3.4.22.60: caspase-7
This is an abbreviated version!
For detailed information about caspase-7, go to the full flat file.
Word Map on EC 3.4.22.60
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3.4.22.60
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caspase-3
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bcl-2
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parp
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anti-apoptotic
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pro-apoptotic
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executioner
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necrosis
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polyadp-ribose
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caspase-dependent
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annexin
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tunel
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survivin
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cyclin
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apoptosis-inducing
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adp-ribose
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apoptosis-related
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bid
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xiap
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calpains
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pan-caspase
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jnk
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cdk2
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hoechst
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caspase-mediated
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antiproliferative
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apaf-1
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z-vad-fmk
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caspase-3-like
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pyroptosis
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ac-devd-cho
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apoptosome
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template-based
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puma
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trail-induced
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devd
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caspase-3-deficient
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mitochondria-dependent
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procaspase
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apoptosis-associated
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molecular biology
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casp10
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spinocerebellar
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sub-g1
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medicine
- 3.4.22.60
- caspase-3
- bcl-2
- parp
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anti-apoptotic
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pro-apoptotic
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executioner
- necrosis
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polyadp-ribose
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caspase-dependent
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annexin
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tunel
- survivin
- cyclin
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apoptosis-inducing
- adp-ribose
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apoptosis-related
- bid
- xiap
- calpains
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pan-caspase
- jnk
- cdk2
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hoechst
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caspase-mediated
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antiproliferative
- apaf-1
- z-vad-fmk
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caspase-3-like
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pyroptosis
- ac-devd-cho
- apoptosome
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template-based
- puma
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trail-induced
- devd
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caspase-3-deficient
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mitochondria-dependent
-
procaspase
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apoptosis-associated
- molecular biology
- casp10
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spinocerebellar
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sub-g1
- medicine
Reaction
strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-/- =
Synonyms
apoptotic protease Mch-3, C14.004, Casp-7, Casp7, caspase 7, caspase-7, CMH-1, cystein aspartic-specific protease-7, DEVDase, ICE-LAP3, ICE-like apoptotic protease 3, LICE2 cysteine protease, More, SCA-2, SREBP cleavage activity 2
ECTree
3.4.22.60 caspase-7Advanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 3.4.22.60 - caspase-7
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
26S proteasome subunit + H2O
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during apoptosis, the activated caspase-7 directly cleaves certain subunits of 26S proteasomes, which then result in a decline in the proteasomal activity
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?
acid sphingomyelinase + H2O
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caspase-7 activates acid sphingomyelinase induced by TNF, overview. Generation of the active 57 kDa fragment of endogenous A-SMase in wild-type HeLa cells. Direct association of caspase-7 and A-SMase within TNF receptosomes
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ataxin-7 + H2O
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ataxin-7 is cleaved by caspase-7, cleavage sites to Asp residues at positions 266 and 344 of the ataxin-7 protein. Proteolytic processing of ataxin-7 by caspase-7 may contribute to SCA7 disease pathogenesis
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caspase-7 biosensor vDEVDc + H2O
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wild-type caspase-7 binds to caspase-7 biosensor vDEVDc, but does not cleave it, while an mutant isozymes of caspase-7 with the 24 or 56 N-terminal residues truncated, i.e. 24casp7 and 57casp7, respectively, cleave vDEVDc at the recognition sequence
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?
Kaposi sarcoma-associated herpesvirus ORF57 + H2O
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a viral early protein essential for KSHV multiplication. Cleavage of wild-type or mutant D33A ORF57 by valproate-induced BCBL-1 cell extracts containing active caspases
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?
kinectin + H2O
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kinectin is cleaved by caspase 7 during apoptosis induced by different stimuli. Kinectin functions as a membrane anchor for kinesin and may be relevant to the disruption of vesicle trafficking during apoptosis
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?
mammalian sterile 20-like kinase 1 + H2O
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i.e. Mst1. Caspase 7 preferentially activates c-Jun NH2-terminal kinase and p38 preferentially through 40000 Da cleaved forms of Mst1. The 40000 Da form of Mst1 selectively phosphorylates c-Jun NH2-terminal kinase and p38
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?
p23 + H2O
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better substrate for caspase-7 than caspase-3. p23 is cleaved at site PEVD*G
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?
poly(ADP ribose) polymerase 1 + H2O
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better substrate for caspase-7 than caspase-3, PARP-1 is cleaved at the canonical caspase-3/7 site DEVD*G
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?
poly-ADPribose polymerase 1 + H2O
poly-ADPribose polymerase 1 peptide fragments
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i.e. c-PARP, frgaments of 24 and 89 kDa
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?
