1.1.1.14: L-iditol 2-dehydrogenase
This is an abbreviated version!
For detailed information about L-iditol 2-dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.14
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1.1.1.14
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polyols
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aminotransferase
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aldose
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hepatotoxicity
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fructose
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necrosis
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transaminase
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dehydrogenases
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bile
-
lens
-
alt
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sheep
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bilirubin
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gamma-glutamyl
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testicular
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cataract
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transpeptidase
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gluconobacter
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ccl4
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acetaminophen
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tetrachloride
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centrilobular
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xylitol
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oxydans
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hepatoprotective
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galactitol
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apap
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ribitol
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acetaminophen-induced
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diapause
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pneumotoxicity
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bromobenzene
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13-week
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n-demethylase
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d-mannitol
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forestomach
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hepatotoxicants
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fructokinase
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l-sorbose
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aminopyrine
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glutamic-pyruvic
-
sorbinil
-
medicine
-
agriculture
-
synthesis
- 1.1.1.14
- polyols
- aminotransferase
- aldose
-
hepatotoxicity
- fructose
- necrosis
- transaminase
- dehydrogenases
- bile
- lens
-
alt
- sheep
- bilirubin
-
gamma-glutamyl
- testicular
- cataract
- transpeptidase
- gluconobacter
- ccl4
- acetaminophen
-
tetrachloride
-
centrilobular
- xylitol
- oxydans
-
hepatoprotective
- galactitol
- apap
- ribitol
-
acetaminophen-induced
-
diapause
-
pneumotoxicity
- bromobenzene
-
13-week
- n-demethylase
- d-mannitol
-
forestomach
-
hepatotoxicants
- fructokinase
- l-sorbose
- aminopyrine
-
glutamic-pyruvic
- sorbinil
- medicine
- agriculture
- synthesis
Reaction
Synonyms
ADH, D-sorbitol dehydrogenase, dehydrogenase, L-iditol, Dgeo_2865, glucitol dehydrogenase, GoSCR, L-iditol 2-dehydrogenase, L-iditol dehydrogenase (sorbitol), L-iditol:NAD oxidoreductase, L-iditol:NAD+ 5-oxidoreductase, LeSDH, MdSDH5, More, NAD+-dependent sorbitol dehydrogenase, NAD-dependent polyol dehydrogenase, NAD-dependent sorbitol dehydrogenase, NAD-SDH, NAD-sorbitol dehydrogenase, PDH-11300, polyol dehydrogenase, Protein tms1, SDH, SldA, SLDH, SOR, Sor1, Sor2, sorbitol dehydrogenase, sorbitol dehydrogenase 1, sorbitol dehydrogenase 2, sorbitol related enzyme, SORD
ECTree
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Reference
Reference on EC 1.1.1.14 - L-iditol 2-dehydrogenase
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Leissing, N.; McGuinness, E.T.
Sorbitol dehydrogenase from rat liver
Methods Enzymol.
89
135-140
1982
Ovis aries, Rattus norvegicus
Jeffery, J.; Cummins, L.; Carlquist, M.; Jörnvall, H.
Properties of sorbitol dehydrogenase and characterization of a reactive cysteine residue reveal unexpected similarities to alcohol dehydrogenases
Eur. J. Biochem.
120
229-234
1981
Ovis aries
Negm, F.B.; Loescher, W.H.
Detection and characterization of sorbitol dehydrogenase from apple callus tissue
Plant Physiol.
64
69-73
1979
Malus domestica
Dooley, J.F.; Turnquist, L.J.; Racich, L.
Kinetic determination of serum sorbitol dehydrogenase activity with a centrifugal analyzer
Clin. Chem.
25
2026-2029
1979
Canis lupus familiaris, Homo sapiens, Mus musculus, Rattus norvegicus
Leissing, N.; Mc Guinness, E.T.
Rapid affinity purification and properties of rat liver sorbitol dehydrogenase
Biochim. Biophys. Acta
524
254-261
1978
Rattus norvegicus
Gerlach, U.; Hiby, W.
Sorbit-Dehydrogenase
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
1
601-606
1974
Homo sapiens, Rattus norvegicus
-
Myers, J.S.; Jakoby, W.B.
