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Literature summary for 3.4.22.B70 extracted from

  • Chow, K.H.; Elgort, S.; Dasso, M.; Powers, M.A.; Ullman, K.S.
    The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function (2014), Mol. Biol. Cell, 25, 160-168.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
nuclear envelope
-
 Homo sapiens 5635
-
nuclear pore complex
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
SENP1
-
 Homo sapiens
sentrin/SUMO-specific protease 1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction differential localization of nucleoporins upon codepletion of SENP1 and SENP2 in HeLa cells, immunohistochemic analysis, overview Homo sapiens
physiological function SENP1, as well as SENP2, regulates the proper localization of nucleoporins, overview. The enzyme interacts with the nucleoporin Nup153 via a dual interface that includes a bridging interaction with the soluble transport receptor importin beta and a SUMO-mediated mechanism. SENP1 and SENP2 are not required for localization of the transmembrane proteins nucleoporin POM121 and inner nu­clear envelope protein Sun1 or expansion of the interphase nuclear envelope Homo sapiens