Cloned (Comment) | Organism |
---|---|
bacterially expressed Mch3 has intrinsic autocatalytic and autoactivation activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cowpox seroin CrmA | very weak inhibitor | Homo sapiens | |
DEVD-aldehyde | potent inhibitor | Homo sapiens | |
YVAD-aldehyde | weak inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
poly(ADP-ribose) polymerase + H2O | Homo sapiens | the cleavage of poly(ADP-ribose) polymerase observed during apoptosis cannot solely be attributed to CPP32 but can also be an activity of Mch2alpha | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P55210 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | Mch3alpha is made of two subunits derived from a precursor ProMch3alpha. Asp23 and Asp198 are the most likely processing sites. Bacterially expressed Mch3 has intrinsic autocatalytic and autoactivation activity | Homo sapiens |
proteolytic modification | CPP32 can efficiently cleave proMch3alpha | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
T-cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DEVD-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | DEVD + 7-amino-4-methylcoumarin | - |
? | |
additional information | no cleavage of YVAD-7-amido-4-methylcoumarin | Homo sapiens | ? | - |
? | |
poly(ADP-ribose) polymerase + H2O | - |
Homo sapiens | ? | - |
? | |
poly(ADP-ribose) polymerase + H2O | the cleavage of poly(ADP-ribose) polymerase observed during apoptosis cannot solely be attributed to CPP32 but can also be an activity of Mch2alpha | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | it is proposed that the 22000 Da peptide and the 12000 Da peptide are two subunits of the enzyme | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000018 | - |
DEVD-aldehyde | pH 7.5, 37°C | Homo sapiens |