BRENDA - Enzyme Database show
show all sequences of 1.1.1.14

Sorbitol dehydrogenase: structure, function and ligand design

El-Kabbani, O.; Darmanin, C.; Chung, R.P.; Curr. Med. Chem. 11, 465-476 (2004)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
D-sorbitol
at high concentration
Ovis aries
haloalcohols
at high concentration
Ovis aries
Application
Application
Commentary
Organism
medicine
target for inhibitor design in hyperglycaemia and diabetes mellitus treatment
Homo sapiens
medicine
target for inhibitor design
Mammalia
Crystallization (Commentary)
Crystallization
Organism
-
Homo sapiens
-
Rattus norvegicus
Inhibitors
Inhibitors
Commentary
Organism
Structure
1,2-dithioethane
-
Ovis aries
1-thiosorbitol
-
Ovis aries
2,3-Dithiopropanol
-
Ovis aries
2-hydroxymethyl-4-(4-N,N-dimethylaminosulfonyl-1-piperazino)pyrimidine
i.e. SDI-158
Homo sapiens
2-hydroxymethyl-4-(4-N,N-dimethylaminosulfonyl-1-piperazino)pyrimidine
i.e. SDI-158, inhibition mechanism, dissociation constants of enzyme-inhibitor complex at various pH values
Ovis aries
2-hydroxymethyl-4-(4-N,N-dimethylaminosulfonyl-1-piperazino)pyrimidine
i.e. SDI-158
Rattus norvegicus
3,4-dihydroxyphenyl-1-hydroxyacetic acid
weak inhibition
Ovis aries
4-hydroxy-3-methoxy-phenylethyl alcohol
-
Ovis aries
Berberine
-
Ovis aries
Cibacron Blue 3G-A
-
Ovis aries
cyanamide
weak inhibition
Ovis aries
D-fructose
at high concentration, product inhibition
Ovis aries
Diethylthiocarbamate
weak inhibition
Ovis aries
Disulfiram
-
Ovis aries
DTT
competitive and noncompetitive with respect to D-sorbitol and NAD+, respectively
Ovis aries
Eriochrome Black T
-
Ovis aries
additional information
drug design, inhibitory compounds
Homo sapiens
additional information
inhibition mechanism, poor inhibitors are 3,4-dihydroxyphenyl-ethandiol, imidazole, isobutyramide, and urea
Ovis aries
additional information
drug design, inhibitory compounds
Rattus norvegicus
NADH
at high concentration, product inhibition
Ovis aries
Penicillamine
weak inhibition
Ovis aries
pyrazole
weak inhibition
Ovis aries
quercetin
-
Ovis aries
Thiocyanate
weak inhibition
Ovis aries
Valproic acid
weak inhibition
Ovis aries
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
kinetic mechanism
Ovis aries
0.48
-
6-deoxy-D-sorbitol
-
Ovis aries
0.74
-
6-fluoro-D-sorbitol
-
Ovis aries
1.5
-
D-sorbitol
-
Ovis aries
1.9
-
3-deoxy-D-sorbitol
-
Ovis aries
11.7
-
4-fluoro-D-sorbitol
-
Ovis aries
15.5
-
2-deoxy-D-sorbitol
-
Ovis aries
15.5
-
2-fluoro-D-sorbitol
-
Ovis aries
15.5
-
3-fluoro-D-sorbitol
-
Ovis aries
26.4
-
4-deoxy-D-sorbitol
-
Ovis aries
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
bound
Homo sapiens
16020
-
membrane
bound
Mammalia
16020
-
membrane
bound
Ovis aries
16020
-
membrane
bound
Rattus norvegicus
16020
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Zn2+
1 catalytic zinc atom per subunit, interaction with Ser46 and the oxygen atom of the 2-hydroxy and the 4-hydroxy groups is important for substrate binding
Homo sapiens
Zn2+
1 catalytic zinc atom per subunit
Mammalia
Zn2+
1 catalytic zinc atom per subunit
Ovis aries
Zn2+
1 catalytic zinc atom per subunit, coordination in the active site
Rattus norvegicus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
37000
-
4 * 37000, about
Homo sapiens
37000
-
4 * 37000, about
Mammalia
37000
-
4 * 37000, about
Ovis aries
37000
-
4 * 37000, about
Rattus norvegicus
155000
-
about
Homo sapiens
155000
-
about
Mammalia
155000
-
about
Ovis aries
155000
-
about
Rattus norvegicus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
D-sorbitol + NAD+
Mammalia
second step of the polyol pathway of glucose metabolism
D-fructose + NADH + H+
-
-
?
D-sorbitol + NAD+
Rattus norvegicus
second step of the polyol pathway of glucose metabolism
D-fructose + NADH + H+
-
-
?
D-sorbitol + NAD+
Ovis aries
second step of the polyol pathway of glucose metabolism
D-fructose + NADH + H+
-
-
?
