Reference on EC 3.5.2.2 - dihydropyrimidinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kim, G.J.; Kim, H.S.
Optimization of the enzymatic synthesis of D-p-hydroxyphenylglycine from DL-5-substituted hydantoin using D-hydantoinase and N-carbamoylase
Enzyme Microb. Technol.
17
63-67
1995
Agrobacterium tumefaciens, Agrobacterium sp., Agrobacterium sp. IP-I 671
-
Traut, T.W.; Loechel, S.
Pyrimidine catabolism: individual characterization of the three sequential enzymes with a new assay
Biochemistry
23
2533-2539
1984
Bos taurus, Canis lupus familiaris, Cavia porcellus, Oryctolagus cuniculus, Escherichia coli, Euglena gracilis, Mus musculus, Rattus norvegicus
Jacob, E.; Henco, K.; Marcinowski, S.; Schenk, G.
Cloning and sequencing of D-hydantoinase genes from thermophilic microorganisms, and transformation of mesophilic microorganisms with them
Biochem. Genet.
108
195
1988
Thermus sp.
-
Morin, A.; Hummel, W.; Kula, M.R.
Enrichment and selection of hydantoinase-producing micro-organisms
J. Gen. Microbiol.
133
1201-1207
1987
Pseudomonas fluorescens
-
Nishida, Y.; Nakamichi, K.; Nabe, K.; Tosa, T.
Enzymatic production of L-tryptophan from DL-5-indolylmethylhydantoin by Flavobacterium sp.
Enzyme Microb. Technol.
9
721-725
1987
Flavobacterium sp.
-
Lee, M.L.; Pettigrew, W.W.; Sander, E.G.; Nowak, T.
Bovine liver dihydropyrimidine amidohydrolase: pH dependencies of the steady-state kinetic and proton relaxation rate properties of the Mn(II)-containing enzyme
Arch. Biochem. Biophys.
259
597-604
1987
Bos taurus
Morin, A.; Hummel, W.; Schutte, H.; Kula, M.R.
Characterization of hydantoinase from Pseudomonas fluorescens strain DSM 84
Biotechnol. Appl. Biochem.
8
564-574
1986
Pseudomonas putida, Pseudomonas fluorescens
Morin, A.; Hummel, W.; Kula, M.R.
Production of hydantoinase from Pseudomonas fluorescens strain DSM 84
Appl. Microbiol. Biotechnol.
25
91-96
1986
Agrobacterium tumefaciens, Agrobacterium rhizogenes, Agrobacterium rubi, Agrobacterium sp., Pseudomonas putida, Pseudomonas fluorescens, Agrobacterium tumefaciens DSM 30147, Agrobacterium rubi DSM 30149, Agrobacterium rhizogenes DSM 30148, Agrobacterium tumefaciens DSM 30150, Agrobacterium sp. DSM 30201
-
Morin, A.; Hummel, W.; Kula, M.R.
Rapid detection of microbial hydantoinase on solid medium
Biotechnol. Lett.
8
573-576
1986
Agrobacterium tumefaciens, Agrobacterium rhizogenes, Agrobacterium rubi, Agrobacterium sp., no activity in Agrobacterium tumefaciens, no activity in Bacillus alcalophilus, no activity in Pseudomonas putida, Pseudomonas putida, Pseudomonas fluorescens, Agrobacterium tumefaciens DSM 30147, Agrobacterium rubi DSM 30149, no activity in Agrobacterium tumefaciens 30204, no activity in Pseudomonas putida DSM 1693, Agrobacterium rhizogenes DSM 30148, Agrobacterium tumefaciens DSM 30150, no activity in Pseudomonas putida DSM 549, Agrobacterium sp. DSM 30201
-
Lee, M.H.; Cowling, R.A.; Sander, E.G.; Pettigrew, D.W.
Bovine liver dihydropyrimidine amidohydrolase: pH dependencies of inactivation by chelators and steady-state kinetic properties
Arch. Biochem. Biophys.
248
368-378
1986
Bos taurus
Brooks, K.P.; Jones, E.A.; Kim, B.D.; Sander, E.G.
Bovine liver dihydropyrimidine amidohydrolase: Purification, properties, and characterization as a zinc metalloenzyme
Arch. Biochem. Biophys.
226
469-483
1983
Bos taurus
Takahashi, S.
