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Literature summary for 2.7.11.21 extracted from

  • Lee, Y.; Lee, J.S.; Lee, K.J.; Turner, R.S.; Hoe, H.S.; Pak, D.T.S.
    Polo-like kinase 2 phosphorylation of amyloid precursor protein regulates activity-dependent amyloidogenic processing (2017), Neuropharmacology, 117, 387-400 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.21

Protein Variants

Protein Variants Comment Organism
K108M kinase-dead mutant Homo sapiens
T236E constitutively active mutant Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
BI2536
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NYY3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + amyloid precursor protein polo-like kinase 2 directly binds and phosphorylates threonine-668 and serine-675 of amyloid precursor protein in vitro Homo sapiens ADP + phosphorylated amyloid precursor protein
-
 ?

Synonyms

Synonyms Comment Organism
Plk2
-
 Homo sapiens
polo-like kinase 2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens picrotoxin strongly induces endogenous isoform Plk2 expression up

General Information

General Information Comment Organism
metabolism polo-like kinase 2 accelerates amyloid precursor protein amyloidogenic cleavage by beta-secretase at synapses and is required for neuronal overactivity-stimulated amyloid beta secretion Homo sapiens