Effect of polyhydric alcohols on kinetic parameters of enzymes
Biochem. Biophys. Res. Commun.
51
631-636
1973
Ovis aries
Rehg, J.E.; Torack, R.M.
Partial purification and characterization of sorbitol dehydrogenase from rat brain
J. Neurochem.
28
655-660
1977
Rattus norvegicus
Williams-Ashman, H.G.; Banks, J.; Wolfson, S.K.
Oxidation of polyhydric alcohols by the prostate gland and seminal vesicle
Arch. Biochem. Biophys.
72
485-494
1957
Rattus norvegicus
King, T.E.; Mann, T.
Sorbitol metabolism in spermatozoa
Proc. R. Soc. Lond. B Biol. Sci.
151
226-243
1959
Cavia porcellus, Ovis aries
-
Bailey, J.P.; Renz, C.; McGuinness, E.T.
Sorbitol dehydrogenase from horse liver: Purification, characterization and comparative properties
Comp. Biochem. Physiol. B
69
909-914
1981
Equus caballus, Ovis aries
-
Rizzi, M.; Harwart, K.; Erlemann, P.; Bui-Thanh, N.A.; Dellweg, H.
Purification and properties of the NAD+-xylitol-dehydrogenase from the yeast Pichia stipitis
J. Ferment. Bioeng.
67
20-24
1989
Scheffersomyces stipitis
-
Rizzi, M.; Harwart, K.; Bui-Thanh, N.A.; Dellweg, H.
A kinetic study of the NAD+-xylitol-dehydrogenase from the yeast Pichia stipitis
J. Ferment. Bioeng.
67
25-30
1989
Scheffersomyces stipitis
-
Schneider, K.H.; Giffhorn, F.
Sorbitol dehydrogenase from Pseudomonas sp.: Purification, characterization and application to quantitative determination of sorbitol
Enzyme Microb. Technol.
13
332-337
1991
Pseudomonas sp.
-
Ng, K.; Ye, R.; Wu, X.C.; Wong, S.L.
Sorbitol dehydrogenase from Bacillus subtilis, purification, characterization and gene cloning
J. Biol. Chem.
267
24989-24994
1992
Bacillus subtilis
Yamaguchi, H.; Kanayama, Y.; Yamaki, S.
Purification and properties of NAD-dependent sorbitol dehydrogenase from apple fruit
Plant Cell Physiol.
35
887-892
1994
Malus domestica
-
Lindstad, R.I.; Hermansen, L.F.; McKinley-McKee, J.S.
Inhibition and activation studies on sheep liver sorbitol dehydrogenase
Eur. J. Biochem.
221
847-854
1994
Ovis aries
Schauder, S.; Schneider, K.H.; Giffhorn, F.
Polyol metabolism of Rhodobacter sphaeroides: biochemical characterization of a short-chain sorbitol dehydrogenase
Microbiology
141
1857-1863
1995
Cereibacter sphaeroides, Cereibacter sphaeroides Si4 / DSM 8371
Lindstad, R.I.; McKinley-McKee, J.S.
Effect of pH on sheep liver sorbitol dehydrogenase steady-state kinetics
Eur. J. Biochem.
233
891-898
1995
Ovis aries
Maret, W.
Human sorbitol dehydrogenase - a secondary alcohol dehydrogenase with distinct pathophysiological roles, pH dependent kinetic studies
Adv. Exp. Med. Biol.
383-393
1996
Homo sapiens
Kvernmo, T.; Winberg, J.O.; McKinley-McKee, J.S.
Reversible and irreversible inhibition of sheep liver sorbitol dehydrogenase with Cibaron Blue 3GA and Eriochrome Black T
Int. J. Biochem. Cell Biol.
28
303-309
1996
Ovis aries
Lindstad, R.I.; McKinley-McKee, J.S.
Reversible inhibition of sheep liver sorbitol dehydrogenase by thiol compounds
Eur. J. Biochem.
241
142-148
1996
Ovis aries
Marini, I.; Bucchioni, L.; Borella, P.; Del Corso, A.; Mura, U.