Microbial synthesis of D-amino acids from DL-5-substituted hydantoins
Hakko Kogaku Kaishi
61
139-151
1983
Actinoplanes philippinensis, Enterobacter cloacae, Agrobacterium tumefaciens, Agrobacterium rhizogenes, Delftia acidovorans, Clavibacter michiganensis subsp. sepedonicus, Mycolicibacterium smegmatis, Gordonia rubripertincta, Pseudomonas putida, Pseudomonas chlororaphis, Streptomyces albus, Streptomyces griseus, Streptomyces mitakaensis
-
Shimizu, S.; Shimada, H.; Takahashi, S.; Ohashi, T.; Tani, Y.; Yamada, H.
Synthesis of N-carbamyl-D-2-thienylglycine and D-2-thienylglycine by microbial hydantoinase
Agric. Biol. Chem.
44
2233-2234
1980
Pseudomonas putida
-
Takahashi, S.; Ohashi, T.; Kii, Y.; Kumagai, H.; Yamada, H.
Microbial transformation of hydantoins to N-carbamyl-D-amino acids
J. Ferment. Technol.
57
328-332
1979
Enterobacter cloacae, Clavibacter michiganensis subsp. sepedonicus, Pseudomonas putida, Streptomyces griseus
-
Brooks, K.P.; Kim, B.D.; Sander, E.G.
Dihydropyrimidine amidohydrolase is a zinc metalloenzyme
Biochim. Biophys. Acta
570
213-214
1979
Bos taurus
Takahashi, S.; Kii, Y.; Kumagai, H.; Yamada, H.
Purification, crystallization and properties of hydantoinase from Pseudomonas striata
J. Ferment. Technol.
56
492-498
1978
Bos taurus, Pseudomonas putida
-
Cerere, F.; Galli, G.; Morisi, F.
Substrate and steric specificity of hydropyrimidine hydrase
FEBS Lett.
57
192-194
1975
Bos taurus, Rattus norvegicus
Mazs, B.; Buchowicz, J.
Activity of enzymes involved in pyrimidine metabolism in the germinating wheat grains
Phytochemistry
11
77-82
1972
Triticum aestivum
-
Wallach, D.P.; Grisolia, S.
The purification and properties of hydropyrimidine hydrase
J. Biol. Chem.
226
277-288
1956
Bos taurus, Columba sp., Rattus norvegicus
Dudley, K.H.; Buttler, T.C.; Bius, D.L.
The role of dihydropyrimidinase in the metabolism of some hydantoin and succinimide drugs
Drug Metab. Dispos.
2
103-112
1974
Bos taurus, Canis lupus familiaris, Cavia porcellus, Oryctolagus cuniculus, Felis catus, Platyrrhini, Mus musculus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Jacob, E.; Henco, K.; Marcinowski, S.; Schenk, G.
Verfahren zur Herstellung von mesophilen Mikroorganismen, die eine bei hherer Temperatur aktive D-Hydantoinase enthalten
(BASF A. -6) Ger. Offen. DE3535987 A1, (Cl. C12N15/00)
1-18
1987
Thermus sp.
-
Morin, A.; Leblanc, D.; Paleczek, A.; Hummel, W.; Kula, M.R.
Comparison of seven microbial D-hydantoinases
J. Biotechnol.
16
37-48
1990
Corynebacterium pseudodiphtheriticum, Pseudomonas putida, Pseudomonas fluorescens, Serratia liquefaciens, Serratia liquefaciens 1.15, Corynebacterium pseudodiphtheriticum 14.10
-
Runser, S.; Chinski, N.; Ohleyer, E.
D-p-Hydroxyphenylglycine production from DL-5-p-hydroxyphenylglycine production from DL-5-p-hydroxyphenylhydantoin by Agrobacterium sp.
Appl. Microbiol. Biotechnol.
33
382-388
1990
Agrobacterium tumefaciens, Agrobacterium sp., Arthrobacter crystallopoietes, Pseudomonas putida, Pseudomonas fluorescens, Agrobacterium sp. IP-I 671, Agrobacterium tumefaciens CIP 67.1
-
Jahnke, K.; Podschun, B.; Schnackerz, K.D.; Kautz, J.; Cook, P.F.
Acid-base catalytic mechanism of dihydropyrimidinase from pH studies
Biochemistry
32
5160-5166
1993
Bos taurus, Sus scrofa
Kikugawa, M.; Kaneko, M.; Fujimoto-Sakata, S.; Maeda, M.; Kawasaki, K.; Takagi, T.; Tamaki, N.
