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Literature summary for 2.7.11.21 extracted from

  • Liu, D.; Davydenko, O.; Lampson, M.A.
    Polo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing (2012), J. Cell Biol., 198, 491-499.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.21

Inhibitors

Inhibitors Comment Organism Structure
(R)-4-[(8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide i.e. BI2536 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
kinetochore the enzyme localizes to prometaphase kinetochores and is reduced at metaphase kinetochores Homo sapiens 776
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P53350
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
Plk1
-
 Homo sapiens
polo-like kinase-1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the dynamics of the enzyme at kinetochores control two critical mitotic processes: initially establishing correct kinetochore-microtubule attachments and subsequently silencing the spindle checkpoint Homo sapiens