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3.5.2.2: dihydropyrimidinase

This is an abbreviated version!
For detailed information about dihydropyrimidinase, go to the full flat file.

Word Map on EC 3.5.2.2

Reaction

5,6-dihydrouracil
+
H2O
=
3-ureidopropanoate

Synonyms

4,5-dihydropyrimidine amidohydrolase, aaHYD, bar9HYD, bpHYD, bsHYD, CRMP, D-CpHPG, D-HYD, D-hydantionase, D-hydantoin-hydrolyzing enzyme, D-hydantoinase, D-PfHYD, DHP, DHP-1, DHP-2, DHPase, dht, DHTase, dihydropyrimidase/hydantoinase, Dihydropyrimidinase, dihydropyrimidine amidohydrolase, dihydropyrimidine dehydrogenase, HDT, HYD, hydantoin peptidase, hydantoinase, hydropyrimidine hydrase, hyuH, L-Hyd, L-hydantoinase, microbial hydantoinase, P479, PA0441, PaDHPase, PYD2, PydB, pyrimidine hydrase, SmelDhp, thHYD

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.2 In cyclic amides
                3.5.2.2 dihydropyrimidinase

Substrates Products

Substrates Products on EC 3.5.2.2 - dihydropyrimidinase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-methylhydantoin + H2O
3-methylhydantoic acid
show the reaction diagram
2-chlorobenzenehydantoin + H2O
?
show the reaction diagram
2-imidazolidone + H2O
?
show the reaction diagram
-
-
-
-
?
2-thiohydantoin + H2O
?
show the reaction diagram
-
-
-
-
?
2-thiouracil + H2O
?
show the reaction diagram
3-(4-nitrophenyl)-3-ureidopropanoic acid + H2O
?
show the reaction diagram
3-ethylphenylhydantoin + H2O
2-phenylhydantoic acid
show the reaction diagram
-
-
-
?
3-methylphenylhydantoin + H2O
2-phenylhydantoic acid
show the reaction diagram
-
-
-
?
3-phenylhydantoin + H2O
2-phenylhydantoic acid
show the reaction diagram
-
-
-
?
4-hydroxyphenylhydantoin + H2O
N-carbamoyl-D-hydroxyphenylglycine
show the reaction diagram
5,5-dimethylhydantoin + H2O
?
show the reaction diagram
-
-
-
-
?
5,6-dihydropyrimidine + H2O
beta-ureido acid
show the reaction diagram
5,6-dihydrothymine + H2O
3-(carbamoylamino)-2-methylpropanoic acid
show the reaction diagram
5,6-dihydrothymine + H2O
?
show the reaction diagram
5,6-dihydrothymine + H2O
N-carbamyl-beta-aminoisobutyrate
show the reaction diagram
5,6-dihydrouracil + H2O
3-ureidopropanoate
show the reaction diagram
5,6-dihydrouracil + H2O
3-ureidopropionate
show the reaction diagram
5,6-dihydrouracil + H2O
?
show the reaction diagram
5,6-dihydrouracil + H2O
N-carbamoyl-beta-alanine
show the reaction diagram
5,6-dihydrouracil + H2O
N-carbamyl-beta-alanine
show the reaction diagram
5-(2-thienyl)-DL-hydantoin + H2O
N-carbamoyl-D-2-thienylglycine
show the reaction diagram
-
-
-
-
?
5-(4-hydroxyphenyl) hydantoin + H2O
N-carbamoyl-D-4-hydroxyphenylglycine
show the reaction diagram
5-(4-hydroxyphenyl)hydantoin + H2O
5-(4-hydroxyphenyl)-D-carbamoylate
show the reaction diagram
-
-
-
-
?
5-(p-hydroxybenzyl)hydantoin + H2O
?
show the reaction diagram
5-bromo-5,6-dihydrouracil + H2O
?
show the reaction diagram
5-fluoro-5,6-dihydrouracil + H2O
?
show the reaction diagram
5-fluorouracil + H2O
2-fluoro-3-ureidopropionic acid
show the reaction diagram
5-fluorouracil + hydantoin
2-fluoro-3-ureidopropionic acid + ?
show the reaction diagram
5-hydroxymethylhydantoin + H2O
?
show the reaction diagram
-
-
-
-
?
5-iodo-5,6-dihydrouracil + H2O
?
show the reaction diagram
-
-
-
-
?
5-leucinyl-hydantoin + H2O
?
show the reaction diagram
5-phenylhydantoin + 2 H2O
D-phenylglycine + CO2 + NH3
show the reaction diagram
-
-
-
-
?
5-phenylhydantoin + H2O
5-phenyl D-carbamoylate
show the reaction diagram
-
-
-
-
?
5-propylhydantoin + H2O
N-carbamoyl-D-valine
show the reaction diagram
6-(4-nitrophenyl)dihydropyrimidine-2,4(1H,3H)-dione + H2O
?
show the reaction diagram
6-azauracil + H2O
?
show the reaction diagram
allantoin + H2O
?
show the reaction diagram
alpha-phenylsuccinimide + H2O
