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Disease on EC 3.4.22.60 - caspase-7

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Potentially Functional Polymorphisms in the CASP7 Gene Contribute to Gastric Adenocarcinoma Susceptibility in an Eastern Chinese Population.
Protein and phosphoprotein levels in glioma and adenocarcinoma cell lines grown in normoxia and hypoxia in monolayer and three-dimensional cultures.
Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells.
Variant TP53BP1 rs560191 G>C is associated with risk of gastric cardia adenocarcinoma in a Chinese Han population.
Adenocarcinoma of Lung
Stable silencing of ROR1 regulates cell cycle, apoptosis, and autophagy in a lung adenocarcinoma cell line.
Alzheimer Disease
A loss of function variant in CASP7 protects against Alzheimer's disease in homozygous APOE ?4 allele carriers.
A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease.
Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 and TG genes associated with Alzheimer's disease in Caribbean Hispanic individuals.
Arthritis
Chondroitin-4-sulphate inhibits NF-kB translocation and caspase activation in collagen-induced arthritis in mice.
Arthritis, Rheumatoid
Caspase 7 influences susceptibility to rheumatoid arthritis.
Genetic and expression analysis of CASP7 gene in a European Caucasian population with rheumatoid arthritis.
Ataxia
Case control analysis of repeat expansion size in ataxia.
Late-onset SCA2: 33 CAG repeats are sufficient to cause disease.
Mutation at the SCA17 locus is not a common cause of parkinsonism.
Overwhelming genetic heterogeneity and exhausting molecular diagnostic process in chronic and progressive ataxias: facing it up with an algorithm, a gene, a panel at a time.
Spastic paraplegia, ataxia, mental retardation (SPAR): a novel genetic disorder.
Synapses in the hereditary ataxias.
Ataxia Telangiectasia
Epigenetic inactivation of BCL6B, a novel functional tumour suppressor for gastric cancer, is associated with poor survival of gastric cancer.
JS-K, a nitric oxide prodrug, induces DNA damage and apoptosis in HBV-positive hepatocellular carcinoma HepG2.2.15 cell.
Brain Injuries
Caspase 7: increased expression and activation after traumatic brain injury in rats.
Necroptotic-Apoptotic Regulation in an Endothelin-1 Model of Cerebral Ischemia.
Brain Injuries, Traumatic
Caspase 7: increased expression and activation after traumatic brain injury in rats.
Proteolysis consistent with activation of caspase-7 after severe traumatic brain injury in humans.
Brain Ischemia
[Mechanism of Chuanxiong Rhizoma-Paeoniae Radix Rubra drug pair on intervention of cerebral ischemia based on network pharmacology-molecular docking].
Breast Neoplasms
2-aryl benzimidazole conjugate induced apoptosis in human breast cancer MCF-7 cells through caspase independent pathway.
Anti-miR-203 Upregulates SOCS3 Expression in Breast Cancer Cells and Enhances Cisplatin Chemosensitivity.
Anticancer Potential of Silibinin Loaded Polymeric Nanoparticles against Breast Cancer Cells: Insight into the Apoptotic Genes Targets.
Apoptosis induction in human breast cancer (MCF-7) cells by a novel venom L-amino acid oxidase (Rusvinoxidase) is independent of its enzymatic activity and is accompanied by caspase-7 activation and reactive oxygen species production.
Biochemical pathways mediated by KLK6 protease in breast cancer.
Biphasic dose-dependent effect of lithium chloride on survival of human hormone-dependent breast cancer cells (mcf-7).
Blockade of GRP78 sensitizes breast cancer cells to microtubules-interfering agents that induce the unfolded protein response.
Efficacy of sulforaphane is mediated by p38 MAP kinase and caspase-7 activations in ER-positive and COX-2-expressed human breast cancer cells.
Gamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells.
ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis.
Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047.
Limonoids and their anti-proliferative and anti-aromatase properties in human breast cancer cells.
Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers.
New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation.
Optical nanobiosensor for monitoring an apoptotic signaling process in a single living cell following photodynamic therapy.
Overexpression of caspase 7 is ER? dependent to affect proliferation and cell growth in breast cancer cells by targeting p21(Cip).
Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines.
