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Literature summary for 3.4.22.60 extracted from

  • Clarke, C.A; Bennett, L.N.; Clarke, P.R.
    Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway (2005), J. Biol. Chem., 280, 35337-35345.
    View publication on PubMed
Search for more literature for 3.4.22.60

Activating Compound

Activating Compound Comment Organism Structure
etoposide
-
 Homo sapiens

Application

Application Comment Organism
medicine cleavage of claspin by caspase-7 inactivates the Chk1 signaling pathway, this mechanism may regulate the balance between cell cycle arrest and induction of apoptosis during response of genotoxic stress Homo sapiens
medicine cleavage of claspin by caspase-7 inactivates the Chk1 signaling pathway, this mechanism may regulate the balance between cell cycle arrest and induction of apoptosis during response of genotoxic stress Xenopus laevis

Inhibitors

Inhibitors Comment Organism Structure
Ac-DEVD-CHO
-
 Homo sapiens
Ac-DEVD-CHO
-
 Xenopus laevis
Z-Val-Ala-Asp-fluoromethylketone
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
nucleus
-
 Homo sapiens 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
250000
-
 Western blot analysis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Xenopus laevis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
egg
-
 Xenopus laevis
-
HeLa cell
-
 Homo sapiens
-
JURKAT cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ac-DEVD-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Ac-DEVD + 7-amino-4-methylcoumarin
-
 ?
claspin + H2O cleaved by caspase-7 during the initiation of apoptosis, cleavage at a single aspartate residue into a large N-terminal fragment and a smaller C-terminal fragment that contain different functional domains Homo sapiens ?
-
 ?
claspin + H2O cleaved by caspase-7 during the initiation of apoptosis, cleavage at a single aspartate residue into a large N-terminal fragment and a smaller C-terminal fragment that contain different functional domains Xenopus laevis ?
-
 ?
PARP + H2O cleaved by caspase-7 during the initiation of apoptosis, cleavage at a single aspartate residue into a large N-terminal fragment and a smaller C-terminal fragment that contains different functional domains Homo sapiens ?
-
 ?