Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of caspase-7 by using siRNAs results in the inhibition of Hep-G2 cell proliferation, but knockdown of other caspases does not show a significant effect on cell growth. The expression of His-tagged shRNA directed against caspase-7 induce the cell cycle arrest at mitosis, which is rescued by the re-expression of caspase-7 containing silent mutations at the target site for the shRNA | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | possible involvement of caspase-7 in cell cycle progression at mitosis, caspases including caspase-3, caspase-7, caspase-8 and caspase-9, are activated during mitosis and are potentially involved in the regulation at M phase. Chemically synthesized caspase inhibitors delay mitotic progression and induce accumulation of mitotic cells, which exhibits abnormal chromatin condensation and incomplete chromosome segregation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | possible involvement of caspase-7 in cell cycle progression at mitosis, caspases including caspase-3, caspase-7, caspase-8 and caspase-9, are activated during mitosis and are potentially involved in the regulation at M phase. Chemically synthesized caspase inhibitors delay mitotic progression and induce accumulation of mitotic cells, which exhibits abnormal chromatin condensation and incomplete chromosome segregation | Homo sapiens | ? | - |
? |