3.4.22.60: caspase-7
This is an abbreviated version!
For detailed information about caspase-7, go to the full flat file.
Word Map on EC 3.4.22.60
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3.4.22.60
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caspase-3
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bcl-2
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parp
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anti-apoptotic
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pro-apoptotic
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executioner
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necrosis
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polyadp-ribose
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caspase-dependent
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annexin
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tunel
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survivin
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cyclin
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apoptosis-inducing
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adp-ribose
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apoptosis-related
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bid
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xiap
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calpains
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pan-caspase
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jnk
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cdk2
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hoechst
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caspase-mediated
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antiproliferative
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apaf-1
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z-vad-fmk
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caspase-3-like
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pyroptosis
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ac-devd-cho
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apoptosome
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template-based
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puma
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trail-induced
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devd
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caspase-3-deficient
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mitochondria-dependent
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procaspase
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apoptosis-associated
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molecular biology
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casp10
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spinocerebellar
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sub-g1
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medicine
- 3.4.22.60
- caspase-3
- bcl-2
- parp
-
anti-apoptotic
-
pro-apoptotic
-
executioner
- necrosis
-
polyadp-ribose
-
caspase-dependent
-
annexin
-
tunel
- survivin
- cyclin
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apoptosis-inducing
- adp-ribose
-
apoptosis-related
- bid
- xiap
- calpains
-
pan-caspase
- jnk
- cdk2
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hoechst
-
caspase-mediated
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antiproliferative
- apaf-1
- z-vad-fmk
-
caspase-3-like
-
pyroptosis
- ac-devd-cho
- apoptosome
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template-based
- puma
-
trail-induced
- devd
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caspase-3-deficient
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mitochondria-dependent
-
procaspase
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apoptosis-associated
- molecular biology
- casp10
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spinocerebellar
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sub-g1
- medicine
Reaction
strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-/- =
Synonyms
apoptotic protease Mch-3, C14.004, Casp-7, Casp7, caspase 7, caspase-7, CMH-1, cystein aspartic-specific protease-7, DEVDase, ICE-LAP3, ICE-like apoptotic protease 3, LICE2 cysteine protease, More, SCA-2, SREBP cleavage activity 2
ECTree
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Activating Compound
Activating Compound on EC 3.4.22.60 - caspase-7
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2-(4-methoxyphenyl)-4-(piperazin-1-yl)quinoline
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9% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM
2-(4-methoxyphenyl)-N-[2-(morpholin-4-yl)ethyl]quinolin-4-amine
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4% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM
caspase 1
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caspase-7 is cleaved and activated by caspase-1. This is mediated by flagellin and requires the host receptors Nlrc4 and Naip5
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FSH
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antiapoptotic effect on granulosa cells and a proapoptotic effect on theca-interstitial cells
gonadotropins
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increases caspase-7 activity in both theca-interstitial cells and granulosa cells
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LH
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antiapoptotic effect on granulosa cells and a proapoptotic effect on theca-interstitial cells
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N'-[2-(4-ethylphenyl)quinolin-4-yl]-N,N-dimethylethane-1,2-diamine
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17% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM
N'-[2-(4-ethylphenyl)quinolin-4-yl]-N,N-dimethylpropane-1,3-diamine
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26% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM
N'-[2-(4-methoxyphenyl)quinolin-4-yl]-N,N-dimethylethane-1,2-diamine
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123% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM
N'-[2-(4-methoxyphenyl)quinolin-4-yl]-N,N-dimethylpropane-1,3-diamine
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117% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM
N,N-diethyl-N'-[2-(4-ethylphenyl)quinolin-4-yl]propane-1,3-diamine
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24% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM
N,N-diethyl-N'-[2-(4-methoxyphenyl)quinolin-4-yl]propane-1,3-diamine
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124% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM
etoposide
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procaspase-7 cleavage (= activation of caspase-7), which is abrogated in cells with ectopically expressed p53
additional information
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procaspase-7 is physiologically cleaved and activated by caspase-2, optimal conditions, overview
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additional information
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tyrosine kinase TrkA activates caspase-7 in apoptosis
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additional information
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TNF-induced caspase-7 activation takes place exclusively within TNF receptosomes
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additional information
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activation of caspase-7 in macrophages by cleavage through caspase-1 is mediated by bacterial flagellin and absolutely requires a functional host proteins Nlrc4 and Naip5
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additional information
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cordycepin induces caspase-7 protein expression, and apoptosis in MA-10 mouse Leydig tumor cells through a caspase-7 dependent pathway, overview
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additional information
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Escherichia coli lipopolysaccharides induce the enzyme in splenocytes
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