PPAR?-inactive ?2-troglitazone independently triggers ER stress and apoptosis in breast cancer cells.
Prioritizing disease biomarkers using functional module based network analysis: A multilayer consensus driven scheme.
Traumatic acid toxicity mechanisms in human breast cancer MCF-7?cells.
Up-regulation of gamma-synuclein contributes to cancer cell survival under endoplasmic reticulum stress.
YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells.
Bulbo-Spinal Atrophy, X-Linked
Cerebellar allografts survive and transiently alleviate ataxia in a transgenic model of spinocerebellar ataxia type-1.
Transglutaminase-dependent formation of protein aggregates as possible biochemical mechanism for polyglutamine diseases.
Carcinogenesis
Caspase expression in oral squamous cell carcinoma.
Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17.
miR-224 Is Significantly Upregulated and Targets Caspase-3 and Caspase-7 During Colorectal Carcinogenesis.
Prediction and Analysis of Skin Cancer Progression using Genomics Profiles of Patients.
[Expression of survivin and caspase-3 in non-Hodgkin's lymphoma and their clinical significance]
[Expressions of survivin and caspase-3 in human non-small cell lung cancer and their relationship with cell apoptosis.]
Carcinoma
A compound isolated from Schisandra chinensis induces apoptosis.
Assessment of apoptosis by immunohistochemistry to active caspase-3, active caspase-7, or cleaved PARP in monolayer cells and spheroid and subcutaneous xenografts of human carcinoma.
Caspase 7 downregulation as an immunohistochemical marker of colonic carcinoma.
Combination of Pitavastatin and melatonin shows partial antineoplastic effects in a rat breast carcinoma model.
Cytochrome c is involved in Fas-mediated apoptosis of prostatic carcinoma cell lines.
Expression and Prognostic Significance of Livin, Caspase-3, and Ki-67 in the Progression of Human Ampullary Carcinoma.
Fas-mediated apoptosis in human prostatic carcinoma cell lines occurs via activation of caspase-8 and caspase-7.
Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17.
Inactivating mutations of CASPASE-7 gene in human cancers.
Inhibition of human pancreatic cell line MIA PaCa2 proliferation by HA-But, a hyaluronic butyric ester: a preliminary report.
Investigating cytokinesis failure as a strategy in cancer therapy.
Loss of caspase 7 expression is associated with poor prognosis in renal cell carcinoma clear cell subtype.
Melatonin potentiates the anti-tumour effect of pravastatin in rat mammary gland carcinoma model.
Role of IRF-1 and caspase-7 in IFN-gamma enhancement of Fas-mediated apoptosis in ACHN renal cell carcinoma cells.
Carcinoma, Basal Cell
Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17.
Carcinoma, Ductal
Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines.
Carcinoma, Hepatocellular
Functional characterization of hepatoma-specific stem cell antigen-2.
Identification of components of grape powder with anti-apoptotic effects.
The anti-cancer flavonoid chrysin induces the unfolded protein response in hepatoma cells.
Carcinoma, Non-Small-Cell Lung
Association of CASP7 Polymorphisms and Survival of Non-Small-Cell Lung Cancer Patients with Platinum-Based Chemotherapy Treatment.
Prognostic assessment of apoptotic gene polymorphisms in non-small cell lung cancer in Chinese.
Carcinoma, Renal Cell
Loss of caspase 7 expression is associated with poor prognosis in renal cell carcinoma clear cell subtype.
Role of IRF-1 and caspase-7 in IFN-gamma enhancement of Fas-mediated apoptosis in ACHN renal cell carcinoma cells.
Cardiomyopathies
A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathways.
Apoptotic versus autophagic cell death in heart failure.
caspase-7 deficiency
Caspase 7 downregulation as an immunohistochemical marker of colonic carcinoma.
Caspase-7 deficiency in Chinese hamster ovary cells reduces cell proliferation and viability.
Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival.
NLRP3 Inflammasome Deficiency Protects Against Microbial Sepsis via Increased Lipoxin B4 Synthesis.
Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue.
Chondrosarcoma
MLN4924, a Protein Neddylation Inhibitor, Suppresses the Growth of Human Chondrosarcoma through Inhibiting Cell Proliferation and Inducing Endoplasmic Reticulum Stress-Related Apoptosis.
