1.1.1.14: L-iditol 2-dehydrogenase

This is an abbreviated version, for detailed information about L-iditol 2-dehydrogenase, go to the full flat file.

Reaction

L-Iditol
+
NAD+
=
L-sorbose
+
NADH
+
H+

Synonyms

ADH, D-sorbitol dehydrogenase, dehydrogenase, L-iditol, Dgeo_2865, glucitol dehydrogenase, Hxt13, Hxt15, Hxt16, Hxt17, L-iditol 2-dehydrogenase, L-iditol dehydrogenase (sorbitol), L-iditol:NAD oxidoreductase, L-iditol:NAD+ 5-oxidoreductase, LeSDH, MdSDH5, More, NAD+-dependent sorbitol dehydrogenase, NAD-dependent polyol dehydrogenase, NAD-dependent sorbitol dehydrogenase, NAD-SDH, NAD-sorbitol dehydrogenase, PDH-11300, polyol dehydrogenase, Protein tms1, SDH, SldA, SLDH, Sor1, Sor2, sorbitol dehydrogenase, sorbitol transporter, SORD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.14 L-iditol 2-dehydrogenase

Activating Compound

Activating Compound on EC 1.1.1.14 - L-iditol 2-dehydrogenase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(R)-(-)-2-octanol
-
at pH 9.9
(S)-(+)-2-octanol
-
at pH 9.9
1-Hexanol
-
-
1-Octanol
-
-
2,2,2-tribromoethanol
-
-
2,2,2-trichloroethanol
-
-
2,2,2-Trifluoroethanol
-
-
2-monobromoethanol
-
-
2-monochloroethanol
-
-
2-monofluoroethanol
-
-
cysteine
-
fructose reduction at pH 7.4, inhibits at pH 9.0
D-sorbitol
-
at high concentration
dithiothreitol
-
1 mM 24% stimulation
haloalcohols
-
at high concentration
-
NaBr
-
-
NaCl
-
-
NaI
-
-
SDS
-
-
Semicarbazide
-
1 mM
Sodium azide
-
10 mM stimulates 2fold
sodium taurodeoxycholate
-
-
ZnSO4
additional information
-
enzyme needs product, i.e. SldB, of upstream gene sldB, encoding a hydrophobic polypeptide, for activity, the polypeptide might be a chaperone-like component that signals processing and folding of the enzyme to give the active enzyme form
-