Purification, characterization and inhibition of dihydropyrimidinase from rat liver
Eur. J. Biochem.
219
393-399
1994
Bos taurus, Homo sapiens, Rattus norvegicus
Ishikawa, T.; Mukohara, Y.; Watabe, K.; Kobayashi, S.; Nakamura, H.
Microbial conversion of DL-5-substituted hydantoins to the corresponding L-amino acids by Bacillus stearothermophilus NS1122A
Biosci. Biotechnol. Biochem.
58
265-270
1994
Arthrobacter sp., Geobacillus stearothermophilus, Bos taurus, Flavobacterium sp., Pseudomonas sp., Pseudomonas putida, Pseudomonas fluorescens, Thermus sp., Pseudomonas sp. NS671, Arthrobacter sp. DSM 3747, Flavobacterium sp. AJ-3912
-
Mukohara, Y.; Ishikawa, T.; Watabe, K.; Nakamura, H.
A thermostable hydantoinase of Bacillus stearothermophilus NS1122A: Cloning, sequencing, and high expression of the enzyme gene, and some properties of the expressed enzyme
Biosci. Biotechnol. Biochem.
58
1621-1626
1994
Geobacillus stearothermophilus, Bos taurus, Pseudomonas sp., Pseudomonas putida, Pseudomonas sp. NS671
Durham, D.R.; Weber, J.E.
Properties of D-hydantoinase from Agrobacterium tumefaciens and its use for the preparation of N-carabmyl D-amino acids
Biochem. Biophys. Res. Commun.
216
1095-1100
1995
Agrobacterium tumefaciens, Agrobacterium sp., Agrobacterium sp. IP-I 671, Agrobacterium tumefaciens 47C
Luksa, V.; Starkuviene, V.; Starkuviene, B.; Dagys, R.
Purification and characterization of the D-hydantoinase from Bacillus circulans
Appl. Biochem. Biotechnol.
62
219-230
1997
Agrobacterium sp., Arthrobacter crystallopoietes, Geobacillus stearothermophilus, Brevibacillus brevis, Niallia circulans, Pseudomonas sp., Pseudomonas putida, Pseudomonas fluorescens, Agrobacterium sp. IP-I 671
Seung-Goo, L.; Dong-Cheol, L.; Hak-Sung, K.
Purification and characterization of thermostable D-hydantoinase from thermophilic Bacillus stearothermophilus SD-1
Appl. Biochem. Biotechnol.
62
251-266
1997
Agrobacterium sp., Geobacillus stearothermophilus, Bos taurus, Pseudomonas putida, Pseudomonas fluorescens, Rattus norvegicus, Thermus sp., Geobacillus stearothermophilus SD-1
May, O.; Siemann, M.; Pietzsch, M.; Kiess, M.; Mattes, R.; Syldatk, C.
Substrate-dependent enantioselectivity of a novel hydantoinase from Arthrobacter aurescens DSM 3745: Purification and characterization as new member of cyclic amidases
J. Biotechnol.
61
1-13
1998
Agrobacterium tumefaciens, Paenarthrobacter aurescens, Arthrobacter sp., Geobacillus stearothermophilus, Brevibacillus brevis, Bos taurus, Flavobacterium sp., Pseudomonas putida, Pseudomonas stutzeri, Rattus norvegicus, Geobacillus stearothermophilus JC2310, Arthrobacter sp. DSM 3747
Joo-Ho, P.; Geun-Joong, K.; Seun-Goo, L.; Dong-Cheol, L.; Hak-Sung, K.
Purification and characterization of thermostable D-hydantoinase from Bacillus thermocatenulatus GH-2
Appl. Biochem. Biotechnol.
81
53-64
1999
Agrobacterium sp., Geobacillus stearothermophilus, Geobacillus thermocatenulatus, Pseudomonas sp., Geobacillus stearothermophilus SD-1, Geobacillus thermocatenulatus GH-2
Sharma, R.; Vohra, R.M.
A thermostable D-hydantoinase isolated from a mesophilic Bacillus sp. AR9
Biochem. Biophys. Res. Commun.
234
485-488
1997
Agrobacterium tumefaciens, Agrobacterium sp., Geobacillus stearothermophilus, Bacillus sp. (in: Bacteria), Bos taurus, Peptococcus anaerobius, Pseudomonas sp., Pseudomonas putida, Geobacillus stearothermophilus SD-1, Bacillus sp. (in: Bacteria) AR9
Geun-Joong, K.; Hak-Sung, K.
