1.1.1.14: L-iditol 2-dehydrogenase

This is an abbreviated version, for detailed information about L-iditol 2-dehydrogenase, go to the full flat file.

Reaction

L-Iditol
+
NAD+
=
L-sorbose
+
NADH
+
H+

Synonyms

ADH, D-sorbitol dehydrogenase, dehydrogenase, L-iditol, Dgeo_2865, glucitol dehydrogenase, Hxt13, Hxt15, Hxt16, Hxt17, L-iditol 2-dehydrogenase, L-iditol dehydrogenase (sorbitol), L-iditol:NAD oxidoreductase, L-iditol:NAD+ 5-oxidoreductase, LeSDH, MdSDH5, More, NAD+-dependent sorbitol dehydrogenase, NAD-dependent polyol dehydrogenase, NAD-dependent sorbitol dehydrogenase, NAD-SDH, NAD-sorbitol dehydrogenase, PDH-11300, polyol dehydrogenase, Protein tms1, SDH, SldA, SLDH, Sor1, Sor2, sorbitol dehydrogenase, sorbitol transporter, SORD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.14 L-iditol 2-dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.14 - L-iditol 2-dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1,2-butanediol + NAD+
? + NADH + H+
show the reaction diagram
1,2-hexanediol + NAD+
? + NADH + H+
show the reaction diagram
3-deoxy-D-sorbitol + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
6-deoxy-D-sorbitol + NAD+
? + NADH
show the reaction diagram
-
nearly 2fold higher activity compared to D-sorbitol
-
-
?
6-fluoro-D-sorbitol + NAD+
? + NADH
show the reaction diagram
-
over 2fold higher activity compared to D-sorbitol, best substrate
-
-
?
D-adonitol + NAD+
D-ribulose + NADH
show the reaction diagram
-
-
-
-
?
D-arabinose + NADH
?
show the reaction diagram
D-arabitol + NAD(P)+
D-xylulose + NAD(P)H + H+
show the reaction diagram
D-arabitol + NAD+
?
show the reaction diagram
D-arabitol + NAD+
D-xylulose + NADH + H+
show the reaction diagram
D-fructose + NADH
?
show the reaction diagram
-
-
-
-
?
D-fructose + NADH + H+
D-sorbitol + NAD+
show the reaction diagram
D-galactitol + NAD+
D-tagatose + NADH
show the reaction diagram
D-galactitol + NAD+
D-tagatose + NADH + H+
show the reaction diagram
D-gluconate + NAD+
?
show the reaction diagram
-
low activity
-
-
?
D-glucose + NADH
?
show the reaction diagram
-
low activity
-
-
?
D-glycero-D-gluco-heptitol + NAD+
?
show the reaction diagram
-
-
-
-
?
D-mannitol + NAD(P)+
D-fructose + NAD(P)H + H+
show the reaction diagram
D-mannitol + NAD+
?
show the reaction diagram
D-mannitol + NAD+
D-fructose + NADH + H+
show the reaction diagram
D-mannose + NADH
?
show the reaction diagram
-
low activity
-
-
?
D-psicose + NADH
?
show the reaction diagram
-
-
-
-
?
D-raffinose + NADH
?
show the reaction diagram
-
low activity
-
-
?
D-ribitol + NAD+
?
show the reaction diagram
D-ribose + NADH
?
show the reaction diagram
-
low activity
-
-
?
D-ribulose + NADH
?
show the reaction diagram
D-sorbitol + 2,6-dichlorophenolindophenol
L-sorbose + ?
show the reaction diagram
-
electron acceptor: i.e. DCIP
-
-
?
D-sorbitol + NAD(P)+
L-sorbose + NAD(P)H + H+
show the reaction diagram
D-sorbitol + NAD+
? + NADH + H+
show the reaction diagram
-
-
-
-
?
D-sorbitol + NAD+
D-fructose + NADH + H+
show the reaction diagram
D-sorbitol + NAD+
L-sorbose + NADH + H+
show the reaction diagram
D-sorbitol + NADH + H+
D-fructose + NADH + H+
show the reaction diagram
D-sorbose + NADH
?
show the reaction diagram
-
low activity
-
-
?
D-tagatose + NADH
D-galactitol + NAD+
show the reaction diagram
D-xylitol + NAD+
?
show the reaction diagram
D-xylitol + NAD+
? + NADH + H+
show the reaction diagram
D-xylitol + NADP+
? + NADPH + H+
show the reaction diagram
NADP+ is not a cofactor for wild-type, but for a substrate-binding loop chimera
-
-
?
D-xylose + NADH
?
show the reaction diagram
D-xylulose + NADH
?
show the reaction diagram
erythritol + NAD+
?
show the reaction diagram
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
glycerol + NAD+
?
show the reaction diagram
-
low activity
-
-
?
glycerol + NAD+
dihydroxyacetone + NADH
show the reaction diagram
L-arabitol + NAD+
?
show the reaction diagram
L-erythrulose + NADH
?
show the reaction diagram
-
-
-
-
?
L-iditol + NAD+
?
show the reaction diagram
L-rhamnose + NADH
?
show the reaction diagram
-
low activity
-
-
?
L-sorbose + NADH
?
show the reaction diagram
L-threitol + NAD+
?
show the reaction diagram
meso-erythritol + NAD+
erythrulose + NADH
show the reaction diagram
-
high activity
-
-
?
ribitol + NAD+
?
show the reaction diagram
60% of the activity with D-sorbitol
-
-
?
sorbitol + NAD+
D-fructose + NADH
show the reaction diagram
Xylitol + NAD+
?
show the reaction diagram
29% of the activity with D-sorbitol
-
-
?
xylitol + NAD+
D-xylulose + NADH + H+
show the reaction diagram
-
-
-
r
additional information
?
-