Coinfection
bta-miR-29b attenuates apoptosis by directly targeting caspase-7 and NAIF1 and suppresses bovine viral diarrhea virus replication in MDBK cells.
Colonic Neoplasms
2'-Hydroxycinnamaldehyde induces apoptosis through HSF1-mediated BAG3 expression.
Antioxidants decrease the apoptotic effect of 5-Fu in colon cancer by regulating Src-dependent caspase-7 phosphorylation.
Caspase 7 downregulation as an immunohistochemical marker of colonic carcinoma.
Evidence of cell damage induced by major components of a diet-compatible mixture of oxysterols in human colon cancer CaCo-2 cell line.
Immune-Related Prognostic Model in Colon Cancer: A Gene Expression-Based Study.
Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth.
Regulation of caspase expression and apoptosis by adenomatous polyposis coli.
Short-chain fatty acids induced autophagy serves as an adaptive strategy for retarding mitochondria-mediated apoptotic cell death.
Tissue factor-factor VIIa regulates interleukin-8, tissue factor and caspase-7 expression in SW620 cells through protease-activated receptor-2 activation.
Colorectal Neoplasms
miR-224 Is Significantly Upregulated and Targets Caspase-3 and Caspase-7 During Colorectal Carcinogenesis.
RIPK1 and CASP7 polymorphism as prognostic markers for survival in patients with colorectal cancer after complete resection.
Targeting SREBP1 chemosensitizes colorectal cancer cells to gemcitabine by caspase-7 upregulation.
Congenital Abnormalities
Calcium Alleviates Fluoride-Induced Bone Damage by Inhibiting Endoplasmic Reticulum Stress and Mitochondrial Dysfunction.
Dementia
Mutation at the SCA17 locus is not a common cause of parkinsonism.
Diabetes Mellitus, Type 1
Caspase 7 is a positional candidate gene for IDDM 17 in a Bedouin Arab family.
Dystonia
Mutation at the SCA17 locus is not a common cause of parkinsonism.
Endometrial Hyperplasia
Autophagy in the physiological endometrium and cancer.
Endometrial Neoplasms
Autophagy in the physiological endometrium and cancer.
Polymorphisms and haplotypes in the caspase-3, caspase-7, and caspase-8 genes and risk for endometrial cancer: a population-based, case-control study in a Chinese population.
Endotoxemia
Caspase-7: A protease involved in apoptosis and inflammation.
Fibrosarcoma
Effect of TERT on the growth of fibrosarcoma via caspase-3, survivin and PKB.
Kringle 5 of human plasminogen induces apoptosis of endothelial and tumor cells through surface-expressed glucose-regulated protein 78.
Glaucoma
Caspase-7: a critical mediator of optic nerve injury-induced retinal ganglion cell death.
Glioblastoma
Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma.
The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.
Glioma
Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma.
GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis.
Pre-treatment or Post-treatment of Human Glioma Cells With BIX01294, the Inhibitor of Histone Methyltransferase G9a, Sensitizes Cells to Temozolomide.
Protein and phosphoprotein levels in glioma and adenocarcinoma cell lines grown in normoxia and hypoxia in monolayer and three-dimensional cultures.
Tumor therapy mediated by lentiviral expression of shBcl-2 and S-TRAIL.
Two different mechanisms of apoptosis resistance observed in interferon-beta induced apoptosis of human glioma cells.
Hearing Loss, Noise-Induced
Role of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population.
Hepatitis B
Hepatitis B vaccine induces apoptotic death in Hepa1-6 cells.
Huntington Disease
Cerebellar allografts survive and transiently alleviate ataxia in a transgenic model of spinocerebellar ataxia type-1.
DNA damage induced by polyglutamine-expanded proteins.
Increased caspase-2, calpain activations and decreased mitochondrial complex II activity in cells expressing exogenous huntingtin exon 1 containing CAG repeat in the pathogenic range.
Transglutaminase-dependent formation of protein aggregates as possible biochemical mechanism for polyglutamine diseases.
Infections
Caspase-3-like proteases are activated by infection but are not required for replication of vesicular stomatitis virus.
Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection.
Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression.
Caspase-Mediated Cleavage of Human Cortactin during Influenza A Virus Infection Occurs in Its Actin-Binding Domains and Is Associated with Released Virus Titres.
Enterovirus 71 induces apoptosis of SH?SY5Y human neuroblastoma cells through stimulation of endogenous microRNA let-7b expression.
Exoenzyme Y induces extracellular active caspase-7 accumulation independent from apoptosis: modulation of transmissible cytotoxicity.
HCV Induces Telomerase Reverse Transcriptase, Increases Its Catalytic Activity, and Promotes Caspase Degradation in Infected Human Hepatocytes.
Membrane damage during Listeria monocytogenes infection triggers a caspase-7 dependent cytoprotective response.
Selenium Plays a Protective Role in Staphylococcus aureus-Induced Endometritis in the Uterine Tissue of Rats.
The Acinetobacter trimeric autotransporter adhesin Ata controls key virulence traits of Acinetobacter baumannii.
The JAK/STAT3 signaling pathway mediates inhibition of host cell apoptosis by Chlamydia psittaci infection.
Inflammatory Bowel Diseases
miR-224 Is Significantly Upregulated and Targets Caspase-3 and Caspase-7 During Colorectal Carcinogenesis.
Influenza, Human
Influenza virus induces apoptosis via BAD-mediated mitochondrial dysregulation.
Interaction of influenza A virus M1 matrix protein with caspases.
Ischemic Stroke
Association of genetic polymorphisms in CASP7 with risk of ischaemic stroke.
Legionnaires' Disease
Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection.
Leukemia
Anticancer activity of a synthetic peptide derived from harmoniasin, an antibacterial peptide from the ladybug Harmonia axyridis.
Association between CASP7 and CASP14 genetic polymorphisms and the risk of childhood leukemia.
Bifidobacterium breve - HT-29 cell line interaction: modulation of TNF-? induced gene expression.
Leukoplakia
Sequence and expression variations in 23 genes involved in mitochondrial and non-mitochondrial apoptotic pathways and risk of oral leukoplakia and cancer.
Lung Neoplasms
A literature-based systematic HuGE review and meta-analysis show that CASP gene family polymorphisms are associated with risk of lung cancer.
Albanol B from Mulberries Exerts Anti-Cancer Effect through Mitochondria ROS Production in Lung Cancer Cells and Suppresses In Vivo Tumor Growth.
ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features.
Association of CASP7 Polymorphisms and Survival of Non-Small-Cell Lung Cancer Patients with Platinum-Based Chemotherapy Treatment.
MicroRNA-224 is implicated in lung cancer pathogenesis through targeting caspase-3 and caspase-7.
Polymorphisms in the caspase genes and the risk of lung cancer.
Polymorphisms in the Caspase7 gene and the risk of lung cancer.
Prognostic assessment of apoptotic gene polymorphisms in non-small cell lung cancer in Chinese.
Lymphoma
Absence of CASP7 and CASP8 mutation in gastrointestinal lymphomas.
Anti-CD20 antibody (IDEC-C2B8, rituximab) enhances efficacy of cytotoxic drugs on neoplastic lymphocytes in vitro: role of cytokines, complement, and caspases.
Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression.
Endoplasmic Reticulum Stress and Neurodegeneration in Experimental Cerebral Malaria.
Implication of calpain in caspase activation during B cell clonal deletion.
Mitochondria-dependent caspase-9 activation is necessary for antigen receptor-mediated effector caspase activation and apoptosis in WEHI 231 lymphoma cells.
Synergistic anticancer effects of bufalin and sorafenib by regulating apoptosis associated proteins.
Lymphoma, B-Cell
Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression.
Deficiency of dietary pyridoxine disturbed the intestinal physical barrier function of young grass carp (Ctenopharyngodon idella).
Endoplasmic Reticulum Stress and Neurodegeneration in Experimental Cerebral Malaria.
Implication of calpain in caspase activation during B cell clonal deletion.
MicroRNA-181a suppresses norethisterone-promoted tumorigenesis of breast epithelial MCF10A cells through the PGRMC1/EGFR-PI3K/Akt/mTOR signaling pathway.
