BRENDA - Enzyme Database show
show all sequences of 1.1.1.14

Sorbitol dehydrogenase from Bacillus subtilis, purification, characterization and gene cloning

Ng, K.; Ye, R.; Wu, X.C.; Wong, S.L.; J. Biol. Chem. 267, 24989-24994 (1992)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
-
Bacillus subtilis
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
11
-
D-sorbitol
-
Bacillus subtilis
14
-
D-xylitol
-
Bacillus subtilis
18
-
L-Iditol
-
Bacillus subtilis
125
-
D-ribitol
-
Bacillus subtilis
500
-
D-galactitol
-
Bacillus subtilis
555
-
D-mannitol
-
Bacillus subtilis
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Zn
1 mol zinc per subunit
Bacillus subtilis
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
39000
-
4 * 39000, SDS-PAGE
Bacillus subtilis
153000
-
gel filtration
Bacillus subtilis
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bacillus subtilis
-
-
-
Purification (Commentary)
Commentary
Organism
-
Bacillus subtilis
Specific Activity [micromol/min/mg]
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
13.6
-
-
Bacillus subtilis
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-galactitol + NAD+
-
285887
Bacillus subtilis
D-tagatose + NADH
-
-
-
?
D-mannitol + NAD+
low activity
285887
Bacillus subtilis
?
-
-
-
?
D-ribitol + NAD+
-
285887
Bacillus subtilis
?
-
-
-
?
D-sorbitol + NAD+
-
285887
Bacillus subtilis
D-fructose + NADH + H+
-
-
-
?
D-xylitol + NAD+
-
285887
Bacillus subtilis
?
-
-
-
?
L-iditol + NAD+
-
285887
Bacillus subtilis
?
-
-
-
?
Subunits
Subunits
Commentary
Organism
tetramer
4 * 39000, SDS-PAGE
Bacillus subtilis
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Bacillus subtilis
NADH
-
Bacillus subtilis
Cloned(Commentary) (protein specific)
Commentary
Organism
-
Bacillus subtilis
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Bacillus subtilis
NADH
-
Bacillus subtilis
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
11
-
D-sorbitol
-
Bacillus subtilis
14
-
D-xylitol
-
Bacillus subtilis
18
-
L-Iditol
-
Bacillus subtilis
125
-
D-ribitol
-
Bacillus subtilis
500
-
D-galactitol
-
Bacillus subtilis
555
-
D-mannitol
-
Bacillus subtilis
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Zn
1 mol zinc per subunit
Bacillus subtilis
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
39000
-
4 * 39000, SDS-PAGE
Bacillus subtilis
153000
-
gel filtration
Bacillus subtilis
Purification (Commentary) (protein specific)
Commentary
Organism
-
Bacillus subtilis
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
13.6
-
-
Bacillus subtilis
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-galactitol + NAD+
-
285887
Bacillus subtilis
D-tagatose + NADH
-
-
-
?
D-mannitol + NAD+
low activity
285887
Bacillus subtilis
?
-
-
-
?
D-ribitol + NAD+
-
285887
Bacillus subtilis
?
-
-
-
?
D-sorbitol + NAD+
-
285887
Bacillus subtilis
D-fructose + NADH + H+
-
-
-
?
D-xylitol + NAD+
-
285887
Bacillus subtilis
?
-
-
-
?
L-iditol + NAD+
-
285887
Bacillus subtilis
?
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
tetramer
4 * 39000, SDS-PAGE
Bacillus subtilis
Other publictions for EC 1.1.1.14
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [░C]
Temperature Range [░C]
Temperature Stability [░C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [░C] (protein specific)
Temperature Range [░C] (protein specific)
Temperature Stability [░C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737257
Jordan
Hxt13, Hxt15, Hxt16 and Hxt17 ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508
Sci. Rep.
6
0000
2016
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2
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16
-
14
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16
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2
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16
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16
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-
736022
Wulf
Protein engineering of a therm ...
Deinococcus geothermalis, Deinococcus geothermalis DSM 11300
Enzyme Microb. Technol.
51
217-224
2012
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1
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2
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3
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5
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5
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11
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1
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2
4
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2
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1
2
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2
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3
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5
-
11
-
1
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2
4
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4
4
712908
Landau
Pharmacokinetics, pharmacodyna ...
