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Literature summary for 1.1.1.14 extracted from

  • Smith, M.G.
    Polyol dehydrogenase (1962), Biochem. J., 83, 135-144.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Ovis aries

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Ovis aries
CuSO4
-
Ovis aries
cyanide
-
Ovis aries
cysteine at alkaline pH Ovis aries
glutathione
-
Ovis aries
p-chloromercuribenzoate
-
Ovis aries

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.18
-
D-xylitol
-
Ovis aries
0.6
-
NAD+
-
Ovis aries
1.1
-
D-sorbitol
-
Ovis aries
1.8
-
D-ribitol
-
Ovis aries

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
115000
-
ultracentrifugal analysis Ovis aries

Organism

Organism UniProt Comment Textmining
Ovis aries
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Ovis aries

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Ovis aries
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
14.4
-
-
Ovis aries

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glycero-D-gluco-heptitol + NAD+
-
Ovis aries ?
-
?
D-ribitol + NAD+
-
Ovis aries ?
-
?
D-sorbitol + NAD+
-
Ovis aries D-fructose + NADH + H+
-
?
D-xylitol + NAD+
-
Ovis aries ?
-
?
L-arabitol + NAD+
-
Ovis aries ?
-
?
L-iditol + NAD+
-
Ovis aries ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
D-fructose reduction Ovis aries
10
-
sorbitol oxidation Ovis aries

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Ovis aries
NADH
-
Ovis aries