Naringin inhibits ovarian tumor growth by promoting apoptosis: An in vivo study.
Suppression of tumor cell proliferation and migration by human umbilical cord mesenchymal stem cells: A possible role for apoptosis and Wnt signaling.
The Inhibitory Effect of Cordycepin on the Proliferation of MCF-7 Breast Cancer Cells, and its Mechanism: An Investigation Using Network Pharmacology-Based Analysis.
Machado-Joseph Disease
Transglutaminase-dependent formation of protein aggregates as possible biochemical mechanism for polyglutamine diseases.
Medulloblastoma
Cleaved caspase-3, caspase-7 and poly (ADP-ribose) polymerase are complementarily but differentially expressed in human medulloblastomas.
The alkylphospholipid perifosine induces apoptosis and p21-mediated cell cycle arrest in medulloblastoma.
Melanoma
Cisplatin-induced apoptosis in melanoma cells: role of caspase-3 and caspase-7 in Apaf-1 proteolytic cleavage and in execution of the degradative phases.
Livin/melanoma inhibitor of apoptosis protein as a potential therapeutic target for the treatment of malignancy.
Prediction and Analysis of Skin Cancer Progression using Genomics Profiles of Patients.
Mouth Neoplasms
MicroRNA-205 suppresses the oral carcinoma oncogenic activity via down-regulation of Axin-2 in KB human oral cancer cell.
Sequence and expression variations in 23 genes involved in mitochondrial and non-mitochondrial apoptotic pathways and risk of oral leukoplakia and cancer.
Multiple System Atrophy
Structural and immunocytochemical features of olivopontocerebellar atrophy caused by the spinocerebellar ataxia type 1 (SCA-1) mutation define a unique phenotype.
Myoclonic Epilepsies, Progressive
Cerebellar allografts survive and transiently alleviate ataxia in a transgenic model of spinocerebellar ataxia type-1.
Neoplasm Metastasis
Biochemical pathways mediated by KLK6 protease in breast cancer.
Gene signature based on degradome-related genes can predict distal metastasis in cervical cancer patients.
Neoplasms
A Combined ULBP2 and SEMA5A Expression Signature as a Prognostic and Predictive Biomarker for Colon Cancer.
A novel diterpene suppresses CWR22Rv1 tumor growth in vivo through antiproliferation and proapoptosis.
A single amino acid substitution confers B-cell clonogenic activity to the HIV-1 matrix protein p17.
Active caspases and cleaved cytokeratins are sequestered into cytoplasmic inclusions in TRAIL-induced apoptosis.
Anti-neoplastic activity of Amblyomma sculptum, Amblyomma parvum and Rhipicephalus sanguineus tick saliva on breast tumor cell lines.
Antineoplastic effects of Chlorella pyrenoidosa in the breast cancer model.
Antitumoral Effects of Melissa officinalis on Breast Cancer in Vitro and in Vivo.
Autophagy in the physiological endometrium and cancer.
Black tea polyphenols restrict benzopyrene-induced mouse lung cancer progression through inhibition of Cox-2 and induction of caspase-3 expression.
Calpain-1 cleaves and activates caspase-7.
Canavanine augments proapoptotic effects of arginine deprivation in cultured human cancer cells.
Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells.
Caspase 7 can cleave tumor necrosis factor receptor-I (p60) at a non-consensus motif, in vitro.
Caspase 7 downregulation as an immunohistochemical marker of colonic carcinoma.
Caspase polymorphisms and prognosis of hepatocellular carcinoma.
Caspase-7: A protease involved in apoptosis and inflammation.
Chondroitin-4-sulphate reduced oxidative injury in caerulein-induced pancreatitis in mice: the involvement of NF-kappaB translocation and apoptosis activation.
Cleaved caspase-3, caspase-7 and poly (ADP-ribose) polymerase are complementarily but differentially expressed in human medulloblastomas.
Compound 21 and Telmisartan combination mitigates type 2 diabetic nephropathy through amelioration of caspase mediated apoptosis.
Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells.
Design and Synthesis of New CDK2 Inhibitors Containing Thiazolone and Thiazolthione Scafold with Apoptotic Activity.