2-phenylsuccinamic acid
show the reaction diagram
beta-ureidoisobutyrate
dihydrothymine + H2O
show the reaction diagram
-
-
-
-
r
carbamoyl beta-aminoisobutyric acid + H2O
?
show the reaction diagram
D,L-benzylhydantoin + H2O
?
show the reaction diagram
D-2-phenylhydantoic acid + H2O
5-phenylhydantoin
show the reaction diagram
-
reverse reaction stereospecific, only D-isomer acts as substrate
-
-
r
D-5(p-hydroxybenzyl)-hydantoin + H2O
N-carbamoyl-D-tyrosine
show the reaction diagram
-
-
-
-
?
D-5-(1-methylpropyl)hydantoin + H2O
N-carbamoyl-D-isoleucine
show the reaction diagram
-
-
-
?
D-5-(2-methylthioethyl)hydantoin + H2O
N-carbamoyl-D-methionine
show the reaction diagram
D-5-benzylhydantoin + H2O
N-carbamoyl-D-phenylalanine
show the reaction diagram
D-5-butylhydantoin + H2O
?
show the reaction diagram
-
-
-
-
?
D-5-ethylhydantoin + H2O
?
show the reaction diagram
D-5-isobutylhydantoin + H2O
?
show the reaction diagram
-
-
-
-
?
D-5-isobutylhydantoin + H2O
N-carbamoyl-D-leucine
show the reaction diagram
D-5-isopropylhydantoin + H2O
?
show the reaction diagram
-
-
-
-
?
D-5-isopropylhydantoin + H2O
N-carbamoyl-D-valine
show the reaction diagram
D-5-methyl-thio-ethylhydantoin + H2O
?
show the reaction diagram
-
-
-
-
?
D-5-methylhydantoin + H2O
N-carbamoyl-D-alanine
show the reaction diagram
D-5-methylthioethylhydantoin + H2O
?
show the reaction diagram
D-5-propylhydantoin + H2O
?
show the reaction diagram
-
-
-
-
?
D-benzylhydantoin
D-N-carbamoylphenylalanine
show the reaction diagram
D-benzylhydantoin + H2O
D-N-carbamoylphenylalanine
show the reaction diagram
D-methylhydantoin + H2O
?
show the reaction diagram
dihydroorotic acid + H2O
?
show the reaction diagram
-
-
-
-
?
dihydropyrimidine + H2O
N-carbamoyl amino acid
show the reaction diagram
dihydrothymidine + H2O
?
show the reaction diagram
-
-
-
-
?
dihydrothymine + H2O
N-carbamoyl-beta-aminoisobutyric acid
show the reaction diagram
-
-
-
-
?
dihydrouracil + H2O
3-ureidopropionate
show the reaction diagram
dihydrouracil + H2O
N-carbamoyl-beta-alanine
show the reaction diagram
-
-
-
-
?
dihydrouracil + H2O
ureidopropionate
show the reaction diagram
dimethylhydantoin + H2O
?
show the reaction diagram
1.4% of the activity with dihydrouracil
-
-
?
DL-4-hydroxyphenylhydantoin + H2O
D-carbamoyl-4-hydroxyphenylglycine
show the reaction diagram
-
-
-
-
?
DL-5(2-(methylthio)-ethyl)hydantoin + H2O
?
show the reaction diagram
DL-5-(2-carboxyethyl)hydantoin + H2O
L-glutamic acid
show the reaction diagram
-
-
exclusively L-form
?
DL-5-(2-methylthioethyl)-hydantoin + H2O
N-carbamoyl-D-methionine
show the reaction diagram
DL-5-(p-hydroxyphenyl)hydantoin + H2O
N-carbamoyl-p-hydroxyphenylglycine
show the reaction diagram
DL-5-benzylhydantoin + H2O
?
show the reaction diagram
DL-5-butylhydantoin
?
show the reaction diagram
-
-
-
-
?
DL-5-carboxyethylhydantoin + H2O
?
show the reaction diagram
-
-
-
-
?
DL-5-cyanoethylhydantoin + H2O
?
show the reaction diagram
-
-
-
-
?
DL-5-indolylmethylhydantoin + H2O
L-tryptophan
show the reaction diagram
DL-5-isobutyl-hydantoin + H2O
?
show the reaction diagram
DL-5-isopropylhydantoin + H2O
N-carbamoyl-D-valine
show the reaction diagram
DL-5-methyldihydrouracil + H2O
?
show the reaction diagram
-
-
-
-
?
DL-5-methylhydantoin
?
show the reaction diagram
DL-5-p-hydroxyphenylhydantoin + H2O
D-p-hydroxyphenylglycine
show the reaction diagram
DL-5-phenylhydantoin + H2O
N-carbamoyl-D-phenylglycine
show the reaction diagram
DL-5-propylhydantoin
?
show the reaction diagram
-
-
-
-
?
DL-5-sec-butylhydantoin + H2O
?
show the reaction diagram
DL-5-thienylmethylhydantoin + H2O
?
show the reaction diagram
-
-
-
-
?
DL-6-(4-chlorophenyl)-5,6-dihydrouracil + H2O
4-chloro-N-carbamoyl-beta-phenylalanine
show the reaction diagram
