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3.4.22.60: caspase-7

This is an abbreviated version!
For detailed information about caspase-7, go to the full flat file.

Word Map on EC 3.4.22.60

Reaction

strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-/- =

Synonyms

apoptotic protease Mch-3, C14.004, Casp-7, Casp7, caspase 7, caspase-7, CMH-1, cystein aspartic-specific protease-7, DEVDase, ICE-LAP3, ICE-like apoptotic protease 3, LICE2 cysteine protease, More, SCA-2, SREBP cleavage activity 2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.60 caspase-7

Inhibitors

Inhibitors on EC 3.4.22.60 - caspase-7

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(S)-1-(11,11-difluoroundecyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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(S)-1-(2-fluoroallyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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(S)-1-(2-fluoroethyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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(S)-1-(3-chloro-2-hydroxypropyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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(S)-1-(3-chloropropyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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(S)-1-(3-fluorobutyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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(S)-1-(3-fluoropropyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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(S)-1-(3-hydroxypropyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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(S)-1-(4-fluorobutyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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(S)-1-(4-hydroxybutyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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(S)-1-butyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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(S)-1-ethyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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(S)-1-[3-(3-hydroxypropoxy)propyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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(S)-1-[3-[3-(2-fluoroethoxy)propoxy]propyl]-5-[1-(2-methoxymethylpyrrolidinyl)-sulfonyl]isatin
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(S)-3,3-difluoro-1-(3-fluoropropyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]indolin-2-one
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(S)-3,5-bis-trifluoromethylbenzyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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(S)-3-[5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-2,3-dioxoindolin-1-yl]propanoic acid
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(S)-3-[5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-2,3-dioxoindolin-1-yl]propyl methanesulfonate
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(S)-4-fluorobenzyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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(S)-4-trifluoromethylbenzyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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(S)-4-[5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-2,3-dioxoindolin-1-yl]butyl 4-methyl-benzenesulfonate
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(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-(3,3,3-trifluoropropyl)isatin
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(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-(3,4,4-trifluorobut-3-enyl)isatin
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(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-(4,4,4-trifluorobutyl)isatin
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(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-methylisatin
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(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-propylisatin
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2-[(2-acetylphenyl)sulfanyl]benzoic acid
noncompetitive
5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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AC-DEVD-aldehyde inhibitor
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Ac-DEVD-CHO
Ac-DEVD-fluoromethylketone
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a caspase-7 inhibitor
AC-DQTD-CHO
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Ac-Val-Ala-Asp-fluoromethylketone
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acetyl-AEVD-aldehyde
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acetyl-Ala-Pro-Nle-Asp-aldehyde
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acetyl-DEVD-aldehyde
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acetyl-IETD-aldehyde
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Bcl2L12
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is a direct caspase-7-binding and inhibitory protein affecting effector caspase activation, knockdown of Bcl2L12 or to a lesser extent of XIAP and Bcl-2 results in enhanced caspase-7 activation, regulation, overview
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benzyloxycarbonyl-Asp-Glu-Val-Asp-fluoromethyl ketone
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benzyloxycarbonyl-ASTD-fluoromethylketone
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0.01 mM, complete inhibition of cleavage of pro-endothelial monocyte-activating polypeptide II
benzyloxycarbonyl-DEVD-chloromethylketone
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0.01 mM, complete inhibition
benzyloxycarbonyl-Pro-Nle-Asp-aldehyde
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benzyloxycarbonyl-VAD-fluoromethylketone
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t1/2 at 0.001 mM is 98 s
benzyloxycarbonyl-VAD-[(2,6-dichlorobenzoyl)-oxy]methyl ketone
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benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone
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Boc-Asp-fluoromethylketone
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carbobenzyloxy-DEVD-fluoromethyl ketone
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blocks activation of caspase-7
cowpox seroin CrmA
very weak inhibitor
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DEVD-aldehyde
potent inhibitor
DEVD-CHO
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DEVD-fluoromethylketone
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more specific than YVAD-cmk
ketonic peptides
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in the straight-chain aliphatic series, increasing inhibition with increasing chain length, for the unsubstituted aromatic P1' inhibitors increasing potency with decreasing linker length
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N-acetyl-Trp-Glu-His-Asp-CHO
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N-acetyl-Tyr-Val-Ala-Asp-CHO
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N-alpha-tosyl-L-lysyl-chloromethylketone
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i.e. TLCK, substantially inhibits caspase-7 enzymatic DEVDase activity, but does not affect caspase-7 processing in cells exposed to pro-apoptotic inducing stimuli, irreversibly alkylates cysteine residues of the active site of cysteine proteases
N-carbobenzyloxy-VAD-fluoromethyl ketone
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a general caspase inhibitor
N-tosyl-L-phenylalanyl-chloromethylketone
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i.e. TPCK, enhances caspase-7 processing although it substantially inhibits caspase-7 enzymatic DEVDase activity in HL-60 cells exposed to various cell death inducing stimuli, irreversibly alkylates cysteine residues of the active site of cysteine proteases
X-linked inhibitor of apoptosis
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XIAP inhibitors
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peptide inhibitors
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YVAD-aldehyde
weak inhibitor
YVAD-chloromethylketone
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Z-DEVD-fluoromethylketone
Z-VAD-fluoromethylketone
Z-Val-Ala-Asp-fluoromethylketone
[2-(phenylsulfanyl)phenyl]acetic acid
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additional information
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