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Literature summary for 3.4.22.60 extracted from

  • Talanian, R.V.; Quinlan, C.; Trautz, S.; Hackett, M.C.; Mankovich, J.A.; Banach, D.; Ghayur, T.; Brady, K.D.; Wong, W.W.
    Substrate specificities of caspase family proteases (1997), J. Biol. Chem., 272, 9677-9682.
    View publication on PubMed
Search for more literature for 3.4.22.60

Inhibitors

Inhibitors Comment Organism Structure
acetyl-DEVD-aldehyde
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.012
-
 acetyl-DEVD-4-nitroanilide pH 7.5, 30°C Homo sapiens
0.125
-
 acetyl-VDQVDGW-amide pH 7.5, 30°C Homo sapiens
0.13
-
 acetyl-DQMD-4-nitroanilide pH 7.5, 30°C Homo sapiens
0.2
-
 acetyl-VDVAD-4-nitroanilide pH 7.5, 30°C Homo sapiens
0.49
-
 acetyl-YEVD-4-nitroanilide pH 7.5, 30°C Homo sapiens
0.57
-
 acetyl-YEID-4-nitroanilide pH 7.5, 30°C Homo sapiens
2.1
-
 acetyl-YQVD-4-nitroanilide pH 7.5, 30°C Homo sapiens
3.1
-
 acetyl-VDQQD-4-nitroanilide pH 7.5, 30°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-DEVD-4-nitroanilide + H2O
-
 Homo sapiens acetyl-DEVD + 4-nitroaniline
-
 ?
acetyl-DQMD-4-nitroanilide + H2O
-
 Homo sapiens acetyl-DQMD + 4-nitroaniline
-
 ?
acetyl-VDQQD-4-nitroanilide + H2O
-
 Homo sapiens acetyl-VDQQD + 4-nitroaniline
-
 ?
acetyl-VDQVDGW-amide + H2O preferred peptide substrate Homo sapiens ?
-
 ?
acetyl-VDVAD-4-nitroanilide + H2O
-
 Homo sapiens acetyl-VAVAD + 4-nitroaniline
-
 ?
acetyl-VEID-4-nitroanilide + H2O
-
 Homo sapiens acetyl-VEID + 4-nitroaniline
-
 ?
acetyl-VQVD-4-nitroanilide + H2O
-
 Homo sapiens acetyl-VQVD + 4-nitroaniline
-
 ?
acetyl-YEID-4-nitroanilide + H2O
-
 Homo sapiens acetyl-YEID + 4-nitroaniline
-
 ?
acetyl-YEVD-4-nitroanilide + H2O
-
 Homo sapiens acetyl-YEVD + 4-nitroaniline
-
 ?
acetyl-YQVD-4-nitroanilide + H2O
-
 Homo sapiens acetyl-YQVD + 4-nitroaniline
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000035
-
 acetyl-DEVD-aldehyde pH 7.5 Homo sapiens