pro-endothelial monocyte-activating polypeptide II + H2O
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caspase-7-mediated generation and release of mature endothelial monocyte-activating polypeptide II may provide a mechanism for leukocyte recruitment to sites of programmed cell death, and thus may link apoptosis to inflammation
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?
valosin-containing protein + H2O
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cleavage by caspase-7 during apoptosis
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?
viral nucleocapsid protein of transmissible gastroenteritis coronovirus + H2O
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cleavage site VVPD359-/-. Destruction of viral protein by the host cell death machinery
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?
poly(ADP-ribose) polymerase + H2O
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whereas caspase-7 can cleave poly(ADP-ribose) polymerase in vivo, a collaborating caspase facilitates access to poly(ADP-ribose) polymerase, possibly by enhancing nuclear entry
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?
poly(ADP-ribose) polymerase + H2O
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the cleavage of poly(ADP-ribose) polymerase observed during apoptosis cannot solely be attributed to CPP32 but can also be an activity of Mch2alpha
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?
additional information
?
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apoptosis is a result of a complex network of signaling pathways initiating from both inside and outside the cell, culminating in the activation of caspases, cyteine aspartate proteases, that execute the final stages of cell death
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?
additional information
?
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caspase-7 is the most downstream caspase, overexpression does not lead to the activation of other caspases
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?
additional information
?
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the enzyme is activated during Fas- and tumor necrosis factor-induced apoptosis
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?
additional information
?
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the enzyme is activated during Fas- and tumor necrosis factor-induced apoptosis
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?
additional information
?
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caspase-7 is an executioner protease in cellular apoptosis
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additional information
?
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caspase-7 is an important executioner caspase capable of conducting most of apoptotic program in cells
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?
additional information
?
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caspase-7 is involved in apoptosis and glioblastoma, regulation, overview
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?
additional information
?
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caspase-7 is involved in apoptosis in cancer cells
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?
additional information
?
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caspase-7 is involved in apoptosis. Follistatin-like 1, FSTL1, induces apoptosis in cancer cells and leads to activation of caspase-7 when transfected to ovarian or endometrial cancer or healthy cells, regulation, overview
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?
additional information
?
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functions of caspase-7 during apoptosis, overview
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additional information
?
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hypertonicity-induced cation channels, HICC, inhibition by flufenamate and silencing of alpha-ENaC increases the rate of apoptosis in HepG2 cells via activation of caspase-7 or caspase-3
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additional information
?
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inhibition of executioner caspase enzymatic activity by TLCK and TPCK in dying HL-60 cells is important in prevention of cell death
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additional information
?
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members of the caspase family of cysteine proteases play central roles in coordinating the stereotypical events that occur during apoptosis, the major executioner caspases are caspase-3 and caspase-7, which show overlapping substrate specificities, overview
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?
additional information
?
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possible involvement of caspase-7 in cell cycle progression at mitosis, caspases including caspase-3, caspase-7, caspase-8 and caspase-9, are activated during mitosis and are potentially involved in the regulation at M phase. Chemically synthesized caspase inhibitors delay mitotic progression and induce accumulation of mitotic cells, which exhibits abnormal chromatin condensation and incomplete chromosome segregation
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additional information
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tyrosine kinase TrkA overexpression induces substantial cell death even in the absence of NGF, by stimulating ERK phosphorylation and caspase-7 activation leading to PARP cleavage, mechanism, overview
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additional information
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intracellular pathogen Legionella pneumophila strain Lp02 infection of murine macrophages leads to caspase-7 activation downstream of the Nlrc4 inflammasome requiring activation by caspase-1, overview. Caspase-1-dependent caspase-7 activation contributes to Legionella pneumophila phagosome maturation in macrophages
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?
additional information
?
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members of the caspase family of cysteine proteases play central roles in coordinating the stereotypical events that occur during apoptosis, the major executioner caspases are caspase-3 and caspase-7, which show overlapping substrate specificities, overview
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?
additional information
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the apoptotic executioner caspase-7 is activated in the splenocytes of lipopolysaccharide-injected mice, suggesting a role for caspase-7 in lymphocyte apoptosis. Caspase-7 deficiency and caspase inhibition protect from endotoxin-induced lymphocyte apoptosis and improve survival
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additional information
?
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intracellular pathogen Legionella pneumophila strain Lp02 infection of murine macrophages leads to caspase-7 activation downstream of the Nlrc4 inflammasome requiring activation by caspase-1, overview. Caspase-1-dependent caspase-7 activation contributes to Legionella pneumophila phagosome maturation in macrophages
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?
