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Literature summary for 3.4.22.60 extracted from

  • Behrensdorf, H.A.; van de Craen, M.; Knies, U.E.; Vandenabeele, P.; Clauss, M.
    The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7 (2000), FEBS Lett., 466, 143-147.
    View publication on PubMed
Search for more literature for 3.4.22.60

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-ASTD-fluoromethylketone 0.01 mM, complete inhibition of cleavage of pro-endothelial monocyte-activating polypeptide II Mus musculus
benzyloxycarbonyl-DEVD-chloromethylketone 0.01 mM, complete inhibition Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-endothelial monocyte-activating polypeptide II + H2O Mus musculus caspase-7-mediated generation and release of mature endothelial monocyte-activating polypeptide II may provide a mechanism for leukocyte recruitment to sites of programmed cell death, and thus may link apoptosis to inflammation ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-ASTD-7-amido-4-methylcoumarin + H2O
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 Mus musculus acetyl-ASTD + 7-amino-4-methylcoumarin
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 ?
acetyl-DEVD-7-amido-4-methylcoumarin + H2O
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 Mus musculus acetyl-DEVD + 7-amino-4-methylcoumarin
-
 ?
pro-endothelial monocyte-activating polypeptide II + H2O pro-endothelial monocyte-activating polypeptide II in which the ASTD cleavage site is changed to the sequence ASTA, is not processed by caspase-7 Mus musculus endothelial monocyte-activating polypeptide II + ?
-
 ?
pro-endothelial monocyte-activating polypeptide II + H2O caspase-7-mediated generation and release of mature endothelial monocyte-activating polypeptide II may provide a mechanism for leukocyte recruitment to sites of programmed cell death, and thus may link apoptosis to inflammation Mus musculus ?
-
 ?