C-terminal regions of D-hydantoinases are nonessential for catalysis, but affect the oligomeric structure
Biochem. Biophys. Res. Commun.
243
96-100
1998
Geobacillus stearothermophilus, Geobacillus thermocatenulatus, Homo sapiens, Pseudomonas putida, Rattus norvegicus, Geobacillus stearothermophilus SD-1, Geobacillus thermocatenulatus GH-2
Siemann, M.; Alvarado-Marin, A.; Pietzsch, M.; Syldatk, C.
A D-specific hydantoin amidohydrolase: properties of the metalloenzyme purified from Arthrobacter crystallopoietes
J. Mol. Catal. , B Enzym.
6
387-397
1999
Agrobacterium tumefaciens, Agrobacterium sp., Paenarthrobacter aurescens, Arthrobacter crystallopoietes, Geobacillus stearothermophilus, Bacillus sp. (in: Bacteria), Parageobacillus thermoglucosidasius, Homo sapiens, Pseudomonas sp., Pseudomonas putida, Pseudomonas fluorescens, Rattus norvegicus, Agrobacterium sp. IP-I 671, Pseudomonas sp. AJ-11220, Bacillus sp. (in: Bacteria) LU 1220
-
Abendroth, J.; Niefind, K.; Chatterjee, S.; Schomburg, D.
Crystallization, preliminary X-ray analysis of a native and selenomethionine D-hydantoinase from Thermus sp.
Acta Crystallogr. Sect. D
56
1166-1169
2000
Thermus sp.
Geun-Joong, K.; Dong-Eun, L.; Hak-Sung, K.
Construction and evaluation of a novel bifunctional N-carbamylase-D-hydantoinase fusion enzyme
Appl. Environ. Microbiol.
66
2133-2138
2000
Agrobacterium tumefaciens, Agrobacterium sp., Geobacillus stearothermophilus, Geobacillus thermocatenulatus, Escherichia coli, Homo sapiens, Pseudomonas putida, Agrobacterium sp. IP-I 671, Agrobacterium tumefaciens DSM 30147, Geobacillus stearothermophilus SD-1, Geobacillus thermocatenulatus GH-2
Abendroth, J.; Chatterjee, S.; Schomburg, D.
Purification of a D-hydantoinase using a laboratory-scale streamline phenyl column as the initial step
J. Chromatogr.
737
187-194
2000
Thermus sp.
Agrawal, V.; Sharma, R.; Vohra, R.M.; Kishan, K.V.
Crystallization and preliminary X-ray diffraction analysis of a thermostable D-hydantoinase from the mesophilic Bacillus sp. AR9
Acta Crystallogr. Sect. D
58
2175-2176
2002
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) AR9
Huang, C.Y.; Chiang, S.K.; Yang, Y.S.; Sun, Y.J.
Crystallization and preliminary X-ray diffraction analysis of thermophilic imidase from pig liver
Acta Crystallogr. Sect. D
D59
943-945
2003
Sus scrofa
Abendroth, J.; Niefind, K.; May, O.; Siemann, M.; Syldatk, C.; Schomburg, D.
The structure of L-hydantoinase from Arthobacter aurescens leads to an understanding of dihydropyrimidinase substrate and enantio specificity
Biochemistry
41
8589-8597
2002
Paenarthrobacter aurescens (P81006), Paenarthrobacter aurescens
Cheon, Y.H.; Park, H.S.; Kim, J.H.; Kim, Y.; Kim, H.S.
Manipulation of the active site loops of D-hydantoinase, a (beta/alpha)8-barrel protein, for modulation of the substrate specificity
Biochemistry
43
7413-7420
2004
Geobacillus stearothermophilus, Geobacillus stearothermophilus SD1
Clemente-Jimenez, J.M.; Martinez-Rogriguez, S.; Mingorance-Cazorla, L.; de la Escalera-Hueso, S.; las Heras-Vazquez, F.J.; Rodriguez-Vico, F.
Catalytic analysis of a recombinant D-hydantoinase from Agrobacterium tumefaciens
Biotechnol. Lett.
25
1067-1073
2003
Agrobacterium tumefaciens, Agrobacterium tumefaciens BQL9
Xu, Z.; Liu, Y.; Yang, Y.; Jiang, W.; Arnold, E.; Ding, J.
