1.1.1.14: L-iditol 2-dehydrogenase

This is an abbreviated version, for detailed information about L-iditol 2-dehydrogenase, go to the full flat file.

Reaction

L-Iditol
+
NAD+
=
L-sorbose
+
NADH
+
H+

Synonyms

ADH, D-sorbitol dehydrogenase, dehydrogenase, L-iditol, Dgeo_2865, glucitol dehydrogenase, Hxt13, Hxt15, Hxt16, Hxt17, L-iditol 2-dehydrogenase, L-iditol dehydrogenase (sorbitol), L-iditol:NAD oxidoreductase, L-iditol:NAD+ 5-oxidoreductase, LeSDH, MdSDH5, More, NAD+-dependent sorbitol dehydrogenase, NAD-dependent polyol dehydrogenase, NAD-dependent sorbitol dehydrogenase, NAD-SDH, NAD-sorbitol dehydrogenase, PDH-11300, polyol dehydrogenase, Protein tms1, SDH, SldA, SLDH, Sor1, Sor2, sorbitol dehydrogenase, sorbitol transporter, SORD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.14 L-iditol 2-dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.14 - L-iditol 2-dehydrogenase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2S)-1-(3-thio-2-methylpropionyl)-L-proline
-
-
1,10-phenanthroline
1,2,3,4,5,6-cyclohexanehexolphosphoric acid
-
at pH 9.9
-
1,2-dithioethane
-
-
-
1,7-phenanthroline
-
-
1-thiobutane
-
-
1-thioglycol
-
-
1-thiosorbitol
-
-
2,2'-dipyridyl
-
-
2,3-Dimercaptopropanol
-
-
2,3-Dithiopropanol
-
-
2-hydroxybenzoic acid
-
at pH 9.9
2-hydroxymethyl-4-(4-N,N-dimethylaminosulfonyl-1-piperazino)pyrimidine
2-mercaptoethanol
-
-
2-methyl-4-(4-N,N-dimethylaminosulfonyl-1-piperazino)pyrimidine
i.e. SDI-157
2-methypropanoic acid amide
-
at pH 9.9
2-propylpentanoic acid
-
at pH 9.9
2-thiobutane
-
-
3,4-dihydroxyphenyl-1-hydroxyacetic acid
3,4-dihydroxyphenyl-ethanediol
-
at pH 7.4
3-hydroxy-4-methoxy-phenyl-1-hydroxy-acetic acid
-
at pH 7.4
4,4'-dipyridyl
-
-
4-hydroxy-3-methoxy-phenyl-1-hydroxy-acetic acid
-
at pH 7.4
4-hydroxy-3-methoxy-phenylacetic acid
-
at pH 7.4
4-hydroxy-3-methoxy-phenylethanediol
-
at pH 7.4
4-hydroxy-3-methoxy-phenylethyl alcohol
8-hydroxyquinoline
-
-
acetic acid amide
-
at pH 9.9
ADP
-
2 mM, 72% activity
AgNO3
Alrestatin
-
-
AMP
-
2 mM, 83% activity
ATP
-
2 mM, 54% activity
Ba(CH3COO)2
-
1 mM reduces activity to about 20%
Berberine
-
-
bis-diethylthiocarbamoyldisulfide
-
-
butanedioic acid
-
at pH 9.9
CdCl2
-
1 mM
Cibacron Blue 3G-A
-
-
CoCl2
CP-642,931
-
a potent and specific sorbitol dehydrogenase inhibitor, rmacokinetics, biomarker pharmacodynamics, and safety analysis, overview. The inhibitor is rapidly absorbed through the oral route and effectively inhibits SDH. However, the drug is not well tolerated due to adverse neuromuscular effects. The inhibitor alters the red blood cell sorbitol dehydrogenase activity after oral administration
-
CuSO4
cyanamide
cyanide
-
-
cysteamine
-
significant only at pH 9.9
cysteine
D-fructose
D-sorbitol
-
above 49 mM, substrate inhibition
Decanoic acid
-
at pH 9.9
diethyldicarbonate
-
-
Diethylthiocarbamate
Disulfiram
-
-
dithioerythritol
-
protection at low concentration, inhibition at high concentration, 100 mM
dithiothreitol
DL-2-bromosuccinate
-
1 mM
DL-2-thiovaline
-
-
DTT
-
competitive and noncompetitive with respect to D-sorbitol and NAD+, respectively
Eriochrome Black T
-
-
ethanedioic acid
-
at pH 9.9
Fe2+
-
complete inhibition at 0.91 mM
FeSO4
-
1 mM
glutathione
-
-
HgCl2
ICI 171071
-
-
ICI 222155
-
-
imidazole
-
-
iodoacetamide
-
NADH 0.4 mM protects
iodoacetate
Isonicotinic acid hydrazide
-
-
KCl
-
0.1 M, inactivation
Mg2+
-
slightly inhibitory
MgCl2
MgSO4
-
1 mM
Mn2+
-
slightly inhibitory
monoiodoacetate
-
75% inhibition at 1.79 mM
N-bromosuccinimide
-
-
N-ethylmaleimide
-
1 mM
NiCl2
o-phenanthroline
-
-
p-chloromercuribenzoate
p-hydroxymercuribenzoate
-
-
Pb(CH3COO)2
-
-
Penicillamine
-
weak inhibition
ponalrestat
-
-
propanedioic acid
-
at pH 9.9
pyrazole
quercetin
quinine x HCl
-
slightly inhibitory, 25% inhibition at 1.79 mM
Semicarbazide
-
10 mM
thioacetate
-
at pH 9.9
Thiocyanate
Thiourea
-
at pH 9.9
Tolrestat
-
-
Urea
-
at pH 9.9
Valproic acid
-
weak inhibition
ZnSO4
additional information
-