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Literature summary for 2.7.11.21 extracted from

  • Benoit, D.S.; Henry, S.M.; Shubin, A.D.; Hoffman, A.S.; Stayton, P.S.
    pH-responsive polymeric sirna carriers sensitize multidrug resistant ovarian cancer cells to doxorubicin via knockdown of polo-like kinase 1 (2010), Mol. Pharm., 7, 442-455.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine knockdown of plk1 results in sensitization of multidrug resistant cells to doxorubicin, and this combination of gene silencing and small drug delivery may prove useful to achieve potent therapeutic effects Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
siRNA
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P53350
-
-

Source Tissue

Source Tissue Comment Organism Textmining
NCI/ADR-RES cell
-
Homo sapiens
-
OVCAR-8 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
Plk1
-
Homo sapiens
Polo-like kinase 1
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens up-regulated in many cancers up

General Information

General Information Comment Organism
physiological function responsible for cell cycle progression Homo sapiens