Design, synthesis and biological evaluation of cinnamic acyl shikonin derivatives.
Development and therapeutic options for the treatment of raloxifene-stimulated breast cancer in athymic mice.
Discovery of New H2S Releasing Phosphordithioates and 2,3-Dihydro-2-phenyl-2-sulfanylenebenzo[d][1,3,2]oxazaphospholes with Improved Antiproliferative Activity.
Effects of chlorella on activities of protein tyrosine phosphatases, matrix metalloproteinases, caspases, cytokine release, B and T cell proliferations, and phorbol ester receptor binding.
Effects of matrine in combination with cisplatin on liver cancer.
Effects of short-term finasteride on apoptotic factors and androgen receptors in prostate cancer cells.
Epigenetic inactivation of BCL6B, a novel functional tumour suppressor for gastric cancer, is associated with poor survival of gastric cancer.
Estrone-salicylaldehyde N-methylated thiosemicarbazone hybrids and their copper complexes: solution structure, stability and anticancer activity in tumour spheroids.
Expression of caspase-3 and -7 does not correlate with the extent of apoptosis in primary breast carcinomas.
Failure of activation of caspase-9 induces a higher threshold for apoptosis and cisplatin resistance in testicular cancer.
Features of the Copy Number Variation of Certain Genes in Tumor Cells in Patients with Serous Ovarian Adenocarcinoma.
Fish oil administration mediates apoptosis of Walker 256 tumor cells by modulation of p53, Bcl-2, caspase-7 and caspase-3 protein expression.
Functional characterization of hepatoma-specific stem cell antigen-2.
Gedunin Inactivates the Co-chaperone p23 Protein Causing Cancer Cell Death by Apoptosis.
Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17.
Germacrone Inhibits Cell Proliferation and Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cells.
Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy.
Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors.
Heat shock protein 70-2 (HSP70-2) a novel cancer testis antigen that promotes growth of ovarian cancer.
HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk.
ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis.
Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening.
Immunoreactivity to caspase-3, caspase-7, caspase-8, and caspase-9 forms is frequently lost in human prostate tumors.
Implication of calpain in caspase activation during B cell clonal deletion.
Improving Topical Non-Melanoma Skin Cancer Treatment: In vitro Efficacy of a Novel Guanosine-Analog Phosphonate.
Inactivated Sendai Virus Strain Tianjin Induces Apoptosis in Breast Cancer MCF-7 Cells by Promoting Caspase Activation and Fas/FasL Expression.
Inactivating mutations of CASPASE-7 gene in human cancers.
Influence of Canine Macrophage-derived Extracellular Vesicles on Apoptosis in Canine Melanoma and Osteosarcoma Cell Lines.
Inhibitory role of peroxisome proliferator-activated receptor gamma in hepatocarcinogenesis in mice and in vitro.
Integrative in silico and in vitro transcriptomics analysis revealed new lncRNAs related to intrinsic apoptotic genes in colorectal cancer.
Investigating cytokinesis failure as a strategy in cancer therapy.
Ketoconazole Treatment Decreases the Viability of Immortalized Pituitary Cell Lines Associated with an Increased Expression of Apoptosis-Related Genes and Cell Cycle Inhibitors.
Large-scale expression in Escherichia coli and efficient purification of precursor and active caspase-7 by introduction of thrombin cleavage sites.
Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers.
MicroRNA-106b-25 cluster expression is associated with early disease recurrence and targets caspase-7 and focal adhesion in human prostate cancer.
MicroRNA-23a is involved in tumor necrosis factor-? induced apoptosis in mesenchymal stem cells and myocardial infarction.
MicroRNA-519a-3p mediates apoptosis resistance in breast cancer cells and their escape from recognition by natural killer cells.
miR-224 Is Significantly Upregulated and Targets Caspase-3 and Caspase-7 During Colorectal Carcinogenesis.
Modulation of effector caspase cleavage determines response of breast and lung tumor cell lines to chemotherapy.
Nitrogen Permease Regulator-Like-2 Exhibited Anti-Tumor Effects And Enhanced The Sensitivity Of Colorectal Cancer Cells To Oxaliplatin And 5-Fluorouracil.
