Activating Compound | Comment | Organism | Structure |
---|---|---|---|
aurora A | - |
Homo sapiens | |
additional information | activation of Plk1 requires phosphorylation of the conserved threonine residue Thr210 | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | Plk1 is a promising therapeutic target for the treatmment of cancer | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[2-(trifluoromethyl)-benzyloxy]-thiophene-2-carboxamide | - |
Homo sapiens | |
BI2536 | - |
Homo sapiens | |
BI6727 | - |
Homo sapiens | |
GSK461364A | - |
Homo sapiens | |
HMN-214 | - |
Homo sapiens | |
LY294002 | - |
Homo sapiens | |
morin | - |
Homo sapiens | |
ON01910.Na | - |
Homo sapiens | |
quercetin | - |
Homo sapiens | |
SBE13 | - |
Homo sapiens | |
scytonemin | - |
Homo sapiens | |
siRNA | - |
Homo sapiens | |
Wortmannin | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
centrosome | - |
Homo sapiens | 5813 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast | - |
Homo sapiens | - |
colon | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
ovary | - |
Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
prostate | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Plk1 | - |
Homo sapiens |
polo-like kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00000005 | - |
less than 50 nM | Homo sapiens | GSK461364A | |
0.0000008 | - |
- |
Homo sapiens | BI2536 | |
0.00000087 | - |
- |
Homo sapiens | BI6727 | |
0.000024 | - |
- |
Homo sapiens | Wortmannin | |
0.00525 | - |
- |
Homo sapiens | LY294002 | |
0.0126 | - |
- |
Homo sapiens | morin | |
0.064 | - |
- |
Homo sapiens | quercetin |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | Plk1 is overexpressed in tumors | up |
General Information | Comment | Organism |
---|---|---|
physiological function | Plk1 is involved in the activation of Cdc2, chromosome segregation, centrosome maturation, bipolar spindle formation and execution of cytokinesis | Homo sapiens |