Crystal structure of D-hydantoinase from Burkholderia pickettii at a resolution of 2.7 Angstroms: insights into the molecular basis of enzyme thermostability
J. Bacteriol.
185
4038-4049
2003
Ralstonia pickettii
Arcuri, M.B.; Sabino, S.J.; Antunes, O.A.C.; Oestreicher, E.G.
On the mechanism of hydrolysis of hydantoins by D-hydantoinase from Vigna angularis: inhibition studies
J. Mol. Catal. B
21
107-111
2003
Vigna angularis
-
Huang, C.Y.; Chao, Y.P.; Yang, Y.S.
Purification of industrial hydantoinase in one chromatographic step without affinity tag
Protein Expr. Purif.
30
134-139
2003
Agrobacterium tumefaciens, Agrobacterium tumefaciens NRRL B11291
Ikemi, M.
Industrial chemicals: enzymic transformation by recombinant microbes
Bioprocess Technol.
19
797-813
1994
Brevibacillus brevis
Dobritzsch, D.; Andersen, B.; Piskur, J.
Crystallization and X-ray diffraction analysis of dihydropyrimidinase from Saccharomyces kluyveri
Acta Crystallogr. Sect. F
61
359-362
2005
Lachancea kluyveri
Lohkamp, B.; Andersen, B.; Piskur, J.; Dobritzsch, D.
Purification, crystallization and X-ray diffraction analysis of dihydropyrimidinase from Dictyostelium discoideum
Acta Crystallogr. Sect. F
62
36-38
2005
Dictyostelium discoideum
Arcuri, M.B.; Antunes, O.A.; Machado, S.P.; Almeida, C.H.; Oestreicher, E.G.
Stability of immobilized D-hydantoinase from Vigna angularis and repeated cycles of highly enantioenriched production of N-carbamoyl-D-phenylglycines
Amino Acids
27
69-74
2004
Vigna angularis
Lin, L.L.; Hsu, W.H.; Hsu, W.Y.; Kan, S.C.; Hu, H.Y.
Phylogenetic analysis and biochemical characterization of a thermostable dihydropyrimidinase from alkaliphilic Bacillus sp. TS-23
Antonie van Leeuwenhoek
88
189-197
2005
Thermus sp., Streptomyces coelicolor (O69809), Agrobacterium tumefaciens (Q44184), Geobacillus stearothermophilus (Q45515), Geobacillus stearothermophilus, Bacillus sp. (in: Bacteria) (Q56S49), Bacillus sp. (in: Bacteria), Pseudomonas putida (Q59699), Ralstonia pickettii (Q8VTT5), Bacillus sp. (in: Bacteria) TS-23 (Q56S49)
Matcher, G.F.; Burton, S.G.; Dorrington, R.A.
Mutational analysis of the hydantoin hydrolysis pathway in Pseudomonas putida RU-KM3S
Appl. Microbiol. Biotechnol.
65
391-400
2004
Pseudomonas putida (Q59699), Pseudomonas putida, Pseudomonas putida RU-KM3S (Q59699)
Suzuki, S.; Takenaka, Y.; Onishi, N.; Yokozeki, K.
Molecular cloning and expression of the hyu genes from Microbacterium liquefaciens AJ 3912, responsible for the conversion of 5-substituted hydantoins to alpha-amino acids, in Escherichia coli
Biosci. Biotechnol. Biochem.
69
1473-1482
2005
Microbacterium liquefaciens, Paenarthrobacter aurescens (P81006), Microbacterium liquefaciens AJ3912
Shi, Y; Zhao, L.; Niu, L.; Feng, X.; Yuan, J.
Gene sequence, soluble expression and homologous comparison of a D-hydantoinase from Pseudomonas putida YZ-26
Chem. Res. Chin. Univ.
21
552-557
2005
Pseudomonas putida (Q6TTR0), Pseudomonas putida YZ-26 (Q6TTR0)
-
Werner, M.; Vasquez, F.J.; Fritz, C.; Vielhauer, O.; Siemann-Herzberg, M.; Altenbucher, J.; Syldatk, C.
Cloning of D-specific hydantoin utilization genes from Arthrobacter crystallopoietes
Eng. Life Sci.