Overexpression of caspase 7 is ER? dependent to affect proliferation and cell growth in breast cancer cells by targeting p21(Cip).
Plasminogen kringle 5 suppresses gastric cancer via regulating HIF-1? and GRP78.
Pogostone Induces Autophagy and Apoptosis Involving PI3K/Akt/mTOR Axis in Human Colorectal Carcinoma HCT116 cells.
Polymorphisms and haplotypes in the caspase-3, caspase-7, and caspase-8 genes and risk for endometrial cancer: a population-based, case-control study in a Chinese population.
Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis.
Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays.
Potentially Functional Polymorphisms in the CASP7 Gene Contribute to Gastric Adenocarcinoma Susceptibility in an Eastern Chinese Population.
Selenopheno quinolinones and coumarins promote cancer cell apoptosis by ROS depletion and caspase-7 activation.
Sequence and expression variations in 23 genes involved in mitochondrial and non-mitochondrial apoptotic pathways and risk of oral leukoplakia and cancer.
Stable silencing of ROR1 regulates cell cycle, apoptosis, and autophagy in a lung adenocarcinoma cell line.
Suppression of tumor cell proliferation and migration by human umbilical cord mesenchymal stem cells: A possible role for apoptosis and Wnt signaling.
Synergistic effects of 7-O-geranylquercetin and siRNAs on the treatment of human breast cancer.
Synthesis of D-ring annulated pyridosteroids from ?-formyl enamides and their biological evaluations.
Synthesis, Characterization, and In Vivo Anti-Cancer Activity of New Metal Complexes Derived from Isatin-N(4)antipyrinethiosemicarbazone Ligand Against Ehrlich Ascites Carcinoma Cells.
Targeted apoptotic effects of thymoquinone and tamoxifen on XIAP mediated Akt regulation in breast cancer.
Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies.
The Caspase-3/PKC?/Akt/VEGF-A Signaling Pathway Mediates Tumor Repopulation during Radiotherapy.
The combination effects of Shen-Ling-Bai-Zhu on promoting apoptosis of transplanted H22 hepatocellular carcinoma in mice receiving chemotherapy.
The novel camptothecin derivative, CPT211, induces cell cycle arrest and apoptosis in models of human breast cancer.
Therapeutic targeting of Id2 reduces growth of human colorectal carcinoma in the murine liver.
Transduction motif analysis of gastric cancer based on a human signaling network.
Trifluridine selectively inhibits cell growth and induces cell apoptosis of triple-negative breast cancer.
Unshackling caspase-7 for cancer therapy.
[Expression of survivin and its correlation to angiogenesis in oral squamous cell carcinoma]
[Investigation of the mechanisms of coagulation factor VIIa-induced colon cancer SW620 cell proliferation and migration]
[Study on Apoptosis of Oral Squamous Carcinoma Cell line KB and KBv200 induced by Survivin RNAi.]
Neoplasms, Germ Cell and Embryonal
Failure of activation of caspase-9 induces a higher threshold for apoptosis and cisplatin resistance in testicular cancer.
Neuroblastoma
Identification of genes associated with paraquat-induced toxicity in SH-SY5Y cells by PCR array focused on apoptotic pathways.
Synergistic induction of apoptosis in neuroblastoma cells using a combination of cytostatic drugs with interferon-gamma and TRAIL.
Neurodegenerative Diseases
Calpain-1 cleaves and activates caspase-7.
Caspase-7: a critical mediator of optic nerve injury-induced retinal ganglion cell death.
Cerebellar allografts survive and transiently alleviate ataxia in a transgenic model of spinocerebellar ataxia type-1.
Non-alcoholic Fatty Liver Disease
Adipose tissue remodelling in obese subjects is a determinant of presence and severity of fatty liver disease.
Olivopontocerebellar Atrophies
The hereditary ataxias.
Osteosarcoma
Interferon-? Sensitises Human Osteosarcoma Cells to Trail-mediated Apoptosis.
Serine/Threonine Kinase 35, a Target Gene of STAT3, Regulates the Proliferation and Apoptosis of Osteosarcoma Cells.
Targeted inhibition of mTORC2 prevents osteosarcoma cell migration and promotes apoptosis.
Ovarian Neoplasms
HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells.