D-sorbitol + NAD+
Homo sapiens
second step of the polyol pathway of glucose metabolism, important in diabetic disease and hyperglycaemia
D-fructose + NADH + H+
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Mammalia
-
-
-
Ovis aries
-
-
-
Rattus norvegicus
-
-
-
Reaction
Reaction
Commentary
Organism
L-iditol + NAD+ = L-sorbose + NADH + H+
ordered catalytic mechanism and substrate binding
Homo sapiens
L-iditol + NAD+ = L-sorbose + NADH + H+
ordered catalytic mechanism and substrate binding
Mammalia
L-iditol + NAD+ = L-sorbose + NADH + H+
ordered catalytic mechanism and substrate binding, active site structure
Ovis aries
L-iditol + NAD+ = L-sorbose + NADH + H+
ordered catalytic mechanism and substrate binding
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Mammalia
-
erythrocyte
-
Mammalia
-
erythrocyte
-
Homo sapiens
-
lens
-
Mammalia
-
liver
-
Homo sapiens
-
liver
-
Mammalia
-
liver
-
Ovis aries
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-deoxy-D-sorbitol + NAD+
-
655289
Ovis aries
? + NADH
-
-
-
?
6-deoxy-D-sorbitol + NAD+
nearly 2fold higher activity compared to D-sorbitol
655289
Ovis aries
? + NADH
-
-
-
?
6-fluoro-D-sorbitol + NAD+
over 2fold higher activity compared to D-sorbitol, best substrate
655289
Ovis aries
? + NADH
-
-
-
?
D-sorbitol + NAD+
second step of the polyol pathway of glucose metabolism
655289
Mammalia
D-fructose + NADH + H+
-
-
-
?
D-sorbitol + NAD+
second step of the polyol pathway of glucose metabolism
655289
Rattus norvegicus
D-fructose + NADH + H+
-
-
-
?
D-sorbitol + NAD+
second step of the polyol pathway of glucose metabolism
655289
Ovis aries
D-fructose + NADH + H+
-
-
-
?
D-sorbitol + NAD+
second step of the polyol pathway of glucose metabolism, important in diabetic disease and hyperglycaemia
655289
Homo sapiens
D-fructose + NADH + H+
-
-
-
?
D-sorbitol + NAD+
i.e. D-glucitol, dissociation of the enzyme-coenzyme binary complex is the rate-limiting step
655289
Mammalia
D-fructose + NADH + H+
-
-
-
?
D-sorbitol + NAD+
i.e. D-glucitol, dissociation of the enzyme-coenzyme binary complex is the rate-limiting step
655289
Rattus norvegicus
D-fructose + NADH + H+
-
-
-
?
D-sorbitol + NAD+
i.e. D-glucitol, dissociation of the enzyme-coenzyme binary complex is the rate-limiting step, 2- and 4-hydroxy groups of D-sorbitol are important for substrate bindig
655289
Ovis aries
D-fructose + NADH + H+
-
-
-
?
D-sorbitol + NAD+
i.e. D-glucitol, dissociation of the enzyme-coenzyme binary complex is the rate-limiting step, interaction of Zn2+ with Ser46 and the oxygen atom of the 2-hydroxy and the 4-hydroxy groups is important for substrate binding
655289
Homo sapiens
D-fructose + NADH + H+
-
-
-
?
additional information
no activity with 2-deoxy-D-sorbitol and 2-fluoro-D-sorbitol, 3-fluoro-D-sorbitol and 4-fluoro-D-sorbitol are poor substrates
655289
Ovis aries
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
More
structure model
Ovis aries
More
3D-strcuture
Rattus norvegicus
tetramer
4 * 37000, about
Homo sapiens
tetramer
4 * 37000, about
Mammalia
tetramer
4 * 37000, about
Ovis aries
tetramer
4 * 37000, about
Rattus norvegicus
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
129
-
4-deoxy-D-sorbitol
-
Ovis aries
274
-
6-deoxy-D-sorbitol
-
Ovis aries
350
-
3-fluoro-D-sorbitol
-
Ovis aries
354
-
4-fluoro-D-sorbitol
-
Ovis aries
441
-
3-deoxy-D-sorbitol
-
Ovis aries
506
-
D-sorbitol
-
Ovis aries
559
-
6-fluoro-D-sorbitol
-
Ovis aries
pH Range
pH Minimum
pH Maximum
Commentary
Organism
additional information
-
-
Ovis aries
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
Lys294 is important in cofactor binding
Homo sapiens
NAD+
-
Mammalia
NAD+
-
Rattus norvegicus
NAD+
-
Ovis aries
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
