homeodomain-interacting protein kinase 2 conjugate	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(SUMO-1)-homeodomain-interacting protein kinase 2 conjugate + H2O	Homo sapiens	desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) may be regulated by the cytoplasmic-nuclear shuttling of SENP1. Desumoylation induces dissociation of homeodomain-interacting protein kinase 2 conjugate from nuclear bodies	SUMO-1 + homeodomain-interacting protein kinase 2 conjugate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9P0U3	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(SUMO-1)-homeodomain-interacting protein kinase 2 conjugate + H2O	-	Homo sapiens	SUMO-1 + homeodomain-interacting protein kinase 2 conjugate	-	?
(SUMO-1)-homeodomain-interacting protein kinase 2 conjugate + H2O	desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) may be regulated by the cytoplasmic-nuclear shuttling of SENP1. Desumoylation induces dissociation of homeodomain-interacting protein kinase 2 conjugate from nuclear bodies	Homo sapiens	SUMO-1 + homeodomain-interacting protein kinase 2 conjugate	-	?

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Release 2023.1 (January 2023)