Literature summary for 2.7.11.21 extracted from

Rodriguez-Nogales, C.; Garbayo, E.; Martinez-Valbuena, I.; Sebastian, V.; Luquin, M.R.; Blanco-Prieto, M.J.
Development and characterization of polo-like kinase 2 loaded nanoparticles - A novel strategy for (serine-129) phosphorylation of alpha-synuclein (2016), Int. J. Pharm., 514, 142-149 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in baculovirus-infected sf9 insect cells	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NYY3	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
SH-SY5Y cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + alpha-synuclein	the enzyme phosphorylates alpha-synuclein at Ser-129	Homo sapiens	ADP + phosphorylated alpha-synuclein	-	?
additional information	the enzyme can be successfully encapsulated in PLGA nanoparticles. The encapsulated enzyme remains bioactive and can phosphorylate intracellular alpha-synuclein at Ser-129 of SH-SY5Y cells	Homo sapiens	?	-	-

Subunits

Subunits	Comment	Organism
?	x * 105700, calculated from amino acid sequence	Homo sapiens
?	x * 106000, glutation-S-transferase tagged enzyme, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
Plk2	-	Homo sapiens
polo-like kinase 2	-	Homo sapiens

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Release 2023.1 (January 2023)