additional information
-
additional information
inhibition kinetics at different pH
Ovis aries
0.00023
-
2-hydroxymethyl-4-(4-N,N-dimethylaminosulfonyl-1-piperazino)pyrimidine
-
Rattus norvegicus
0.00025
-
2-hydroxymethyl-4-(4-N,N-dimethylaminosulfonyl-1-piperazino)pyrimidine
-
Homo sapiens
0.007
-
2,3-Dithiopropanol
pH 9.9
Ovis aries
0.0075
-
Disulfiram
pH 9.9
Ovis aries
0.022
-
Cibacron Blue 3G-A
pH 9.9
Ovis aries
0.025
-
Berberine
pH 9.9
Ovis aries
0.026
-
1,2-dithioethane
pH 9.9
Ovis aries
0.029
-
Eriochrome Black T
pH 9.9
Ovis aries
0.072
-
quercetin
pH 9.9
Ovis aries
0.34
-
1-thiosorbitol
pH 9.9
Ovis aries
1.7
-
4-hydroxy-3-methoxy-phenylethyl alcohol
pH 9.9
Ovis aries
4.5
-
Valproic acid
pH 9.9
Ovis aries
10
-
cyanamide
pH 9.9
Ovis aries
11
-
Diethylthiocarbamate
pH 9.9
Ovis aries
13
-
Penicillamine
pH 9.9
Ovis aries
22
-
Thiocyanate
pH 9.9
Ovis aries
28
-
pyrazole
pH 9.9
Ovis aries
35
-
3,4-dihydroxyphenyl-1-hydroxyacetic acid
pH 9.9
Ovis aries
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
D-sorbitol
at high concentration
Ovis aries
haloalcohols
at high concentration
Ovis aries
Application (protein specific)
Application
Commentary
Organism
medicine
target for inhibitor design in hyperglycaemia and diabetes mellitus treatment
Homo sapiens
medicine
target for inhibitor design
Mammalia
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
Lys294 is important in cofactor binding
Homo sapiens
NAD+
-
Mammalia
NAD+
-
Rattus norvegicus
NAD+
-
Ovis aries
Crystallization (Commentary) (protein specific)
Crystallization
Organism
-
Homo sapiens
-
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
1,2-dithioethane
-
Ovis aries
1-thiosorbitol
-
Ovis aries
2,3-Dithiopropanol
-
Ovis aries
2-hydroxymethyl-4-(4-N,N-dimethylaminosulfonyl-1-piperazino)pyrimidine
i.e. SDI-158
Homo sapiens
2-hydroxymethyl-4-(4-N,N-dimethylaminosulfonyl-1-piperazino)pyrimidine
i.e. SDI-158, inhibition mechanism, dissociation constants of enzyme-inhibitor complex at various pH values
Ovis aries
2-hydroxymethyl-4-(4-N,N-dimethylaminosulfonyl-1-piperazino)pyrimidine
i.e. SDI-158
Rattus norvegicus
3,4-dihydroxyphenyl-1-hydroxyacetic acid
weak inhibition
Ovis aries
4-hydroxy-3-methoxy-phenylethyl alcohol
-
Ovis aries
Berberine
-
Ovis aries
Cibacron Blue 3G-A
-
Ovis aries
cyanamide
weak inhibition
Ovis aries
D-fructose
at high concentration, product inhibition
Ovis aries
Diethylthiocarbamate
weak inhibition
Ovis aries
Disulfiram
-
Ovis aries
DTT
competitive and noncompetitive with respect to D-sorbitol and NAD+, respectively
Ovis aries
Eriochrome Black T
-
Ovis aries
additional information
drug design, inhibitory compounds
Homo sapiens
additional information
inhibition mechanism, poor inhibitors are 3,4-dihydroxyphenyl-ethandiol, imidazole, isobutyramide, and urea
Ovis aries
additional information
drug design, inhibitory compounds
Rattus norvegicus
NADH
at high concentration, product inhibition
Ovis aries
Penicillamine
weak inhibition
Ovis aries
pyrazole
weak inhibition
Ovis aries
quercetin
-
Ovis aries
Thiocyanate
weak inhibition
Ovis aries
Valproic acid
weak inhibition
Ovis aries
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
additional information
-
additional information
inhibition kinetics at different pH
Ovis aries
0.00023
-
2-hydroxymethyl-4-(4-N,N-dimethylaminosulfonyl-1-piperazino)pyrimidine
-
Rattus norvegicus
0.00025
-
2-hydroxymethyl-4-(4-N,N-dimethylaminosulfonyl-1-piperazino)pyrimidine
-
Homo sapiens
0.007
-
2,3-Dithiopropanol
pH 9.9
Ovis aries
0.0075
-
Disulfiram
pH 9.9
Ovis aries
0.022
-
Cibacron Blue 3G-A
pH 9.9
Ovis aries
0.025
-
Berberine
pH 9.9
Ovis aries
0.026
-
1,2-dithioethane
pH 9.9
Ovis aries
0.029
-
Eriochrome Black T
pH 9.9
Ovis aries
0.072
