EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   2.7.11.21 | Adenocarcinoma |
18266952 |
RNA interference-mediated silencing of the polo-like kinase 1 gene enhances chemosensitivity to gemcitabine in pancreatic adenocarcinoma cells. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
1
4
4 |
| 2.7.11.21 | Adenocarcinoma |
22699824 |
A randomised phase II trial of the Polo-like kinase inhibitor BI 2536 in chemo-naïve patients with unresectable exocrine adenocarcinoma of the pancreas - a study within the Central European Society Anticancer Drug Research (CESAR) collaborative network. |
diagnostic usage
ongoing research
therapeutic application
unassigned |
3
1
4
0 |
| 2.7.11.21 | Adenocarcinoma |
26576650 |
FOXM1 and polo-like kinase 1 are co-ordinately overexpressed in patients with gastric adenocarcinomas. |
diagnostic usage
ongoing research
unassigned |
1
1
0 |
| 2.7.11.21 | Adenocarcinoma of Lung |
15694023 |
[Effect of antisense RNA targeting Polo-like kinase 1 on cell cycle of lung cancer cell line A549] |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
1
4
2 |
| 2.7.11.21 | Adrenal Cortex Neoplasms |
26754547 |
Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma. |
therapeutic application
unassigned |
4
0 |
| 2.7.11.21 | Adrenocortical Carcinoma |
26754547 |
Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma. |
therapeutic application
unassigned |
4
0 |
| 2.7.11.21 | Alzheimer Disease |
11124427 |
Neuronal polo-like kinase in Alzheimer disease indicates cell cycle changes. |
causal interaction
ongoing research
unassigned |
3
3
0 |
| 2.7.11.21 | Alzheimer Disease |
21931181 |
Inhibition of Polo-like kinase 1 reduces beta-amyloid-induced neuronal cell death in Alzheimer's disease. |
causal interaction
unassigned |
4
0 |
| 2.7.11.21 | Alzheimer Disease |
31306446 |
Inhibition of Polo-like kinase 2 ameliorates pathogenesis in Alzheimer's disease model mice. |
causal interaction
ongoing research
unassigned |
4
3
0 |
| 2.7.11.21 | Anemia, Aplastic |
27632389 |
Deregulation of vital mitotic kinase-phosphatase signaling in hematopoietic stem/progenitor compartment leads to cellular catastrophe in experimental aplastic anemia. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