Homo sapiens
J. Clin. Pharmacol.
50
521-530
2010
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1
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2
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1
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1
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1
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1
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1
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1
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1
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1
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1
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711357
Cao
Sorbitol can fuel mouse sperm ...
Mus musculus
Biol. Reprod.
80
124-133
2009
-
-
-
-
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-
-
-
1
-
1
1
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3
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4
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1
1
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1
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1
1
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4
-
-
1
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
712376
Lanaspa
ZAC1 is up-regulated by hypert ...
Homo sapiens, Mus musculus
J. Biol. Chem.
284
19974-19981
2009
-
-
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5
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8
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8
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2
2
2
2
-
-
712606
Wang
Ubiquitous distribution and di ...
Malus domestica
J. Exp. Bot.
60
1025-1034
2009
-
-
1
-
-
-
-
-
4
-
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-
5
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5
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2
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7
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8
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1
2
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-
-
687821
Krezel
Thionein/metallothionein contr ...
Ovis aries
J. Biol. Inorg. Chem.
13
401-409
2008
-
-
-
-
-
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-
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1
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1
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1
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1
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1
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-
689569
de Sousa
Sugar levels modulate sorbitol ...
Zea mays
Plant Mol. Biol.
68
203-213
2008
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2
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2
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2
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-
684974
Klimacek
Catalytic mechanism of Zn2+-de ...
Candida sp. HA 167, Ovis aries
Biochem. J.
404
421-429
2007
-
-
1
-
1
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-
6
-
2
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5
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3
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2
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3
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4
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1
4
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1
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6
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2
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3
-
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2
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3
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-
686021
Hellgren
A hydrogen-bonding network in ...
Rattus norvegicus
Cell. Mol. Life Sci.
64
3129-3138
2007
-
-
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1
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2
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4
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1
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3
4
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2
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1
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3
4
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2
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688074
Nosarzewski
Tissue-specific expression of ...
Malus domestica
J. Exp. Bot.
58
1863-1872
2007
-
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2
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4
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6
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4
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6
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688138
Duangsrisai
-
Presence and expression of NAD ...
Fragaria x ananassa
J. Hortic. Sci. Biotechnol.
82
191-198
2007
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1
1
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1
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3
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1
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1
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1
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1
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1
1
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3
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1
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1
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-
667062
Philippsen
Structure of zinc-independent ...
Rhodobacter sphaeroides
Acta Crystallogr. Sect. D
D61
374-379
2005
-
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1
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2
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668225
Marini
alpha-Crystallin: an ATP-indep ...
Bos taurus
Cell. Mol. Life Sci.
62
599-605
2005
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1
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3
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1
1
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1
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1
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1
1
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1
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668325
Karacaoglan
Steady-state kinetic propertie ...
Gallus gallus
Comp. Biochem. Physiol. B Biochem. Mol. Biol.
140
309-312
2005
-
-
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-
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2
4
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3
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2
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1
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2
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670513
Ohta
Molecular evidence of sorbitol ...
Solanum lycopersicum
Phytochemistry
66
2822-2828
2005
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1
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2
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1
1
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1
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7
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2
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655289
El-Kabbani
Sorbitol dehydrogenase: struct ...
Homo sapiens, Mammalia, Ovis aries, Rattus norvegicus
Curr. Med. Chem.
11
465-476
2004
2
2
-
2
-
-
25
10
4
4
8
4
-
4
-
-
-
4
-
7
-
-
12
6
-
-
-
7
-
1
-
4
19
-
-
2
2
-
4
2
-
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-
25
19
10
4
4
8
4
-
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-
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7
-
-
12
6
-
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7
-
1
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656930
Nosarszewski
-
Sorbitol dehydrogenase express ...
Malus domestica
Physiol. Plant.
121
391-398
2004
-
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1
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1
1
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3
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2
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2
1
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1
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1
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1
1
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1
1
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2
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2
1
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1
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654090
Darmanin
Expression, purification and p ...
Homo sapiens
Acta Crystallogr. Sect. D
59
558-560
2003
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1
1
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3
-
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1
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1
1
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1
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1
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1
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1
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1
-
1
1
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1
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1
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-
-
-
-
-
-
-
654867
Hoshino
Membrane-bound D-sorbitol dehy ...
