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Literature summary for 1.1.1.14 extracted from

  • Marini, I.; Moschini, R.; Del Corso, A.; Mura, U.
    Complete protection by alpha-crystallin of lens sorbitol dehydrogenase undergoing thermal stress (2000), J. Biol. Chem., 275, 32559-32565.
    View publication on PubMed

General Stability

General Stability Organism
alpha-crystallin stabilizes Bos taurus
bovine serum albumin stabilizes Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-fructose + NADH + H+
-
Bos taurus D-sorbitol + NAD+
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
18
-
50% loss of activity after 40 min, alpha-crystallin protects fully against activity loss Bos taurus
45
-
50% loss of activity after 20 min, alpha-crystallin protects fully against activity loss Bos taurus
55
-
50% loss of activity after 10 min, alpha-crystallin protects fully against activity loss Bos taurus
60
-
50% loss of activity after 5 min, alpha-crystallin reduces activity loss by 50% Bos taurus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Bos taurus
NADH
-
Bos taurus