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Literature summary for 2.7.11.21 extracted from

  • Wu, J.; Ivanov, A.I.; Fisher, P.B.; Fu, Z.
    Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling (2016), eLife, 5, e10734 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.21

Organism

Organism UniProt Comment Textmining
Homo sapiens P53350
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the active enzyme form is phosphorylated at tyrosine 210 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell
-
 Homo sapiens
-
LAPC-4 cell
-
 Homo sapiens
-
LNCaP cell
-
 Homo sapiens
-
LNCAP-C4-2B cell
-
 Homo sapiens
-
PC-3 cell
-
 Homo sapiens
-
prostate epithelium cell
-
 Homo sapiens
-
prostate gland cancer cell
-
 Homo sapiens
-
RWPE-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + CRAF protein
-
 Homo sapiens ADP + phosphorylated CRAF protein
-
 ?

Subunits

Subunits Comment Organism
? x * 60000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
Plk1
-
 Homo sapiens
Polo-like kinase 1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is downregulated in metastatic prostate cancer cells down

General Information

General Information Comment Organism
malfunction enzyme downregulation in metastatic prostate cancer cells enhances epithelial characteristics and inhibits cell motility Homo sapiens
physiological function the enzyme is a key regulator of epithelial-to-mesenchymal transition and cell motility in normal prostate epithelium and prostate cancer. The enzyme is a potent activator of MAPK signaling Homo sapiens