Gluconobacter oxydans, Gluconobacter oxydans IFO 3255
Biochim. Biophys. Acta
1647
278-288
2003
1
1
1
-
1
-
-
-
1
-
1
2
-
7
-
-
-
-
-
-
-
-
6
2
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1
-
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1
1
1
-
-
1
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1
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1
2
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6
2
-
-
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-
1
-
-
-
-
-
-
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-
656694
Parmentier
-
Gluconobacter NAD-dependent po ...
Gluconobacter sp.
Meded. - Fac. Landbouwkd. Toegepaste Biol. Wet.
68
215-218
2003
-
-
-
-
-
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1
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2
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2
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1
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2
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2
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2
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2
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1
-
-
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-
-
657360
Pauly
X-ray crystallographic and kin ...
Homo sapiens
Structure
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2003
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1
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655022
Shinjoh
Main polyol dehydrogenase of G ...
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2002
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4
-
1
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1
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655030
Sugisawa
Purification and properties of ...
Gluconobacter oxydans, Gluconobacter oxydans IFO
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66
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2002
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1
8
1
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1
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14
1
1
1
4
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1
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1
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1
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8
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1
1
1
1
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1
-
14
1
1
1
4
-
1
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285898
Marini
Complete protection by alpha-c ...
Bos taurus
J. Biol. Chem.
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2000
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2
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1
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1
-
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4
-
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-
285899
Oura
Purification and characterizat ...
Pyrus pyrifolia
Phytochemistry
54
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2000
1
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4
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1
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8
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1
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8
-
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1
2
-
-
-
-
-
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680957
Shibata
Cloning of a gene for D-sorbit ...
Gluconobacter oxydans, Gluconobacter oxydans G624 (FERM BP-4415)
J. Biosci. Bioeng.
89
463-468
2000
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1
8
-
-
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2
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-
-
-
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285896
Takayuki
Purification and properties of ...
Bacillus megaterium
Biosci. Biotechnol. Biochem.
63
573-574
1999
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1
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4
2
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1
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1
-
1
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
285897
Adachi
Crystallization and properties ...
Gluconobacter oxydans, Gluconobacter oxydans IFO3257
Biosci. Biotechnol. Biochem.
63
1589-1595
1999
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-
-
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-
4
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1
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2
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1
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1
1
10
1
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2
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2
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1
2
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2
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4
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1
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1
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1
1
10
1
-
-
2
-
2
-
1
-
-
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-
-
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-
285895
Marini
Sorbitol dehydrogenase from bo ...
Bos taurus
Arch. Biochem. Biophys.
340
383-391
1997
-
-
-
-
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1
3
11
-
1
2
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1
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2
1
1
9
1
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2
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2
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2
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1
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3
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11
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1
2
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1
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2
1
1
9
1
-
-
-
-
2
-
-
-
-
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-
-
-
-
285892
Maret
Human sorbitol dehydrogenase - ...
Homo sapiens
Adv. Exp. Med. Biol.
383-393
1996
-
-
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5
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1
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9
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2
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2
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9
-
-
-
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1
-
-
-
-
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285893
Kvernmo
Reversible and irreversible in ...
Ovis aries
Int. J. Biochem. Cell Biol.
28
303-309
1996
-
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2
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-
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-
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-
285894
Lindstad
Reversible inhibition of sheep ...
Ovis aries
Eur. J. Biochem.
241
142-148
1996
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-
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1
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-
-
-
-
-
-
-
285890
Schauder
Polyol metabolism of Rhodobact ...
Rhodobacter sphaeroides, Rhodobacter sphaeroides Si4
Microbiology
141
1857-1863
1995
-
-
-
-
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2
2
6
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2
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5
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1
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1
1
16
1
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3
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2
2
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2
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2
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2
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2
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6
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2
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1
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1
1
16
1
-
-
3
-
2
2
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-
-
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-
285891
Lindstad
Effect of pH on sheep liver so ...
Ovis aries
Eur. J. Biochem.
233
891-898
1995
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-
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2
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2
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-
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2
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-
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-
285888
Yamaguchi
-
Purification and properties of ...
Malus domestica
Plant Cell Physiol.