-
quercetin
pH 9.9
Ovis aries
0.34
-
1-thiosorbitol
pH 9.9
Ovis aries
1.7
-
4-hydroxy-3-methoxy-phenylethyl alcohol
pH 9.9
Ovis aries
4.5
-
Valproic acid
pH 9.9
Ovis aries
10
-
cyanamide
pH 9.9
Ovis aries
11
-
Diethylthiocarbamate
pH 9.9
Ovis aries
13
-
Penicillamine
pH 9.9
Ovis aries
22
-
Thiocyanate
pH 9.9
Ovis aries
28
-
pyrazole
pH 9.9
Ovis aries
35
-
3,4-dihydroxyphenyl-1-hydroxyacetic acid
pH 9.9
Ovis aries
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
kinetic mechanism
Ovis aries
0.48
-
6-deoxy-D-sorbitol
-
Ovis aries
0.74
-
6-fluoro-D-sorbitol
-
Ovis aries
1.5
-
D-sorbitol
-
Ovis aries
1.9
-
3-deoxy-D-sorbitol
-
Ovis aries
11.7
-
4-fluoro-D-sorbitol
-
Ovis aries
15.5
-
2-deoxy-D-sorbitol
-
Ovis aries
15.5
-
2-fluoro-D-sorbitol
-
Ovis aries
15.5
-
3-fluoro-D-sorbitol
-
Ovis aries
26.4
-
4-deoxy-D-sorbitol
-
Ovis aries
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
bound
Homo sapiens
16020
-
membrane
bound
Mammalia
16020
-
membrane
bound
Ovis aries
16020
-
membrane
bound
Rattus norvegicus
16020
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Zn2+
1 catalytic zinc atom per subunit, interaction with Ser46 and the oxygen atom of the 2-hydroxy and the 4-hydroxy groups is important for substrate binding
Homo sapiens
Zn2+
1 catalytic zinc atom per subunit
Mammalia
Zn2+
1 catalytic zinc atom per subunit
Ovis aries
Zn2+
1 catalytic zinc atom per subunit, coordination in the active site
Rattus norvegicus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
37000
-
4 * 37000, about
Homo sapiens
37000
-
4 * 37000, about
Mammalia
37000
-
4 * 37000, about
Ovis aries
37000
-
4 * 37000, about
Rattus norvegicus
155000
-
about
Homo sapiens
155000
-
about
Mammalia
155000
-
about
Ovis aries
155000
-
about
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
D-sorbitol + NAD+
Mammalia
second step of the polyol pathway of glucose metabolism
D-fructose + NADH + H+
-
-
?
D-sorbitol + NAD+
Rattus norvegicus
second step of the polyol pathway of glucose metabolism
D-fructose + NADH + H+
-
-
?
D-sorbitol + NAD+
Ovis aries
second step of the polyol pathway of glucose metabolism
D-fructose + NADH + H+
-
-
?
D-sorbitol + NAD+
Homo sapiens
second step of the polyol pathway of glucose metabolism, important in diabetic disease and hyperglycaemia
D-fructose + NADH + H+
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Mammalia
-
erythrocyte
-
Mammalia
-
erythrocyte
-
Homo sapiens
-
lens
-
Mammalia
-
liver
-
Homo sapiens
-
liver
-
Mammalia
-
liver
-
Ovis aries
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-deoxy-D-sorbitol + NAD+
-
655289
Ovis aries
? + NADH
-
-
-
?
6-deoxy-D-sorbitol + NAD+
nearly 2fold higher activity compared to D-sorbitol
655289
Ovis aries
? + NADH
-
-
-
?
6-fluoro-D-sorbitol + NAD+
over 2fold higher activity compared to D-sorbitol, best substrate
655289
Ovis aries
? + NADH
-
-
-
?
D-sorbitol + NAD+
second step of the polyol pathway of glucose metabolism
655289
Mammalia
D-fructose + NADH + H+
-
-
-
?
D-sorbitol + NAD+
second step of the polyol pathway of glucose metabolism
655289
Rattus norvegicus
D-fructose + NADH + H+
-
-
-
?
D-sorbitol + NAD+
second step of the polyol pathway of glucose metabolism
655289
Ovis aries
D-fructose + NADH + H+
-
-
-
?
D-sorbitol + NAD+
second step of the polyol pathway of glucose metabolism, important in diabetic disease and hyperglycaemia
655289
Homo sapiens
D-fructose + NADH + H+
-
-
-
?
D-sorbitol + NAD+
i.e. D-glucitol, dissociation of the enzyme-coenzyme binary complex is the rate-limiting step
655289
Mammalia
D-fructose + NADH + H+
-
-
-
?
D-sorbitol + NAD+
i.e. D-glucitol, dissociation of the enzyme-coenzyme binary complex is the rate-limiting step
655289
Rattus norvegicus
D-fructose + NADH + H+
-
-
-
?
