Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activation of caspase-7 in macrophages by cleavage through caspase-1 is mediated by bacterial flagellin and absolutely requires a functional host proteins Nlrc4 and Naip5 | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expression of caspase-7 in caspase-7-deficient mouse macrophages | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mice lacking caspase-7 and its macrophages allow substantial Legionella pneumophila replication, while wild-type mouse strains are restrictive to Legionella pneumophila infection | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | intracellular pathogen Legionella pneumophila strain Lp02 infection of murine macrophages leads to caspase-7 activation downstream of the Nlrc4 inflammasome requiring activation by caspase-1, overview. Caspase-1-dependent caspase-7 activation contributes to Legionella pneumophila phagosome maturation in macrophages | ? | - |
? | |
additional information | Mus musculus C57BL/6 | intracellular pathogen Legionella pneumophila strain Lp02 infection of murine macrophages leads to caspase-7 activation downstream of the Nlrc4 inflammasome requiring activation by caspase-1, overview. Caspase-1-dependent caspase-7 activation contributes to Legionella pneumophila phagosome maturation in macrophages | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6 mice | - |
Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | procaspase-7 is activated by caspase-1 cleavage to caspase-7 | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | bone marrow macrophages prepared from femurs of five to eight-week-old mice | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | intracellular pathogen Legionella pneumophila strain Lp02 infection of murine macrophages leads to caspase-7 activation downstream of the Nlrc4 inflammasome requiring activation by caspase-1, overview. Caspase-1-dependent caspase-7 activation contributes to Legionella pneumophila phagosome maturation in macrophages | Mus musculus | ? | - |
? | |
additional information | intracellular pathogen Legionella pneumophila strain Lp02 infection of murine macrophages leads to caspase-7 activation downstream of the Nlrc4 inflammasome requiring activation by caspase-1, overview. Caspase-1-dependent caspase-7 activation contributes to Legionella pneumophila phagosome maturation in macrophages | Mus musculus C57BL/6 | ? | - |
? |