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3.4.22.60: caspase-7

This is an abbreviated version!
For detailed information about caspase-7, go to the full flat file.

Word Map on EC 3.4.22.60

Reaction

strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-/- =

Synonyms

apoptotic protease Mch-3, C14.004, Casp-7, Casp7, caspase 7, caspase-7, CMH-1, cystein aspartic-specific protease-7, DEVDase, ICE-LAP3, ICE-like apoptotic protease 3, LICE2 cysteine protease, More, SCA-2, SREBP cleavage activity 2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.60 caspase-7

Activating Compound

Activating Compound on EC 3.4.22.60 - caspase-7

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-(4-methoxyphenyl)-4-(piperazin-1-yl)quinoline
-
9% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM
2-(4-methoxyphenyl)-N-[2-(morpholin-4-yl)ethyl]quinolin-4-amine
-
4% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM
apoptosome complex
-
-
-
caspase 1
-
caspase-7 is cleaved and activated by caspase-1. This is mediated by flagellin and requires the host receptors Nlrc4 and Naip5
-
ceramide
-
-
cytolethal distending toxin
-
from Actinobacillus actinomycetemcomitans
-
etoposide
FSH
-
antiapoptotic effect on granulosa cells and a proapoptotic effect on theca-interstitial cells
gonadotropins
-
increases caspase-7 activity in both theca-interstitial cells and granulosa cells
-
LH
-
antiapoptotic effect on granulosa cells and a proapoptotic effect on theca-interstitial cells
-
N'-[2-(4-ethylphenyl)quinolin-4-yl]-N,N-dimethylethane-1,2-diamine
-
17% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM
N'-[2-(4-ethylphenyl)quinolin-4-yl]-N,N-dimethylpropane-1,3-diamine
-
26% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM
N'-[2-(4-methoxyphenyl)quinolin-4-yl]-N,N-dimethylethane-1,2-diamine
-
123% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM
N'-[2-(4-methoxyphenyl)quinolin-4-yl]-N,N-dimethylpropane-1,3-diamine
-
117% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM
N,N-diethyl-N'-[2-(4-ethylphenyl)quinolin-4-yl]propane-1,3-diamine
-
24% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM
N,N-diethyl-N'-[2-(4-methoxyphenyl)quinolin-4-yl]propane-1,3-diamine
-
124% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM
N6-(2-isopentenyl)adenosine
-
highly induces enzyme activation
nitric oxide
-
-
additional information
-