D-sorbitol + NAD+
i.e. D-glucitol, dissociation of the enzyme-coenzyme binary complex is the rate-limiting step, 2- and 4-hydroxy groups of D-sorbitol are important for substrate bindig
655289
Ovis aries
D-fructose + NADH + H+
-
-
-
?
D-sorbitol + NAD+
i.e. D-glucitol, dissociation of the enzyme-coenzyme binary complex is the rate-limiting step, interaction of Zn2+ with Ser46 and the oxygen atom of the 2-hydroxy and the 4-hydroxy groups is important for substrate binding
655289
Homo sapiens
D-fructose + NADH + H+
-
-
-
?
additional information
no activity with 2-deoxy-D-sorbitol and 2-fluoro-D-sorbitol, 3-fluoro-D-sorbitol and 4-fluoro-D-sorbitol are poor substrates
655289
Ovis aries
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
More
structure model
Ovis aries
More
3D-strcuture
Rattus norvegicus
tetramer
4 * 37000, about
Homo sapiens
tetramer
4 * 37000, about
Mammalia
tetramer
4 * 37000, about
Ovis aries
tetramer
4 * 37000, about
Rattus norvegicus
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
129
-
4-deoxy-D-sorbitol
-
Ovis aries
274
-
6-deoxy-D-sorbitol
-
Ovis aries
350
-
3-fluoro-D-sorbitol
-
Ovis aries
354
-
4-fluoro-D-sorbitol
-
Ovis aries
441
-
3-deoxy-D-sorbitol
-
Ovis aries
506
-
D-sorbitol
-
Ovis aries
559
-
6-fluoro-D-sorbitol
-
Ovis aries
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
additional information
-
-
Ovis aries
Other publictions for EC 1.1.1.14
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737257
Jordan
Hxt13, Hxt15, Hxt16 and Hxt17 ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508
Sci. Rep.
6
0000
2016
-
-
-
-
-
-
-
2
-
-
-
16
-
14
-
-
-
-
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
16
-
-
-
-
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
736022
Wulf
Protein engineering of a therm ...
Deinococcus geothermalis, Deinococcus geothermalis DSM 11300
Enzyme Microb. Technol.
51
217-224
2012
-
-
1
-
2
-
-
3
-
-
-
-
-
5
-
-
-
-
-
-
5
-
11
-
1
-
2
4
-
-
-
2
-
-
-
-
-
1
2
-
2
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
5
-
11
-
1
-
2
4
-
-
-
-
-
-
-
-
4
4
712908
Landau
Pharmacokinetics, pharmacodyna ...
Homo sapiens
J. Clin. Pharmacol.
50
521-530
2010
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
711357
Cao
Sorbitol can fuel mouse sperm ...
Mus musculus
Biol. Reprod.
80
124-133
2009
-
-
-
-
-
-
-
-
1
-
1
1
-
3
-
-
-
-
-
4
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
-
4
-
-
1
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
712376
Lanaspa
ZAC1 is up-regulated by hypert ...
Homo sapiens, Mus musculus
J. Biol. Chem.
284
19974-19981
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
2
2
2
2
-
-
712606
Wang
Ubiquitous distribution and di ...
Malus domestica
J. Exp. Bot.
60
1025-1034
2009
-
-
1
-
-
-
-
-
4
-
-
-
-
5
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
1
2
-
-
-
687821
Krezel
Thionein/metallothionein contr ...
Ovis aries
J. Biol. Inorg. Chem.
13
401-409
2008
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689569
de Sousa
Sugar levels modulate sorbitol ...
Zea mays
Plant Mol. Biol.
68
203-213
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684974
Klimacek
Catalytic mechanism of Zn2+-de ...
Candida sp. HA 167, Ovis aries
Biochem. J.
404
421-429
2007
-
-
1
-
1
-
-
6
-
2
-
-
-
5
-
-
-
-
-
3
-
-
2
-
-
-
-
3
-
-
-
4
-
-
-
-
-
1
4
-
1
-
-
-
-
6
-
2
-
-
-
-
-
-
-
3
-
-
2
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
686021
Hellgren
A hydrogen-bonding network in ...
Rattus norvegicus
Cell. Mol. Life Sci.
64
3129-3138
2007
-
-
-
-
1
-
-
2
-
-
4
-
-
1
-
-
-
-
-
-
-
-
3
4
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
3
4
-
-
-
2
-
-
-
-
-
-
-
-
-
-
688074
Nosarzewski
Tissue-specific expression of ...
Malus domestica
J. Exp. Bot.
58
1863-1872
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
688138
Duangsrisai
-
Presence and expression of NAD ...
