3.4.22.60: caspase-7
This is an abbreviated version!
For detailed information about caspase-7, go to the full flat file.
Word Map on EC 3.4.22.60
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3.4.22.60
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caspase-3
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bcl-2
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parp
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anti-apoptotic
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pro-apoptotic
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executioner
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necrosis
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polyadp-ribose
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caspase-dependent
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annexin
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tunel
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survivin
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cyclin
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apoptosis-inducing
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adp-ribose
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apoptosis-related
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bid
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xiap
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calpains
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pan-caspase
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jnk
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cdk2
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hoechst
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caspase-mediated
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antiproliferative
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apaf-1
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z-vad-fmk
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caspase-3-like
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pyroptosis
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ac-devd-cho
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apoptosome
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template-based
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puma
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trail-induced
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devd
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caspase-3-deficient
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mitochondria-dependent
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procaspase
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apoptosis-associated
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molecular biology
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casp10
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spinocerebellar
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sub-g1
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medicine
- 3.4.22.60
- caspase-3
- bcl-2
- parp
-
anti-apoptotic
-
pro-apoptotic
-
executioner
- necrosis
-
polyadp-ribose
-
caspase-dependent
-
annexin
-
tunel
- survivin
- cyclin
-
apoptosis-inducing
- adp-ribose
-
apoptosis-related
- bid
- xiap
- calpains
-
pan-caspase
- jnk
- cdk2
-
hoechst
-
caspase-mediated
-
antiproliferative
- apaf-1
- z-vad-fmk
-
caspase-3-like
-
pyroptosis
- ac-devd-cho
- apoptosome
-
template-based
- puma
-
trail-induced
- devd
-
caspase-3-deficient
-
mitochondria-dependent
-
procaspase
-
apoptosis-associated
- molecular biology
- casp10
-
spinocerebellar
-
sub-g1
- medicine
Reaction
strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-/- =
Synonyms
apoptotic protease Mch-3, C14.004, Casp-7, Casp7, caspase 7, caspase-7, CMH-1, cystein aspartic-specific protease-7, DEVDase, ICE-LAP3, ICE-like apoptotic protease 3, LICE2 cysteine protease, More, SCA-2, SREBP cleavage activity 2
ECTree
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General Information
General Information on EC 3.4.22.60 - caspase-7
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malfunction
physiological function
additional information
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active caspase-7 colocalizes with internalized TNF-R1 receptosomes. TNF-induced caspase-7 activation takes place exclusively within TNF receptosomes
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deletion of caspase-7 inhibits TNF-induced cleavage and activation of A-SMase
malfunction
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depletion of caspase-7 from the cytoplasmic extracts of valproate-induced BCBL-1 cells reduces the cleavage of ORF57, and inhibition of caspase-7 activity promotes the expression of ORF59
malfunction
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caspase-7-deficient MEF cells are not resistance to intrinsic cell death, but remain attached to the extracellular matrix
malfunction
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caspase-7-deficient mice still possesses apoptotic cells in the primary enamel knot in a similar distribution to the wild type
malfunction
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enzyme-deficient mice show a significant decrease in mineral density of endochondral bones
malfunction
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mice lacking caspase-7 and its macrophages allow substantial Legionella pneumophila replication. This permissiveness of caspase-7-deficient macrophages to the intracellular pathogen is due to defective delivery of the organism to the lysosome and to delayed cell death during early stages of infection
malfunction
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there is a significant decrease in the amount of mineralized tissue in caspase-7 knockout mice
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caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 in the cytoplasm confers a cellular function against viral lytic gene expression. But only initiator caspase-8, EC 3.4.22.61, is triggered in BCBL-1 cells with lytic KSHV induction by valproate, along with cleavage of expressed ORF57. Caspase-7 is an essential caspase in the cleavage of KSHV ORF57 and plays a key role in ORF57 cleavage in BCBL-1 cells during KSHV lytic infection
physiological function
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caspase-7 activation is sufficient to start apoptosis, but it requires mitochondrial contribution to fully commit
physiological function
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caspase-7 influences intramembranous and endochondral bone development
physiological function
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caspase-7 is directly involved in functional cell differentiation and regulation of the mineralization of dental matrices
physiological function
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caspase-7 is not essential for apoptosis in the primary enamel knot but possibly fulfills non-apoptotic functions in tooth development
physiological function
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caspase-7 is required for apoptotic cell detachment and contributes to reactive oxygen species production
physiological function
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caspase-7 plays a role in host defense against Legionella pneumophila. Caspase-7 activation during Legionella pneumophila infection restricts growth by promoting early macrophage death and efficient delivery of the organism to the lysosome