3.4.22.60: caspase-7

This is an abbreviated version!
For detailed information about caspase-7, go to the full flat file.

Word Map on EC 3.4.22.60

3.4.22.60

caspase-3

bcl-2

parp

anti-apoptotic

pro-apoptotic

executioner

necrosis

polyadp-ribose

caspase-dependent

annexin

tunel

survivin

cyclin

apoptosis-inducing

adp-ribose

apoptosis-related

bid

xiap

calpains

pan-caspase

jnk

cdk2

hoechst

caspase-mediated

antiproliferative

apaf-1

z-vad-fmk

caspase-3-like

pyroptosis

ac-devd-cho

apoptosome

template-based

puma

trail-induced

devd

caspase-3-deficient

mitochondria-dependent

procaspase

apoptosis-associated

molecular biology

casp10

spinocerebellar

sub-g1

medicine

Reaction

strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-/- =

Synonyms

apoptotic protease Mch-3, C14.004, Casp-7, Casp7, caspase 7, caspase-7, CMH-1, cystein aspartic-specific protease-7, DEVDase, ICE-LAP3, ICE-like apoptotic protease 3, LICE2 cysteine protease, More, SCA-2, SREBP cleavage activity 2

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.60 caspase-7

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
27	Activating Compound
57	AA Sequence
14	Application
1	CAS Registry Number
28	Cloned(Commentary)
4	Crystallization (Commentary)
827	Disease/ Diagnostics
1	Expression
15	General Information
29	IC50 Value
79	Inhibitors
17	kcat/KM [mM/s]
11	Ki Value [mM]
35	KM Value [mM]
17	Localization
8	Molecular Weight [Da]
54	Natural Substrates/ Products (Substrates)
223	Organism
117	PDB ID
8	pH Optimum
1	pH Range
16	Posttranslational Modification
31	Protein Variants
14	Purification (Commentary)
2	Reaction
1	Reaction Type
84	Reference
123	Source Tissue
1	Specific Activity [micromol/min/mg]
141	Substrates and Products (Substrate)
8	Subunits
24	Synonyms
4	Temperature Optimum [°C]
27	Turnover Number [1/s]

IC50 Value

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

IC50 Value on EC 3.4.22.60 - caspase-7

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to IC50 Value Search

0.000111

(S)-1-(11,11-difluoroundecyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Homo sapiens

696749

0.000266

(S)-1-(2-fluoroallyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Homo sapiens

696749

0.00294

(S)-1-(2-fluoroethyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Homo sapiens

696749

0.000123

(S)-1-(3-chloro-2-hydroxypropyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Homo sapiens

696749

0.000079

(S)-1-(3-chloropropyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Homo sapiens

696749

0.0000068

(S)-1-(3-fluorobutyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Homo sapiens

696749

0.00144

(S)-1-(3-fluoropropyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Homo sapiens

696749

0.000052

(S)-1-(3-hydroxypropyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Homo sapiens

696749

0.000028

(S)-1-(4-fluorobutyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Homo sapiens

696749

0.000011

(S)-1-(4-hydroxybutyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Homo sapiens

696749

0.0000081

(S)-1-butyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Homo sapiens

696749

0.000319

(S)-1-ethyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Homo sapiens

696749

0.113

(S)-1-[3-(3-hydroxypropoxy)propyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Homo sapiens

696749

0.0194

(S)-1-[3-[3-(2-fluoroethoxy)propoxy]propyl]-5-[1-(2-methoxymethylpyrrolidinyl)-sulfonyl]isatin

Homo sapiens

696749

0.00564

(S)-3,3-difluoro-1-(3-fluoropropyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]indolin-2-one

Homo sapiens

696749

0.000135

(S)-3,5-bis-trifluoromethylbenzyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Homo sapiens

696749

0.000129

(S)-3-[5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-2,3-dioxoindolin-1-yl]propanoic acid

Homo sapiens

696749

0.000217

(S)-3-[5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-2,3-dioxoindolin-1-yl]propyl methanesulfonate

Homo sapiens

696749

0.000044

(S)-4-fluorobenzyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Homo sapiens

696749

0.000011

(S)-4-trifluoromethylbenzyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Homo sapiens

696749

0.000029

(S)-4-[5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-2,3-dioxoindolin-1-yl]butyl 4-methyl-benzenesulfonate

Homo sapiens

696749

0.00004

(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-(3,3,3-trifluoropropyl)isatin

Homo sapiens

696749

0.000178

(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-(3,4,4-trifluorobut-3-enyl)isatin

Homo sapiens

696749

0.0001

(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-(4,4,4-trifluorobutyl)isatin

Homo sapiens

696749

0.000304

(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-methylisatin

Homo sapiens

696749

0.000058

(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-propylisatin

Homo sapiens

696749

3.98

2-[(2-acetylphenyl)sulfanyl]benzoic acid

Homo sapiens

P55210

pH not specified in the publication, temperature not specified in the publication

752489

0.00017

5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Homo sapiens

696749

0.637

[2-(phenylsulfanyl)phenyl]acetic acid

Homo sapiens

P55210

pH not specified in the publication, temperature not specified in the publication

752489