Fragaria x ananassa
J. Hortic. Sci. Biotechnol.
82
191-198
2007
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
-
-
-
3
-
-
-
1
-
-
-
-
-
-
-
1
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
3
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
667062
Philippsen
Structure of zinc-independent ...
Rhodobacter sphaeroides
Acta Crystallogr. Sect. D
D61
374-379
2005
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668225
Marini
alpha-Crystallin: an ATP-indep ...
Bos taurus
Cell. Mol. Life Sci.
62
599-605
2005
-
-
-
-
-
1
-
-
-
-
-
-
-
3
-
-
-
-
1
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668325
Karacaoglan
Steady-state kinetic propertie ...
Gallus gallus
Comp. Biochem. Physiol. B Biochem. Mol. Biol.
140
309-312
2005
-
-
-
-
-
-
2
4
-
-
-
-
-
3
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
2
2
-
-
-
-
-
2
-
-
-
-
2
2
4
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670513
Ohta
Molecular evidence of sorbitol ...
Solanum lycopersicum
Phytochemistry
66
2822-2828
2005
-
-
1
-
-
-
-
2
-
-
-
-
-
5
-
-
-
-
-
1
-
-
7
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
7
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
655289
El-Kabbani
Sorbitol dehydrogenase: struct ...
Homo sapiens, Mammalia, Ovis aries, Rattus norvegicus
Curr. Med. Chem.
11
465-476
2004
2
2
-
2
-
-
25
10
4
4
8
4
-
4
-
-
-
4
-
7
-
-
12
6
-
-
-
7
-
1
-
4
19
-
-
2
2
-
4
2
-
-
-
25
19
10
4
4
8
4
-
-
-
-
-
7
-
-
12
6
-
-
-
7
-
1
-
-
-
-
-
-
-
-
656930
Nosarszewski
-
Sorbitol dehydrogenase express ...
Malus domestica
Physiol. Plant.
121
391-398
2004
-
-
1
-
-
-
-
-
-
-
1
1
-
3
-
-
-
-
-
2
-
-
2
1
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
2
-
-
2
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
654090
Darmanin
Expression, purification and p ...
Homo sapiens
Acta Crystallogr. Sect. D
59
558-560
2003
-
-
1
1
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
1
1
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
654867
Hoshino
Membrane-bound D-sorbitol dehy ...
Gluconobacter oxydans, Gluconobacter oxydans IFO 3255
Biochim. Biophys. Acta
1647
278-288
2003
1
1
1
-
1
-
-
-
1
-
1
2
-
7
-
-
-
-
-
-
-
-
6
2
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
1
-
-
-
-
-
1
-
1
2
-
-
-
-
-
-
-
-
6
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
656694
Parmentier
-
Gluconobacter NAD-dependent po ...
Gluconobacter sp.
Meded. - Fac. Landbouwkd. Toegepaste Biol. Wet.
68
215-218
2003
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
2
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
657360
Pauly
X-ray crystallographic and kin ...
Homo sapiens
Structure
11
1071-1085
2003
-
-
-
1
-
-
2
-
-
1
-
1
-
2
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
1
-
-
-
2
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
655022
Shinjoh
Main polyol dehydrogenase of G ...
Gluconobacter oxydans, Gluconobacter oxydans IFO 3255
Biosci. Biotechnol. Biochem.
66
2314-2322
2002
1
-
1
-
1
-
-
-
1
-
-
2
-
4
-
-
-
-
-
-
1
-
4
-
1
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
1
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
655030
Sugisawa
Purification and properties of ...
Gluconobacter oxydans, Gluconobacter oxydans IFO
Biosci. Biotechnol. Biochem.
66
57-64
2002
-
-
-
-
-
1
8
1
1
1
1
-
-
5
-
-
1
-
-
-
1
-
14
1
1
1
4
-
1
-
-
1
-
-
-
-
-
-
1
-
-
1
-
8
-
1
1
1
1
-
-
-
-
1
-
-
1
-
14
1
1
1
4
-
1
-
-
-
-
-
-
-
-
-
285898
Marini
Complete protection by alpha-c ...
Bos taurus
J. Biol. Chem.
275
32559-32565
2000
-
-
-
-
-
2
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
4
-
-
-
-
2
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
285899
Oura
Purification and characterizat ...
Pyrus pyrifolia
Phytochemistry
54
567-572
2000
1
-
-
-
-
-
4
-
-
-
-
-
-
6
-
-
1
-
-
2
1
-
8
-
-
-
-
-
1
2
-
2
-
-
-
1
-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
-
-
1
-
2
1
-
8
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
680957
Shibata
Cloning of a gene for D-sorbit ...
Gluconobacter oxydans, Gluconobacter oxydans G624 (FERM BP-4415)
J. Biosci. Bioeng.
89
463-468
2000
-
-
1
-
-
-
-
1
-
-
1
-
-
7
-
-
1
-
-
-
-
1
8
-
-
-
-
-
2
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
1
-
-
1
-
-
-
-
1
-
-
-
1
8
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
285896
Takayuki
Purification and properties of ...