Sorbitol dehydrogenase from bovine lens: purification and properties
Arch. Biochem. Biophys.
340
383-391
1997
Bos taurus
Takayuki, U.
Purification and properties of NAD+-dependent sorbitol dehydrogenase from Bacillus fructosus
Biosci. Biotechnol. Biochem.
63
573-574
1999
Priestia megaterium
Adachi, O.; Toyama, H.; Theeragool, G.; Lotong, N.; Matsushita, K.
Crystallization and properties of NAD-dependent D-sorbitol dehydrogenase from Gluconobacter suboxydans IFO 3257
Biosci. Biotechnol. Biochem.
63
1589-1595
1999
Gluconobacter oxydans, Gluconobacter oxydans IFO3257
Marini, I.; Moschini, R.; Del Corso, A.; Mura, U.
Complete protection by alpha-crystallin of lens sorbitol dehydrogenase undergoing thermal stress
J. Biol. Chem.
275
32559-32565
2000
Bos taurus
Oura, Y.; Yamada, K.; Shiratake, K.; Yamaki, S.
Purification and characterization of NAD+-dependent sorbitol dehydrogenase from Japanese pear fruit
Phytochemistry
54
567-572
2000
Pyrus pyrifolia
Boguslawski, G.; Bertch, S.W.
A method for the assay of glucose isomerase activity in complex fermentation mixtures
J. Appl. Biochem.
2
367-372
1980
Ovis aries
-
Vongsuvanlert, V.; Tani, Y.
Characterization of D-sorbitol dehydrogenase involved in D-sorbitol production of a methanol yeast, Candida boidinii (Kloeckera sp.) No. 2201
Agric. Biol. Chem.
52
419-426
1988
[Candida] boidinii
-
Darmanin, C.; Iwata, T.; Carper, D.A.; Sparrow, L.G.; Chung, R.P.; El-Kabbani, O.
Expression, purification and preliminary crystallographic analysis of human sorbitol dehydrogenase
Acta Crystallogr. Sect. D
59
558-560
2003
Homo sapiens
Hoshino, T.; Sugisawa, T.; Shinjoh, M.; Tomiyama, N.; Miyazaki, T.
Membrane-bound D-sorbitol dehydrogenase of Gluconobacter suboxydans IFO 3255 - enzymatic and genetic characterization
Biochim. Biophys. Acta
1647
278-288
2003
Gluconobacter oxydans, Gluconobacter oxydans IFO 3255
Shinjoh, M.; Tomiyama, N.; Miyazaki, T.; Hoshino, T.
Main polyol dehydrogenase of Gluconobacter suboxydans IFO 3255, membrane-bound D-sorbitol dehydrogenase, that needs product of upstream gene, sldB, for activity
Biosci. Biotechnol. Biochem.
66
2314-2322
2002
Gluconobacter oxydans, Gluconobacter oxydans IFO 3255
Sugisawa, T.; Hoshino, T.
Purification and properties of membrane-bound D-sorbitol dehydrogenase from Gluconobacter suboxydans IFO 3255
Biosci. Biotechnol. Biochem.
66
57-64
2002
Gluconobacter oxydans, Gluconobacter oxydans IFO 3255
El-Kabbani, O.; Darmanin, C.; Chung, R.P.
Sorbitol dehydrogenase: structure, function and ligand design
Curr. Med. Chem.
11
465-476
2004
Ovis aries, Homo sapiens, Mammalia, Rattus norvegicus
Parmentier, S.; Arnaut, F.; Vandamme, E.J.
Gluconobacter NAD-dependent polyol dehydrogenase catalyzed production of D-sorbitol and D-mannitol with coenzyme regeneration
Meded. - Fac. Landbouwkd. Toegepaste Biol. Wet.
68
215-218
2003
Gluconobacter sp.
-
Nosarszewski, M.; Clements, A.M.; Downie, A.B.; Archbold, D.D.
Sorbitol dehydrogenase expression and activity during apple fruit set and early development
Physiol. Plant.
