Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.21 extracted from

  • Pintard, L.; Archambault, V.
    A unified view of spatio-temporal control of mitotic entry Polo kinase as the key (2018), Open Biology, 8, 180114 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.21

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P53350
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme is activated by phosphorylation of Thr210 by protein phosphatase 1 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-
hTERT-RPE1 cell
-
 Homo sapiens
-
RKO cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Cdc25C
-
 Homo sapiens ADP + phosphorylated Cdc25C
-
 ?

Synonyms

Synonyms Comment Organism
Plk1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction complete inhibition of polo kinase 1 can prevent mitotic entry for hours in a vast majority of TERT-RPE1, HeLa or RKO cells, even without prior activation of the DNA damage checkpoint Homo sapiens
physiological function polo kinase 1 is essential for mitotic entry in human cells Homo sapiens