3.4.22.60: caspase-7

This is an abbreviated version!
For detailed information about caspase-7, go to the full flat file.

Word Map on EC 3.4.22.60

3.4.22.60

caspase-3

bcl-2

parp

anti-apoptotic

pro-apoptotic

executioner

necrosis

polyadp-ribose

caspase-dependent

annexin

tunel

survivin

cyclin

apoptosis-inducing

adp-ribose

apoptosis-related

bid

xiap

calpains

pan-caspase

jnk

cdk2

hoechst

caspase-mediated

antiproliferative

apaf-1

z-vad-fmk

caspase-3-like

pyroptosis

ac-devd-cho

apoptosome

template-based

puma

trail-induced

devd

caspase-3-deficient

mitochondria-dependent

procaspase

apoptosis-associated

molecular biology

casp10

spinocerebellar

sub-g1

medicine

Reaction

strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-/- =

Synonyms

apoptotic protease Mch-3, C14.004, Casp-7, Casp7, caspase 7, caspase-7, CMH-1, cystein aspartic-specific protease-7, DEVDase, ICE-LAP3, ICE-like apoptotic protease 3, LICE2 cysteine protease, More, SCA-2, SREBP cleavage activity 2

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.60 caspase-7

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Results	in table
27	Activating Compound
57	AA Sequence
14	Application
1	CAS Registry Number
28	Cloned(Commentary)
4	Crystallization (Commentary)
827	Disease/ Diagnostics
1	Expression
15	General Information
29	IC50 Value
79	Inhibitors
17	kcat/KM [mM/s]
11	Ki Value [mM]
35	KM Value [mM]
17	Localization
8	Molecular Weight [Da]
54	Natural Substrates/ Products (Substrates)
223	Organism
117	PDB ID
8	pH Optimum
1	pH Range
16	Posttranslational Modification
31	Protein Variants
14	Purification (Commentary)
2	Reaction
1	Reaction Type
84	Reference
123	Source Tissue
1	Specific Activity [micromol/min/mg]
141	Substrates and Products (Substrate)
8	Subunits
24	Synonyms
4	Temperature Optimum [°C]
27	Turnover Number [1/s]

Source Tissue

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of the Enzyme Summary Page.

Source Tissue on EC 3.4.22.60 - caspase-7

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endometrial carcinoma cell line

primary

B cells derived from cavity-based B cell lymphoma

717785

B-lymphoma cell

Homo sapiens

B cells derived from cavity-based B cell lymphoma

and gills, second highest expression level

752586

bone

Mus musculus

the activated form of caspase-7 is detected from the beginning of ossification during embryonic development and persists postnatally in alveolar and mandibular bones as well as long bones of limbs

conjunctival cell

egg

endometrioid carcinoma cell

and blood, second highest expression level

endometrial carcinoma cell line

697139

HEC-1-B cell

Homo sapiens

endometrial carcinoma cell line

ovarian epithelial cell line

697139

HOSE 17-1 cell

Homo sapiens

ovarian epithelial cell line

697139

HOSE 6-3 cell

Homo sapiens

ovarian epithelial cell line

monolayer cell culture

monolayer cell culture

699310

kidney

3 entries

Leydig cell tumor cell

a glioma cell line

669509, 679154, 700944, 717785

MDA-MB-231 cell

Homo sapiens

monolayer cell culture

ovarian carcinoma cell line

697139

OVCA-429 cell

Homo sapiens

ovarian carcinoma cell line

697139

OVCA-433 cell

Homo sapiens

ovarian carcinoma cell line

697139

OVCAR-3 cell

Homo sapiens

ovarian carcinoma cell line

endometrial carcinoma cell line

697139

sciatic nerve

Rattus norvegicus

increased expression of caspase-7 mRNA in the dorsal horn spinal cord by 3 days post-chronic constrictive injury

ovarian carcinoma cell line

stage 62 tadpole tail

647422

tail

Xenopus laevis

stage 62 tadpole tail

precursor neurons

additional information

4 entries