3.5.2.2: dihydropyrimidinase
This is an abbreviated version!
For detailed information about dihydropyrimidinase, go to the full flat file.
Word Map on EC 3.5.2.2
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3.5.2.2
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5-fluorouracil
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thymidylate
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dihydropyridine
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colorectal
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fluoropyrimidine
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phosphorylase
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thymidine
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capecitabine
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l-type
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uracil
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nifedipine
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orotate
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resect
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blocker
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pharmacogenetic
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1,4-dihydropyridine
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tegafur
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prodrugs
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voltage-dependent
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dihydrouracil
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5-fu-based
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fluoropyrimidine-based
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nitrendipine
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leucovorin
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phosphoribosyltransferase
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diltiazem
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oxaliplatin
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irinotecan
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hemoperfusion
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phosphoribosyl
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5-fluorouracil-based
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mucositis
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neutropenia
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pyrrolizidine
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11-ketotestosterone
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excitation-contraction
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isradipine
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nisoldipine
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coniferyl
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5-fu-induced
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dihydropyridine-sensitive
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felodipine
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5\'-dfur
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dihydroorotase
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photochromic
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nicardipine
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synthesis
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industry
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5'-deoxy-5-fluorouridine
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pretherapeutic
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omega-conotoxin
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nutrition
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medicine
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hand-foot
- 3.5.2.2
- 5-fluorouracil
- thymidylate
-
dihydropyridine
- colorectal
-
fluoropyrimidine
- phosphorylase
- thymidine
- capecitabine
-
l-type
- uracil
- nifedipine
- orotate
-
resect
-
blocker
-
pharmacogenetic
-
1,4-dihydropyridine
-
tegafur
-
prodrugs
-
voltage-dependent
- dihydrouracil
-
5-fu-based
-
fluoropyrimidine-based
-
nitrendipine
- leucovorin
-
phosphoribosyltransferase
- diltiazem
- oxaliplatin
- irinotecan
-
hemoperfusion
-
phosphoribosyl
-
5-fluorouracil-based
- mucositis
- neutropenia
-
pyrrolizidine
- 11-ketotestosterone
-
excitation-contraction
- isradipine
- nisoldipine
-
coniferyl
-
5-fu-induced
-
dihydropyridine-sensitive
- felodipine
-
5\'-dfur
- dihydroorotase
-
photochromic
- nicardipine
- synthesis
- industry
- 5'-deoxy-5-fluorouridine
-
pretherapeutic
-
omega-conotoxin
- nutrition
- medicine
-
hand-foot
Reaction
Synonyms
4,5-dihydropyrimidine amidohydrolase, aaHYD, bar9HYD, bpHYD, bsHYD, CRMP, D-CpHPG, D-HYD, D-hydantionase, D-hydantoin-hydrolyzing enzyme, D-hydantoinase, D-PfHYD, DHP, DHP-1, DHP-2, DHPase, dht, DHTase, dihydropyrimidase/hydantoinase, Dihydropyrimidinase, dihydropyrimidine amidohydrolase, dihydropyrimidine dehydrogenase, HDT, HYD, hydantoin peptidase, hydantoinase, hydropyrimidine hydrase, hyuH, L-Hyd, L-hydantoinase, microbial hydantoinase, P479, PA0441, PaDHPase, PYD2, PydB, pyrimidine hydrase, SmelDhp, thHYD
ECTree
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Cloned
Cloned on EC 3.5.2.2 - dihydropyrimidinase
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a series of mutants of the enzyme with the C-terminal residues either deleted or substituted are prepared, expression in Escherichia coli
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cDNA sequences of dihydropyrimidinase determined
D-hydantoinase genes cloned and sequenced, Escherichia coli transformed with cosmid vectors, D-hydantoinase expressed and identified
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expressed in Escherichia coli
expressed in Escherichia coli BL21 (DE3) cells
expressed in Escherichia coli strain JM109, the expression level of dihydropyrimidinase in the recombinant Escherichia coli cells is estimated to be about 20% of the respective total soluble proteins
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expressed in Escherichia coli strains strains BL21 DE3 and JM109 (as a His-tagged enzyme)
expression in Escherichia coli
expression in Escherichia coli JM109
functional recombinant expression in Escherichia coli strain JM109
gene cloned and sequenced, identical with B. stearothermophilus NS1122A gene
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gene for thermostable hydantoinase cloned and overexpressed in Escherichia coli JM105, vector pAHN134
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gene hyd, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis and tree, recombinant expression of N-terminally His-tagged enzyme in Escherichia coli strain BL21(DE3)-pET28-hyd/pGRO7, mostly in insoluble form. Five sets of molecular chaperones are coexpressed with D-PfHYD in Escherichia coli, including pGRO7 (GroES-GroEL), pKJE7 (DnaK-DnaJ-GrpE), pTF16 (Tigger), pGRO7-KJE8 (GroES-GroEL & DnaK-DnaJ-GrpE), and pGRO7-TF2, to improve the method. Coexpression of the chaperone GroES-GroEL is most efficient in improving the soluble expression of D-PfHYD
gene pydB, recombinant expression of poly-His tagged enzyme in Escherichia coli
overexpression as His8-tagged fusion protein in Escherichia coli BL21
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overexpression of His6-tagged DHP in Escherichia coli Novablue cells
recombinant expression of His-tagged enzyme
recombinant expression of wild-type and mutant His-tagged enzymes