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Information on EC 2.7.11.21 - polo kinase

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EC Tree
     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.11 Protein-serine/threonine kinases
                2.7.11.21 polo kinase
IUBMB Comments
The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein .
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
Cdc5, Cdc5-polo kinase, Cdc5p, cell cycle protein kinase CDC5/MSD2, cytokine-inducible serine/threonine-protein kinase, FGF-inducible kinase, Fnk, for polo-like kinase 4, hPlk1, hPlk5, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + a protein = ADP + a phosphoprotein
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