3.4.22.60: caspase-7
This is an abbreviated version!
For detailed information about caspase-7, go to the full flat file.
Word Map on EC 3.4.22.60
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3.4.22.60
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caspase-3
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bcl-2
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parp
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anti-apoptotic
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pro-apoptotic
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executioner
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necrosis
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polyadp-ribose
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caspase-dependent
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annexin
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tunel
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survivin
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cyclin
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apoptosis-inducing
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adp-ribose
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apoptosis-related
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bid
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xiap
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calpains
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pan-caspase
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jnk
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cdk2
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hoechst
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caspase-mediated
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antiproliferative
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apaf-1
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z-vad-fmk
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caspase-3-like
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pyroptosis
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ac-devd-cho
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apoptosome
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template-based
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puma
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trail-induced
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devd
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caspase-3-deficient
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mitochondria-dependent
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procaspase
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apoptosis-associated
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molecular biology
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casp10
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spinocerebellar
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sub-g1
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medicine
- 3.4.22.60
- caspase-3
- bcl-2
- parp
-
anti-apoptotic
-
pro-apoptotic
-
executioner
- necrosis
-
polyadp-ribose
-
caspase-dependent
-
annexin
-
tunel
- survivin
- cyclin
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apoptosis-inducing
- adp-ribose
-
apoptosis-related
- bid
- xiap
- calpains
-
pan-caspase
- jnk
- cdk2
-
hoechst
-
caspase-mediated
-
antiproliferative
- apaf-1
- z-vad-fmk
-
caspase-3-like
-
pyroptosis
- ac-devd-cho
- apoptosome
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template-based
- puma
-
trail-induced
- devd
-
caspase-3-deficient
-
mitochondria-dependent
-
procaspase
-
apoptosis-associated
- molecular biology
- casp10
-
spinocerebellar
-
sub-g1
- medicine
Reaction
strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-/- =
Synonyms
apoptotic protease Mch-3, C14.004, Casp-7, Casp7, caspase 7, caspase-7, CMH-1, cystein aspartic-specific protease-7, DEVDase, ICE-LAP3, ICE-like apoptotic protease 3, LICE2 cysteine protease, More, SCA-2, SREBP cleavage activity 2
ECTree
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Application
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medicine
molecular biology
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engineering of CHO cells for more robust cell lines includes reduction of apoptotic capase-7, overview
additional information
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apoptosis is preceded by proteolytic cleavage of e.g. caspase 7, prolonged nuclear localization of activated signal transducer and activator of transcription 1 results in apoptosis involving specific regulation of caspase pathway
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Actinobacillus actinomycetemcomitans cytolethal distending toxin acts as an immunosuppressive factor, it possesses the ability to induce human T-cell apoptosis through activation of caspase-7
medicine
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acute hemorrhagic conjunctivitis, Enterovirus 70 infection induces caspase-7-mediated apoptosis
medicine
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cleavage of claspin by caspase-7 inactivates the Chk1 signaling pathway, this mechanism may regulate the balance between cell cycle arrest and induction of apoptosis during response of genotoxic stress
medicine
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cleavage of claspin by caspase-7 inactivates the Chk1 signaling pathway, this mechanism may regulate the balance between cell cycle arrest and induction of apoptosis during response of genotoxic stress
medicine
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hydrophobic P5 residue has a favorable contribution to the recognition and hydrolysis of substrates but not by caspase-7, this information helps to design specific inhibitors for each caspase
medicine
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low-dosage topoisomerase II inhibitor etoposide effectively inhibits proliferation rate
medicine
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strong correlation between caspase-7 activity, normal brain development, and apoptotic DNA fragmenation in Casp3-/-mice
medicine
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strong correlation between caspase-7 activity, normal brain development, and apoptotic DNA fragmenation in Casp3-/-mice, caspase-7 is a caspase-3 surrogate in Casp3-/-mice
medicine
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substitution in the P1' position could be used in synergy with other elements to obtain highly potent and isozyme-selective caspase inhibitors
medicine
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SUMO-1 modification in caspase-7 may contribute to the cleavage of nuclear substrates during neuronal apoptosis
medicine
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caspase-7 may play a role in ataxin-7 proteolysis and pathology of spinocerebellar ataxia type 7. Inhibition of this protease may be therapeutically important
medicine
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involvement of the CASP7 gene in the susceptibility to rheumatoid arthritis. The higher production of the no functional variant of CASP7 by individuals with a particular genotype could be the basis of this association