121
391-398
2004
Malus domestica (Q6EM42), Malus domestica (Q6EM45), Malus domestica (Q6EM46)
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Pauly, T.A.; Ekstrom, J.L.; Beebe, D.A.; Chrunyk, B.; Cunningham, D.; Griffor, M.; Kamath, A.; Lee, S.E.; Madura, R.; McGuire, D.; Subashi, T.; Wasilko, D.; Watts, P.; Mylari, B.L.; Oates, P.J.; Adams, P.D.; Rath, V.L.
X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase
Structure
11
1071-1085
2003
Homo sapiens (Q00796), Homo sapiens
Philippsen, A.; Schirmer, T.; Stein, M.A.; Giffhorn, F.; Stetefeld, J.
Structure of zinc-independent sorbitol dehydrogenase from Rhodobacter sphaeroides at 2.4 A resolution
Acta Crystallogr. Sect. D
D61
374-379
2005
Cereibacter sphaeroides
Marini, I.; Moschini, R.; Del Corso, A.; Mura, U.
alpha-Crystallin: an ATP-independent complete molecular chaperone toward sorbitol dehydrogenase
Cell. Mol. Life Sci.
62
599-605
2005
Bos taurus
Karacaoglan, V.; Ozer, I.
Steady-state kinetic properties of sorbitol dehydrogenase from chicken liver
Comp. Biochem. Physiol. B Biochem. Mol. Biol.
140
309-312
2005
Gallus gallus
Ohta, K.; Moriguchi, R.; Kanahama, K.; Yamaki, S.; Kanayama, Y.
Molecular evidence of sorbitol dehydrogenase in tomato, a non-Rosaceae plant
Phytochemistry
66
2822-2828
2005
Solanum lycopersicum (Q3C2L6), Solanum lycopersicum
Shibata, T.; Ichikawa, C.; Matsuura, M.; Takata, Y.; Noguchi, Y.; Saito, Y.; Yamashita, M.
Cloning of a gene for D-sorbitol dehydrogenase from Gluconobacter oxydans G624 and expression of the gene in Pseudomonas putida IFO3738
J. Biosci. Bioeng.
89
463-468
2000
Gluconobacter oxydans (Q9KWR5), Gluconobacter oxydans, Gluconobacter oxydans G624 (FERM BP-4415) (Q9KWR5), Gluconobacter oxydans G624 (FERM BP-4415)
Klimacek, M.; Hellmer, H.; Nidetzky, B.
Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu154-Cys forms of yeast xylitol dehydrogenase
Biochem. J.
404
421-429
2007
Ovis aries, Candida sp. HA 167
Hellgren, M.; Kaiser, C.; de Haij, S.; Norberg, A.; Hoeoeg, J.O.
A hydrogen-bonding network in mammalian sorbitol dehydrogenase stabilizes the tetrameric state and is essential for the catalytic power
Cell. Mol. Life Sci.
64
3129-3138
2007
Rattus norvegicus
Krezel, A.; Maret, W.
Thionein/metallothionein control Zn(II) availability and the activity of enzymes
J. Biol. Inorg. Chem.
13
401-409
2008
Ovis aries
Nosarzewski, M.; Archbold, D.D.
Tissue-specific expression of SORBITOL DEHYDROGENASE in apple fruit during early development
J. Exp. Bot.
58
1863-1872
2007
Malus domestica
Duangsrisai, S.; Yamada, K.; Bantog, N.A.; Shiratake, K.; Kanayama, Y.; Yamaki, S.
Presence and expression of NAD+-dependent sorbitol dehydrogenase and sorbitol-6-phosphate dehydrogenase genes in strawberry
J. Hortic. Sci. Biotechnol.
82
191-198
2007
Fragaria x ananassa
-
de Sousa, S.M.; Paniago, M.D.; Arruda, P.; Yunes, J.A.
Sugar levels modulate sorbitol dehydrogenase expression in maize
Plant Mol. Biol.
68
203-213
2008
Zea mays
Cao, W.; Aghajanian, H.; Haig-Ladewig, L.; Gerton, G.
Sorbitol can fuel mouse sperm motility and protein tyrosine phosphorylation via sorbitol dehydrogenase
Biol. Reprod.
