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Literature summary for 2.7.11.21 extracted from

  • Tamura, Y.; Simizu, S.; Muroi, M.; Takagi, S.; Kawatani, M.; Watanabe, N.; Osada, H.
    Polo-like kinase 1 phosphorylates and regulates Bcl-x(L) during pironetin-induced apoptosis (2009), Oncogene, 28, 107-116.
    View publication on PubMed
Search for more literature for 2.7.11.21

Activating Compound

Activating Compound Comment Organism Structure
okadaic acid
-
 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
human full-length Plk1 cDNA or FLAG-Plk1 cDNA is subcloned into the pZeoSV2+ vector Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
siRNA
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
centrosome
-
 Homo sapiens 5813
-
chromosome
-
 Homo sapiens 5694
-
spindle
-
 Homo sapiens 5819
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein Homo sapiens
-
 ADP + phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HT-1080 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Bcl-xL
-
 Homo sapiens ADP + phosphorylated Bcl-xL
-
 ?
ATP + protein
-
 Homo sapiens ADP + phosphoprotein
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 in vitro kinase assay Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 in vitro kinase assay Homo sapiens