DL-6-isopropyldihydrouracil + H2O
?
show the reaction diagram
-
-
-
-
?
DL-6-methyldihydrouracil + H2O
?
show the reaction diagram
-
-
-
-
?
DL-6-phenyl-5,6-dihydrouracil + H2O
N-rac-carbamoyl-beta-phenylalanine
show the reaction diagram
DL-fluorobromylhydantoin + H2O
?
show the reaction diagram
-
-
-
-
?
DL-homophenylalanylhydantoin + H2O
?
show the reaction diagram
DL-hydroxymethylhydantoin + H2O
?
show the reaction diagram
DL-hydroxyphenylhydantoin + H2O
?
show the reaction diagram
DL-hydroxyphenylhydantoin + H2O
N-carbamoyl-D-hydroxyphenylglycine
show the reaction diagram
DL-isoproylhydantoin + H2O
N-carbamoyl-D-valine
show the reaction diagram
DL-methylthioethylhydantoin + H2O
?
show the reaction diagram
-
D-selective for the hydrolysis
-
-
?
DL-p-hydroxyphenylhydantoin + H2O
?
show the reaction diagram
DL-p-hydroxyphenylhydantoin + H2O
N-carbamoyl-D-hydroxyphenylglycine
show the reaction diagram
DL-p-hydroxyphenylhydantoin + H2O
N-carbamoyl-D-p-hydroxyphenylglycine
show the reaction diagram
7.2% of the activity with dihydrouracil
-
-
?
DL-phenylhydantoin + H2O
N-carbamoyl-D-phenylglycine
show the reaction diagram
glutarimide + H2O
?
show the reaction diagram
hydantoin + H2O
?
show the reaction diagram
hydantoin + H2O
hydantoic acid
show the reaction diagram
hydantoin + H2O
N-carbamoyl glycine
show the reaction diagram
hydantoin + H2O
N-carbamoylglycine
show the reaction diagram
hydantoin + H2O
ureidoacetic acid
show the reaction diagram
-
-
-
-
?
hydrothymine
carbamoyl beta-aminoisobutyric acid
show the reaction diagram
-
-
-
?
hydrouracil + H2O
N-carbamoyl beta-alanine
show the reaction diagram
-
-
-
?
indolmethylhydantoin + H2O
tryptophan
show the reaction diagram
-
-
-
?
isobutylhydantoin + H2O
N-carbamoyl-D-alpha-isoleucine
show the reaction diagram
isopropylhydantoin + H2O
N-carbamoyl-D-valine
show the reaction diagram
-
-
-
?
L-5-(1-methylpropyl)hydantoin + H2O
N-carbamoyl-L-isoleucine
show the reaction diagram
-
-
-
?
L-5-(2-methylthioethyl)hydantoin + H2O
N-carbamoyl-L-methionine
show the reaction diagram
L-5-benzylhydantoin + H2O
N-carbamoyl-L-phenylalanine
show the reaction diagram
-
-
-
?
L-5-ethylhydantoin + H2O
?
show the reaction diagram
L-5-isobutylhydantoin + H2O
N-carbamoyl-L-leucine
show the reaction diagram
L-5-methylhydantoin + H2O
N-carbamoyl-L-alanine
show the reaction diagram
-
-
-
?
L-5-methylthioethylhydantoin + H2O
?
show the reaction diagram
L-benzylhydantoin
L-N-carbamoylphenylalanine
show the reaction diagram
m-chlorophenylhydantoin + H2O
?
show the reaction diagram
N-carbamoyl beta-alanine + H2O
5,6-dihydrouracil
show the reaction diagram
N-carbamoyl-beta-alanine + H2O
?
show the reaction diagram
N-carbamoyl-L-tryptophan + H2O
L-tryptophan + ?
show the reaction diagram
-
N-carbamoyl-D-tryptophan is no substrate
-
-
?
p-chlorophenylhydantoin + H2O
?
show the reaction diagram
p-methoxyphenylhydantoin + H2O
?
show the reaction diagram
-
-
-
-
?
p-methylphenylhydantoin + H2O
?
show the reaction diagram
-
-
-
-
?
phenylmethylhydantoin + H2O
phenylhydantoic acid
show the reaction diagram
-
-
-
?
phthalimide + H2O
?
show the reaction diagram
rac-5-p-fluorophenylhydantoin + H2O
?
show the reaction diagram
-
immobilized enzyme (linked to aminopropyl glass beads) converts 100%
-
-
?
rac-5-p-trifluoromethylphenylhydantoin + H2O
?
show the reaction diagram
-
immobilized enzyme (linked to aminopropyl glass beads) converts 87%
-
-
?
rac-5-phenylhydantoin + H2O
N-carbamoyl-D-phenylglycine
show the reaction diagram
-
immobilized enzyme (linked to aminopropyl glass beads) converts 100%
-
-
?
succinimide + H2O
?
show the reaction diagram
thymine + H2O
?
show the reaction diagram
-
-
-
-
?
uracil + H2O
?
show the reaction diagram
uric acid + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-