Literature summary for 3.4.22.B70 extracted from

Bailey, D.; O'Hare, P.
Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1 (2004), J. Biol. Chem., 279, 692-703.

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Protein Variants

Protein Variants	Comment	Organism
C603S	inactive mutant enzyme. C603S is exclusively nuclear in comparison with the wild-type SENP1, which is consistently present in the cytoplasm, albeit t low steady state levels. SENP1 is itself a target for SUMO-1 modification but that this modification is normally rapidly reversed by an autocatalytic activity removing the SUMO-1, with little of the modified form accumulating. In the mutant SENP1 (C603S), the absence of proteolytic activity resul in the detection of the conjugated form	Homo sapiens
additional information	very few cells express the exogenous SENP1 436-644 core domain construct, and in any positive cells expression is at extremely low levels. The SENP1 436-644 C603S construct, however, is readily detected, often with very high levels of expression	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	C603S is exclusively nuclear in comparison with the wild-type SENP1, which is consistently present in the cytoplasm, albeit at low steady state levels	Homo sapiens	5737	-
nucleus	C603S is exclusively nuclear in comparison with the wild-type SENP1, which is consistently present in the cytoplasm, albeit at low steady state levels. Presence of a single nonconsensus nuclear localization signal within the N-terminus of the protein. Residues within the predicted NLS1 region around positions 170-180 are critical for the nuclear localization of SENP1. SENP1 localization may be influenced by the expression of proteins that are targets of SUMO-1 modification, such as HDAC4 and PML, which affects the relative levels and localization of SUMO-1 conjugates within the cell	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
sumoylation	SENP1 is itself a target for SUMO-1 modification but that this modification is normally rapidly reversed by an autocatalytic activity removing the SUMO-1, with little of the modified form accumulating. In the mutant SENP1 (C603S), the absence of proteolytic activity resulted in the detection of the conjugated form	Homo sapiens

Synonyms

Synonyms	Comment	Organism
sentrin-specific protease 1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	modification of proteins by small ubiquitin-like modifier (SUMO) plays an important role in the function, compartmentalization, and stability of target proteins, contributing to the regulation of diverse processes. SUMO-1 modification can be regulated not only at the level of conjugation, it may also be reversed by a class of proteases known as the SUMO-specific proteases	Homo sapiens

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Release 2023.1 (January 2023)