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Literature summary for 3.4.22.60 extracted from

  • Mills, E.; Chen, X.; Pham, E.; Wong, S.; Truong, K.
    Engineering a photoactivated caspase-7 for rapid induction of apoptosis (2012), ACS Synth. Biol., 1, 75-82.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS7 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Z-DEVD-fluoromethylketone
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pLyn-yellow-fluorescent protein-DEVD-DEVD-C fluorescent protein + H2O
-
Homo sapiens pLyn-yellow-fluorescent protein-DEVD + DEVD-cyan fluorescent protein
-
?

General Information

General Information Comment Organism
physiological function caspase-7 activation is sufficient to start apoptosis, but it requires mitochondrial contribution to fully commit Homo sapiens