3.4.22.60: caspase-7
This is an abbreviated version!
For detailed information about caspase-7, go to the full flat file.
Word Map on EC 3.4.22.60
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3.4.22.60
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caspase-3
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bcl-2
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parp
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anti-apoptotic
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pro-apoptotic
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executioner
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necrosis
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polyadp-ribose
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caspase-dependent
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annexin
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tunel
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survivin
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cyclin
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apoptosis-inducing
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adp-ribose
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apoptosis-related
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bid
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xiap
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calpains
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pan-caspase
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jnk
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cdk2
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hoechst
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caspase-mediated
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antiproliferative
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apaf-1
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z-vad-fmk
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caspase-3-like
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pyroptosis
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ac-devd-cho
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apoptosome
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template-based
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puma
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trail-induced
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devd
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caspase-3-deficient
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mitochondria-dependent
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procaspase
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apoptosis-associated
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molecular biology
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casp10
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spinocerebellar
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sub-g1
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medicine
- 3.4.22.60
- caspase-3
- bcl-2
- parp
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anti-apoptotic
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pro-apoptotic
-
executioner
- necrosis
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polyadp-ribose
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caspase-dependent
-
annexin
-
tunel
- survivin
- cyclin
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apoptosis-inducing
- adp-ribose
-
apoptosis-related
- bid
- xiap
- calpains
-
pan-caspase
- jnk
- cdk2
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hoechst
-
caspase-mediated
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antiproliferative
- apaf-1
- z-vad-fmk
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caspase-3-like
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pyroptosis
- ac-devd-cho
- apoptosome
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template-based
- puma
-
trail-induced
- devd
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caspase-3-deficient
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mitochondria-dependent
-
procaspase
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apoptosis-associated
- molecular biology
- casp10
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spinocerebellar
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sub-g1
- medicine
Reaction
strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-/- =
Synonyms
apoptotic protease Mch-3, C14.004, Casp-7, Casp7, caspase 7, caspase-7, CMH-1, cystein aspartic-specific protease-7, DEVDase, ICE-LAP3, ICE-like apoptotic protease 3, LICE2 cysteine protease, More, SCA-2, SREBP cleavage activity 2
ECTree
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Inhibitors
Inhibitors on EC 3.4.22.60 - caspase-7
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(S)-1-(11,11-difluoroundecyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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(S)-1-(3-chloro-2-hydroxypropyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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(S)-1-[3-(3-hydroxypropoxy)propyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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(S)-1-[3-[3-(2-fluoroethoxy)propoxy]propyl]-5-[1-(2-methoxymethylpyrrolidinyl)-sulfonyl]isatin
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(S)-3,3-difluoro-1-(3-fluoropropyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]indolin-2-one
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(S)-3,5-bis-trifluoromethylbenzyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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(S)-3-[5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-2,3-dioxoindolin-1-yl]propanoic acid
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(S)-3-[5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-2,3-dioxoindolin-1-yl]propyl methanesulfonate
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(S)-4-trifluoromethylbenzyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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(S)-4-[5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-2,3-dioxoindolin-1-yl]butyl 4-methyl-benzenesulfonate
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(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-(3,3,3-trifluoropropyl)isatin
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(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-(3,4,4-trifluorobut-3-enyl)isatin
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(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-(4,4,4-trifluorobutyl)isatin
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Bcl2L12
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is a direct caspase-7-binding and inhibitory protein affecting effector caspase activation, knockdown of Bcl2L12 or to a lesser extent of XIAP and Bcl-2 results in enhanced caspase-7 activation, regulation, overview
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benzyloxycarbonyl-ASTD-fluoromethylketone
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0.01 mM, complete inhibition of cleavage of pro-endothelial monocyte-activating polypeptide II
ketonic peptides
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in the straight-chain aliphatic series, increasing inhibition with increasing chain length, for the unsubstituted aromatic P1' inhibitors increasing potency with decreasing linker length
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N-alpha-tosyl-L-lysyl-chloromethylketone
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i.e. TLCK, substantially inhibits caspase-7 enzymatic DEVDase activity, but does not affect caspase-7 processing in cells exposed to pro-apoptotic inducing stimuli, irreversibly alkylates cysteine residues of the active site of cysteine proteases
N-tosyl-L-phenylalanyl-chloromethylketone
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i.e. TPCK, enhances caspase-7 processing although it substantially inhibits caspase-7 enzymatic DEVDase activity in HL-60 cells exposed to various cell death inducing stimuli, irreversibly alkylates cysteine residues of the active site of cysteine proteases
Z-Val-Ala-Asp-fluoromethylketone
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inhibits Enterovirus 70-induced apoptosis and virus release, but not intracellular viral production
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KI-values higher than 0.01 mM are determined for acetyl-WEHD-aldehyde and acetyl-YVAD-aldehyde and cowpox serin CrmA
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additional information
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alphaB-crystallin specifically interacts with and inhibits caspase-3, but not caspase-7
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additional information
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non-selective 1-aminoindan-1,5-dicarboxylic acid and selective (3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl) methanone lead to reduced enzyme expression in in the dorsal horn spinal cord by 3 days post-chronic constrictive injury, overview
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