Pancreatitis
Genetic Susceptibility in Acute Pancreatitis: Genotyping of GSTM1, GSTT1, GSTP1, CASP7, CASP8, CASP9, CASP10, LTA, TNFRSF1B, and TP53 Gene Variants.
Parkinson Disease
Analysis of SCA-2 and SCA-3 repeats in Parkinsonism: evidence of SCA-2 expansion in a family with autosomal dominant Parkinson's disease.
Mutation at the SCA17 locus is not a common cause of parkinsonism.
Parkinsonian Disorders
Analysis of SCA-2 and SCA-3 repeats in Parkinsonism: evidence of SCA-2 expansion in a family with autosomal dominant Parkinson's disease.
Mutation at the SCA17 locus is not a common cause of parkinsonism.
SCA-2 presenting as parkinsonism in an Alberta family: clinical, genetic, and PET findings.
Periodontitis
Caspase activation is involved in chronic periodontitis.
Prostatic Neoplasms
Apoptotic activity and mechanism of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic-acid and related synthetic triterpenoids in prostate cancer.
Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP.
Endoplasmic reticulum stress signal mediators are targets of selenium action.
MicroRNA-106b-25 cluster expression is associated with early disease recurrence and targets caspase-7 and focal adhesion in human prostate cancer.
Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy.
Signaling pathway activated during apoptosis of the prostate cancer cell line LNCaP: overexpression of caspase-7 as a new gene therapy strategy for prostate cancer.
Pulmonary Disease, Chronic Obstructive
Elevated serum matrix metalloprotease (MMP-2) as a candidate biomarker for stable COPD.
Rectal Neoplasms
[Genetic variations in apoptosis genes are associated with acute adverse events in postoperative rectal cancer patients receiving concurrent chemoradiotherapy].
Reflex, Abnormal
Late-onset SCA2: 33 CAG repeats are sufficient to cause disease.
Retinal Degeneration
Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degeneration.
Modulation of the Rate of Retinal Degeneration in T17M RHO Mice by Reprogramming the Unfolded Protein Response.
Salmonella Infections
Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes.
Sarcoma, Ewing
IFN-beta induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7.
Seizures
Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures.
Sepsis
NLRP3 Inflammasome Deficiency Protects Against Microbial Sepsis via Increased Lipoxin B4 Synthesis.
Skin Neoplasms
Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17.
Spastic Paraplegia, Hereditary
Spastic paraplegia, ataxia, mental retardation (SPAR): a novel genetic disorder.
Spinocerebellar Ataxias
An interrupted 34-CAG repeat SCA-2 allele in patients with sporadic spinocerebellar ataxia.
Cerebellar allografts survive and transiently alleviate ataxia in a transgenic model of spinocerebellar ataxia type-1.
Confirmation of the SCA-2 locus as an alternative locus for dominantly inherited spinocerebellar ataxias and refinement of the candidate region.
Damage to the reticulotegmental nucleus of the pons in spinocerebellar ataxia type 1, 2, and 3.
Genetic analysis of ten common degenerative hereditary ataxia loci in patients with essential tremor.
Structural and immunocytochemical features of olivopontocerebellar atrophy caused by the spinocerebellar ataxia type 1 (SCA-1) mutation define a unique phenotype.
Synapses in the hereditary ataxias.
Transglutaminase-dependent formation of protein aggregates as possible biochemical mechanism for polyglutamine diseases.
Starvation
Canavanine augments proapoptotic effects of arginine deprivation in cultured human cancer cells.
Stomach Neoplasms
Potentially Functional Polymorphisms in the CASP7 Gene Contribute to Gastric Adenocarcinoma Susceptibility in an Eastern Chinese Population.
Prognostic significance of mRNA expression of CASPs in gastric cancer.
Sine Oculis Homeobox Homolog 1 Regulates Mitochondrial Apoptosis Pathway Via Caspase-7 In Gastric Cancer Cells.
Uterine Cervical Neoplasms
CASP7 variants modify susceptibility to cervical cancer in Chinese women.
Vesicular Stomatitis
Requirement of caspase-3 for efficient apoptosis induction and caspase-7 activation but not viral replication or cell rounding in cells infected with vesicular stomatitis virus.