35
887-892
1994
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4
2
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1
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8
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1
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8
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2
2
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285889
Lindstad
Inhibition and activation stud ...
Ovis aries
Eur. J. Biochem.
221
847-854
1994
15
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2
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1
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285887
Ng
Sorbitol dehydrogenase from Ba ...
Bacillus subtilis
J. Biol. Chem.
267
24989-24994
1992
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6
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6
1
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2
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1
2
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6
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2
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1
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1
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6
1
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-
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285886
Schneider
-
Sorbitol dehydrogenase from Ps ...
Pseudomonas sp.
Enzyme Microb. Technol.
13
332-337
1991
1
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1
10
6
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12
1
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5
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1
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2
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1
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10
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6
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2
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1
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1
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12
1
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5
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2
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285884
Rizzi
-
Purification and properties of ...
Scheffersomyces stipitis
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67
20-24
1989
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2
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1
1
9
1
1
1
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1
1
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2
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2
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3
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2
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2
1
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1
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1
1
9
1
1
1
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1
1
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285885
Rizzi
-
A kinetic study of the NAD+-xy ...
Scheffersomyces stipitis
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25-30
1989
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-
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285901
Vongsuvanlert
-
Characterization of D-sorbitol ...
Candida boidinii
Agric. Biol. Chem.
52
419-426
1988
2
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-
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10
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1
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1
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15
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1
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2
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1
4
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2
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4
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10
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1
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1
-
15
-
1
-
-
-
2
-
1
-
-
-
-
-
-
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285872
Leissing
Sorbitol dehydrogenase from ra ...
Ovis aries, Rattus norvegicus
Methods Enzymol.
89
135-140
1982
-
-
-
-
-
3
4
4
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2
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3
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1
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3
1
1
13
1
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2
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2
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4
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-
-
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4
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-
3
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4
-
4
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2
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-
1
-
3
1
1
13
1
-
-
2
-
2
-
-
-
-
-
-
-
-
-
285873
Jeffery
Properties of sorbitol dehydro ...
Ovis aries
Eur. J. Biochem.
120
229-234
1981
-
-
-
-
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3
6
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-
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1
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3
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1
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1
-
1
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4
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4
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3
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6
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1
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1
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1
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1
-
-
-
-
-
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-
-
-
-
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285883
Bailey
-
Sorbitol dehydrogenase from ho ...
Equus caballus, Ovis aries
Comp. Biochem. Physiol. B
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909-914
1981
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2
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4
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1
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2
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1
16
2
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1
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2
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285900
Boguslawski
-
A method for the assay of gluc ...
Ovis aries
J. Appl. Biochem.
2
367-372
1980
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6
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285874
Negm
Detection and characterization ...
Malus domestica
Plant Physiol.
64
69-73
1979
1
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3
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8
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1
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2
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1
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4
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2
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8
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1
1
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2
2
1
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285875
Dooley
Kinetic determination of serum ...
Canis lupus familiaris, Homo sapiens, Mus musculus, Rattus norvegicus
Clin. Chem.
25
2026-2029
1979
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8
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4
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8
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8
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4
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285876
Leissing
Rapid affinity purification an ...
Rattus norvegicus
Biochim. Biophys. Acta
524
254-261
1978
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2
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2
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2
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3
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2
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2
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1
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2
1
1
7
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2
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2
2
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285879
Rehg
Partial purification and chara ...
Rattus norvegicus
J. Neurochem.
28
655-660
1977
2
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9
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2
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10
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2
2
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4
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2
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4
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1
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5
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9
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1
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1
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2
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1
10
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2
2
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-
-
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-
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285877
Gerlach
-
Sorbit-Dehydrogenase ...
Homo sapiens, Rattus norvegicus
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
1
601-606
1974
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2
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2
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2
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1
4
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1
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1
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4
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4
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2
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2
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1
4
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1
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1
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Effect of polyhydric alcohols ...
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1973
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1
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285880
Smith
Polyol dehydrogenase ...
Ovis aries
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6
4
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6
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1
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6
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1
1
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6
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2
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285882
King
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Sorbitol metabolism in spermat ...
Cavia porcellus, Ovis aries
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1959
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13
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5
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5
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2
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13
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285881
Williams-Ashman
Oxidation of polyhydric alcoho ...
Rattus norvegicus
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485-494
1957
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