Bacillus megaterium
Biosci. Biotechnol. Biochem.
63
573-574
1999
-
-
-
1
-
-
4
2
-
-
-
-
-
1
-
-
1
-
-
-
1
-
1
-
-
-
2
-
-
-
1
2
-
-
-
-
-
-
2
1
-
-
-
4
-
2
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
285897
Adachi
Crystallization and properties ...
Gluconobacter oxydans, Gluconobacter oxydans IFO3257
Biosci. Biotechnol. Biochem.
63
1589-1595
1999
-
-
-
-
-
-
-
4
-
-
1
-
-
2
-
-
1
-
-
-
1
1
10
1
-
-
2
-
2
-
1
2
-
-
-
-
-
-
2
-
-
-
-
-
-
4
-
-
1
-
-
-
-
1
-
-
1
1
10
1
-
-
2
-
2
-
1
-
-
-
-
-
-
-
285895
Marini
Sorbitol dehydrogenase from bo ...
Bos taurus
Arch. Biochem. Biophys.
340
383-391
1997
-
-
-
-
-
1
3
11
-
1
2
-
-
2
-
-
1
-
-
2
1
1
9
1
-
-
-
-
2
-
-
2
-
-
-
-
-
-
2
-
-
1
-
3
-
11
-
1
2
-
-
-
-
1
-
2
1
1
9
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
285892
Maret
Human sorbitol dehydrogenase - ...
Homo sapiens
Adv. Exp. Med. Biol.
383-393
1996
-
-
-
-
-
-
-
5
-
-
-
-
-
1
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
1
2
-
-
-
-
-
-
2
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
285893
Kvernmo
Reversible and irreversible in ...
Ovis aries
Int. J. Biochem. Cell Biol.
28
303-309
1996
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285894
Lindstad
Reversible inhibition of sheep ...
Ovis aries
Eur. J. Biochem.
241
142-148
1996
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285890
Schauder
Polyol metabolism of Rhodobact ...
Rhodobacter sphaeroides, Rhodobacter sphaeroides Si4
Microbiology
141
1857-1863
1995
-
-
-
-
-
2
2
6
-
-
2
-
-
5
-
-
1
-
-
-
1
1
16
1
-
-
3
-
2
2
-
2
-
-
-
-
-
-
2
-
-
2
-
2
-
6
-
-
2
-
-
-
-
1
-
-
1
1
16
1
-
-
3
-
2
2
-
-
-
-
-
-
-
-
285891
Lindstad
Effect of pH on sheep liver so ...
Ovis aries
Eur. J. Biochem.
233
891-898
1995
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
285888
Yamaguchi
-
Purification and properties of ...
Malus domestica
Plant Cell Physiol.
35
887-892
1994
-
-
-
-
-
-
4
2
-
-
1
-
-
1
-
-
-
-
-
1
1
-
8
-
-
-
-
-
2
2
-
2
-
-
-
-
-
-
2
-
-
-
-
4
-
2
-
-
1
-
-
-
-
-
-
1
1
-
8
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
285889
Lindstad
Inhibition and activation stud ...
Ovis aries
Eur. J. Biochem.
221
847-854
1994
15
-
-
-
-
-
52
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
15
-
-
2
-
-
-
-
52
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285887
Ng
Sorbitol dehydrogenase from Ba ...
Bacillus subtilis
J. Biol. Chem.
267
24989-24994
1992
-
-
1
-
-
-
-
6
-
1
2
-
-
5
-
-
1
-
-
-
1
-
6
1
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
6
-
1
2
-
-
-
-
1
-
-
1
-
6
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285886
Schneider
-
Sorbitol dehydrogenase from Ps ...
Pseudomonas sp.
Enzyme Microb. Technol.
13
332-337
1991
1
-
-
-
-
1
10
6
-
-
2
-
-
1
-
-
1
-
-
-
1
-
12
1
-
-
5
-
2
-
-
2
-
-
-
1
-
-
2
-
-
1
-
10
-
6
-
-
2
-
-
-
-
1
-
-
1
-
12
1
-
-
5
-
2
-
-
-
-
-
-
-
-
-
285884
Rizzi
-
Purification and properties of ...
Scheffersomyces stipitis
J. Ferment. Bioeng.
67
20-24
1989
-
-
-
-
-
-
3
2
-
-
2
1
-
1
-
-
1
-
-
-
1
1
9
1
1
1
-
-
1
1
-
2
-
-
-
-
-
-
2
-
-
-
-
3
-
2
-
-
2
1
-
-
-
1
-
-
1
1
9
1
1
1
-
-
1
1
-
-
-
-
-
-
-
-
285885
Rizzi
-
A kinetic study of the NAD+-xy ...
