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Literature summary for 3.4.22.60 extracted from

  • Pai J.T.; Brown M.S.; Goldstein J.L.
    Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins (1996), Proc. Natl. Acad. Sci. USA, 93, 5437-5442.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.60

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mesocricetus auratus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mesocricetus auratus 5829
-
plasma membrane juxtamembrane structures Mesocricetus auratus 5886
-

Organism

Organism UniProt Comment Textmining
Mesocricetus auratus P55214
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification enzyme is synthesized as an inactive 30000-35000 Da precursor and is thought to be cleaved during apoptosis to generate active fragments of 20000 Da and 10000 Da Mesocricetus auratus

Purification (Commentary)

Purification (Comment) Organism
-
 Mesocricetus auratus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mesocricetus auratus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
poly(ADP-ribose) polymerase + H2O
-
 Mesocricetus auratus ?
-
 ?
sterol regulatory element binding protein-2 + H2O SREBP-2 is sterol regulatory element binding protein-2 Mesocricetus auratus ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
 cleavage of sterol regulatory element binding protein Mesocricetus auratus

pH Range

pH Minimum pH Maximum Comment Organism
6 7 pH 6.0: about 35% of maximal activity, pH 7.0: about 15% of maximal activity, cleavage of sterol regulatory element binding protein Mesocricetus auratus