Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(SUMO-1)-K2P1 potassium channel + H2O | Homo sapiens | silent K2P1 channels in excised plasma membrane patches are activated by SENP1 | SUMO-1 + K2P1 potassium channel | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9P0U3 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(SUMO-1)-K2P1 potassium channel + H2O | silent K2P1 channels in excised plasma membrane patches are activated by SENP1 | Homo sapiens | SUMO-1 + K2P1 potassium channel | - |
? | |
(SUMO-1)-K2P1 subunit of potassium channel + H2O | SUMO1 is conjugated to the epsilon-amino group of Lys274 of the K2P1 potassium channel. When mutated to Gln, Arg, Glu, Asp, Cys, or Ala, the channels are constitutively active and insensitive to SUMO1 and SENP1. Wild-type channels in plasma membrane have two K2P1 subunits and assemble with two SUMO1 monomers. Although channels engineered with one Lys274 site carry just one SUMO1 they are activated and silenced by SENP1 and SUMO1 like wild-type channels | Homo sapiens | SUMO-1 + K2P1 subunit of potassium channel | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SUMO isopeptidase | - |
Homo sapiens |