Scheffersomyces stipitis
J. Ferment. Bioeng.
67
25-30
1989
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285901
Vongsuvanlert
-
Characterization of D-sorbitol ...
Candida boidinii
Agric. Biol. Chem.
52
419-426
1988
2
-
-
-
-
-
10
-
-
1
-
-
-
1
-
-
-
-
-
-
1
-
15
-
1
-
-
-
2
-
1
4
-
-
-
2
-
-
4
-
-
-
-
10
-
-
-
1
-
-
-
-
-
-
-
-
1
-
15
-
1
-
-
-
2
-
1
-
-
-
-
-
-
-
285872
Leissing
Sorbitol dehydrogenase from ra ...
Ovis aries, Rattus norvegicus
Methods Enzymol.
89
135-140
1982
-
-
-
-
-
3
4
4
-
-
2
-
-
3
-
-
1
-
-
3
1
1
13
1
-
-
2
-
2
-
-
4
-
-
-
-
-
-
4
-
-
3
-
4
-
4
-
-
2
-
-
-
-
1
-
3
1
1
13
1
-
-
2
-
2
-
-
-
-
-
-
-
-
-
285873
Jeffery
Properties of sorbitol dehydro ...
Ovis aries
Eur. J. Biochem.
120
229-234
1981
-
-
-
-
-
3
6
-
-
-
1
-
-
3
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
4
-
-
3
-
6
-
-
-
-
1
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285883
Bailey
-
Sorbitol dehydrogenase from ho ...
Equus caballus, Ovis aries
Comp. Biochem. Physiol. B
69
909-914
1981
-
-
-
-
-
-
1
4
-
-
4
-
-
2
-
-
1
-
-
2
-
1
16
2
-
-
1
-
2
-
-
4
-
-
-
-
-
-
4
-
-
-
-
1
-
4
-
-
4
-
-
-
-
1
-
2
-
1
16
2
-
-
1
-
2
-
-
-
-
-
-
-
-
-
285900
Boguslawski
-
A method for the assay of gluc ...
Ovis aries
J. Appl. Biochem.
2
367-372
1980
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
6
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285874
Negm
Detection and characterization ...
Malus domestica
Plant Physiol.
64
69-73
1979
1
-
-
-
-
-
5
3
-
-
-
-
-
2
-
-
-
-
-
2
-
-
8
-
1
1
-
-
2
2
1
4
-
-
-
1
-
-
4
-
-
-
-
5
-
3
-
-
-
-
-
-
-
-
-
2
-
-
8
-
1
1
-
-
2
2
1
-
-
-
-
-
-
-
285875
Dooley
Kinetic determination of serum ...
Canis lupus familiaris, Homo sapiens, Mus musculus, Rattus norvegicus
Clin. Chem.
25
2026-2029
1979
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285876
Leissing
Rapid affinity purification an ...
Rattus norvegicus
Biochim. Biophys. Acta
524
254-261
1978
-
-
-
-
-
2
-
2
-
-
2
-
-
2
-
-
1
-
-
2
1
1
7
-
-
-
2
-
2
2
-
3
-
-
-
-
-
-
3
-
-
2
-
-
-
2
-
-
2
-
-
-
-
1
-
2
1
1
7
-
-
-
2
-
2
2
-
-
-
-
-
-
-
-
285879
Rehg
Partial purification and chara ...
Rattus norvegicus
J. Neurochem.
28
655-660
1977
2
-
-
-
-
1
5
9
-
-
-
1
-
2
-
-
1
-
-
2
-
1
10
-
-
-
-
-
2
2
-
4
-
-
-
2
-
-
4
-
-
1
-
5
-
9
-
-
-
1
-
-
-
1
-
2
-
1
10
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
285877
Gerlach
-
Sorbit-Dehydrogenase ...
Homo sapiens, Rattus norvegicus
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
1
601-606
1974
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
2
-
1
4
-
-
-
1
-
1
-
-
4
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
1
4
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
285878
Myers
Effect of polyhydric alcohols ...
Ovis aries
Biochem. Biophys. Res. Commun.
51
631-636
1973
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285880
Smith
Polyol dehydrogenase ...
Ovis aries
Biochem. J.
83
135-144
1962
-
-
-
1
-
-
6
4
-
-
1
-
-
1
-
-
1
-
-
1
1
-
6
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
2
1
-
-
-
6
-
4
-
-
1
-
-
-
-
1
-
1
1
-
6
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
285882
King
-
Sorbitol metabolism in spermat ...
Cavia porcellus, Ovis aries
Proc. R. Soc. Lond. B Biol. Sci.
151
226-243
1959
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
2
-
-
13
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
5
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285881
Williams-Ashman
Oxidation of polyhydric alcoho ...
Rattus norvegicus
Arch. Biochem. Biophys.
72
485-494
1957
-
-
-
-
-
-
4
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
5
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
3
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-