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Information on EC 2.7.11.21 - polo kinase and Organism(s) Homo sapiens and UniProt Accession Q9NYY3

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EC Tree
     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.11 Protein-serine/threonine kinases
                2.7.11.21 polo kinase
IUBMB Comments
The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein .
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Select one or more organisms in this record:
This record set is specific for:
Homo sapiens
UNIPROT: Q9NYY3
Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
Cdc5, Cdc5-polo kinase, Cdc5p, cell cycle protein kinase CDC5/MSD2, cytokine-inducible serine/threonine-protein kinase, FGF-inducible kinase, Fnk, for polo-like kinase 4, hPlk1, hPlk5, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
cytokine-inducible serine/threonine-protein kinase
265970
-
FGF-inducible kinase
-
-
-
-
hPlk1
247
-
hPlk5
247
-
HsPlk1
247
-
Plk-2
266022, 281798
-
PLK1 kinase
266022
-
Plk5
247
-
Polo kinase
247
-
polo-like kinase
Polo-like kinase 1
polo-like kinase 2
281798
-
polo-like kinase 3
polo-like kinase 4
polo-like kinase 5
247
-
polo-like kinase-1
polo-like kinase-2
polo-like-kinase 1
266022
-
Prk
265970
-
Proliferation-related kinase
-
-
-
-
serine/threonine-protein kinase PLK
266022
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + a protein = ADP + a phosphoprotein
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
phospho group transfer
PATHWAY SOURCE
PATHWAYS