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Literature summary for 1.1.1.14 extracted from

  • Oura, Y.; Yamada, K.; Shiratake, K.; Yamaki, S.
    Purification and characterization of NAD+-dependent sorbitol dehydrogenase from Japanese pear fruit (2000), Phytochemistry, 54, 567-572.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ZnSO4 reverses cysteine inhibition Pyrus pyrifolia

Inhibitors

Inhibitors Comment Organism Structure
cysteine inhibits fructose reduction at pH 9.0, stimulates at pH 7.4 Pyrus pyrifolia
HgCl2
-
Pyrus pyrifolia
MgCl2
-
Pyrus pyrifolia
MnSO4
-
Pyrus pyrifolia

Organism

Organism UniProt Comment Textmining
Pyrus pyrifolia
-
japanese pear
-

Purification (Commentary)

Purification (Comment) Organism
-
Pyrus pyrifolia

Source Tissue

Source Tissue Comment Organism Textmining
fruit
-
Pyrus pyrifolia
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
55
-
-
Pyrus pyrifolia

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-ribitol + NAD+
-
Pyrus pyrifolia ?
-
?
D-sorbitol + NAD+
-
Pyrus pyrifolia D-fructose + NADH + H+
-
?
D-xylitol + NAD+
-
Pyrus pyrifolia ?
-
?
erythritol + NAD+ low activity Pyrus pyrifolia ?
-
?
ethanol + NAD+ low activity Pyrus pyrifolia acetaldehyde + NADH
-
?
L-arabitol + NAD+ low activity Pyrus pyrifolia ?
-
?
L-iditol + NAD+
-
Pyrus pyrifolia ?
-
?
L-threitol + NAD+
-
Pyrus pyrifolia ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
D-fructose reduction Pyrus pyrifolia

pH Range

pH Minimum pH Maximum Comment Organism
5 7.5 less than 20% of maximal activity below pH 5, less than 80% above pH 7.5, fructose reduction Pyrus pyrifolia
7.5 9 less than 20% of maximal activity below pH 7.5, 100% at pH 9.0, sorbitol oxidation Pyrus pyrifolia

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Pyrus pyrifolia
NADH
-
Pyrus pyrifolia