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Literature summary for 1.1.1.14 extracted from

  • Cao, W.; Aghajanian, H.; Haig-Ladewig, L.; Gerton, G.
    Sorbitol can fuel mouse sperm motility and protein tyrosine phosphorylation via sorbitol dehydrogenase (2009), Biol. Reprod., 80, 124-133.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information SORD is associated with mitochondria and near the plasma membrane of the sperm flagellum, immunohistochemic analysis, overview Mus musculus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
39000
-
x * 39000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-sorbitol + NAD+ Mus musculus
-
D-fructose + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
CD1 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
cauda epididymidis
-
Mus musculus
-
additional information sorbitol can substitute for glucose or fructose in capacitating media Mus musculus
-
sperm SORD is present along the entire length of sperm flagellum, but does not show the same distribution pattern as alpha-tubulin. Sord mRNA and SORD protein expression is up-regulated during late spermiogenesis Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-sorbitol + NAD+
-
Mus musculus D-fructose + NADH + H+
-
?

Subunits

Subunits Comment Organism
? x * 39000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
sorbitol dehydrogenase
-
Mus musculus
SORD
-
Mus musculus

General Information

General Information Comment Organism
physiological function sorbitol dehydrogenase can convert sorbitol to fructose, which can then be metabolized via the glycolytic pathway in sperm to make ATP. Sorbitol can serve as an alternative energy source for sperm motility and protein tyrosine phosphorylation Mus musculus