Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P59110 | - |
- |
General Information | Comment | Organism |
---|---|---|
malfunction | SENP1 knockdown impairs exocytosis at stimulatory glucose levels and blunts glucose-dependent insulin secretion from mouse and human islets. SENP1 overexpression also disrupts the association of SUMO1 with synaptotagmin VII and mimics the effect of glucose to enhance exocytosis | Mus musculus |
physiological function | SENP1, is required for glucose-dependent insulin secretion. SUMOylation acutely regulates insulin secretion by the direct and reversible inhibition of beta-cell exocytosis in response to intracellular Ca(2+) elevation | Mus musculus |