80
124-133
2009
Mus musculus
Lanaspa, M.A.; Andres-Hernando, A.; Rivard, C.J.; Dai, Y.; Li, N.; Berl, T.
ZAC1 is up-regulated by hypertonicity and decreases sorbitol dehydrogenase expression, allowing accumulation of sorbitol in kidney cells
J. Biol. Chem.
284
19974-19981
2009
Homo sapiens, Mus musculus
Wang, X.L.; Xu, Y.H.; Peng, C.C.; Fan, R.C.; Gao, X.Q.
Ubiquitous distribution and different subcellular localization of sorbitol dehydrogenase in fruit and leaf of apple
J. Exp. Bot.
60
1025-1034
2009
Malus domestica (Q5I6M3), Malus domestica (Q5I6M4), Malus domestica
Landau, Z.; Novotny, M.J.; Preston, G.M.; Wright, K.; Freeman, T.; Dai, H.; Thompson, J.; Oates, P.J.; Calle, R.A.
Pharmacokinetics, pharmacodynamics, tolerability, and safety of a novel sorbitol dehydrogenase inhibitor in healthy participants
J. Clin. Pharmacol.
50
521-530
2010
Homo sapiens
Wulf, H.; Mallin, H.; Bornscheuer, U.
Protein engineering of a thermostable polyol dehydrogenase
Enzyme Microb. Technol.
51
217-224
2012
Deinococcus geothermalis (Q1J2J0), Deinococcus geothermalis, Deinococcus geothermalis DSM 11300 (Q1J2J0)
Selvaraj, C.; Krishnasamy, G.; Jagtap, S.; Patel, S.; Dhiman, S.; Kim, T.; Singh, S.; Lee, J.
Structural insights into the binding mode of D-sorbitol with sorbitol dehydrogenase using QM-polarized ligand docking and molecular dynamics simulations
Biochem. Eng. J.
114
244-256
2016
Gluconobacter oxydans (Q9KWR5)
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Adamczyk, J.; Deregowska, A.; Skoneczny, M.; Skoneczna, A.; Natkanska, U.; Kwiatkowska, A.; Rawska, E.; Potocki, L.; Kuna, E.; Panek, A.; Lewinska, A.; Wnuk, M.
Copy number variations of genes involved in stress responses reflect the redox state and DNA damage in brewing yeasts
Cell Stress Chaperones
21
849-864
2016
Saccharomyces cerevisiae (P35497), Saccharomyces cerevisiae (Q07786), Saccharomyces cerevisiae
Deregowska, A.; Skoneczny, M.; Adamczyk, J.; Kwiatkowska, A.; Rawska, E.; Skoneczna, A.; Lewinska, A.; Wnuk, M.
Genome-wide array-CGH analysis reveals YRF1 gene copy number variation that modulates genetic stability in distillery yeasts
Oncotarget
6
30650-30663
2015
Saccharomyces bayanus, Saccharomyces paradoxus, Saccharomyces kudriavzevii, Saccharomyces cerevisiae (P35497), Saccharomyces cerevisiae (Q07786)
Periyasamy, S.; Govindappa, N.; Sreenivas, S.; Sastry, K.
Isolation, characterization and evaluation of the Pichia pastoris sorbitol dehydrogenase promoter for expression of heterologous proteins
Protein Expr. Purif.
92
128-133
2013
Komagataella pastoris, Komagataella pastoris BICC 9450
Cui, Z.; Zhang, J.; Fan, X.; Zheng, G.; Chang, H.; Wei, W.
Highly efficient bioreduction of 2-hydroxyacetophenone to (S)- and (R)-1-phenyl-1,2-ethanediol by two substrate tolerance carbonyl reductases with cofactor regeneration
J. Biotechnol.
243
1-9
2017
Gluconobacter oxydans (Q5FNX9), Gluconobacter oxydans 621H (Q5FNX9)
Dong, F.; Wang, C.; Sun, X.; Bao, Z.; Dong, C.; Sun, C.; Ren, Y.; Liu, S.
Sugar metabolic changes in protein expression associated with different light quality combinations in tomato fruit
Plant Growth Regul.
88
267-282
2019
Solanum lycopersicum (Q3C2L6)
-
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