4
563-572
2004
Geobacillus stearothermophilus (Q45515), Arthrobacter crystallopoietes (Q84FR6), Arthrobacter crystallopoietes DSM 20117 (Q84FR6)
-
Wu, S.; Yang, L.; Liu, Y.; Zhao, G.; Wang, J.; Sun, W.
Enzymatic production of D-p-hydroxyphenylglycine from DL-5-hydroxyphenylhydantoin by Sinorhizobium morelense S-5
Enzyme Microb. Technol.
36
520-526
2005
Ensifer adhaerens, Ensifer adhaerens S-5
-
Rawls, J.M.
Analysis of pyrimidine catabolism in Drosophila melanogaster using epistatic interactions with mutations of pyrimidine biosynthesis and beta-alanine metabolism
Genetics
172
1665-1674
2006
Caenorhabditis elegans (Q18677), Caenorhabditis elegans (Q21773), Drosophila melanogaster (Q2XST3), Drosophila melanogaster (Q8IPQ2), Drosophila melanogaster, Dictyostelium discoideum (Q55DL0), Mus musculus (Q9EQF5), Arabidopsis thaliana (Q9FMP3), Pseudomonas aeruginosa (Q9I676), Lachancea kluyveri (Q9P903), Drosophila melanogaster EP(3)3238 (Q2XST3), Drosophila melanogaster EP(3)3238 (Q8IPQ2)
Lohkamp, B.; Andersen, B.; Piskur, J.; Dobritzsch, D.
The crystal structures of dihydropyrimidinases reaffirm the close relationship between cyclic amidohydrolases and explain their substrate specificity
J. Biol. Chem.
281
13762-13776
2006
Dictyostelium discoideum (Q55DL0), Dictyostelium discoideum, Lachancea kluyveri (Q9P903), Lachancea kluyveri
Huang, J.H.; Hsu, W.H.; Chen, C.W
Effects of culturing conditions on production of D-hydantoinase from Escherichia coli
J. Microbiol. Immunol. Infect.
37
313-321
2004
Agrobacterium tumefaciens, Agrobacterium tumefaciens DUL-DH101
Radha Kishan, K.V.; Vohra, R.M.; Ganesan, K.; Agrawal, V.; Sharma, V.M.; Sharma, R.
Molecular structure of D-hydantoinase from Bacillus sp. AR9: evidence for mercury inhibition
J. Mol. Biol.
347
95-105
2005
Paenarthrobacter aurescens, Geobacillus stearothermophilus, Bacillus sp. (in: Bacteria), Ralstonia pickettii, Thermus sp., Bacillus sp. (in: Bacteria) AR9
Li, J.; Li, S.; Yan, M.; Yao, Z.; Ouyang, P.
Purification and biochemical characterization of D-hydantoinase and D-N-carbamoylase from Burkholderia cepacia.njut01
J. Shanghai Univers.
9
176-183
2005
Burkholderia cepacia, Burkholderia cepacia njut01
-
Chen, H.Y.; Tsai, H.
Cloning, sequencing, and expression in Escherichia coli of D-hydantoinase gene from Pseudomonas putida
Ann. N. Y. Acad. Sci.
864
234-237
1998
Pseudomonas putida, Pseudomonas putida 7711-2
West, T.P.
Pyrimidine base catabolism in Pseudomonas putida biotype B
Antonie van Leeuwenhoek
80
163-167
2001
Pseudomonas putida
Chien, H.R.; Jih, Y.L.; Yang, W.Y.; Hsu, W.H.
Identification of the open reading frame for the Pseudomonas putida D-hydantoinase gene and expression of the gene in Escherichia coli
Biochim. Biophys. Acta
1395
68-77
1998
Pseudomonas putida (Q59699), Pseudomonas putida, Pseudomonas putida CCRC 12857 / ATCC 950 (Q59699)
Martinez-Rodriguez, S.; Gonzalez-Ramirez, L.A.; Clemente-Jimenez, J.M.; Rodriguez-Vico, F.; Las Heras-Vazquez, F.J.; Gavira, J.A.; Garcia-Ruiz, J.M.
Crystallization and preliminary crystallographic studies of the recombinant dihydropyrimidinase from Sinorhizobium meliloti CECT4114
Acta Crystallogr. Sect. F
62
1223-1226
2006
Sinorhizobium meliloti (Q0PQZ5), Sinorhizobium meliloti CECT4114 (Q0PQZ5), Sinorhizobium meliloti CECT4114
Zhang, X.; Niu, L.; Shi, Y.; Yuan, J.
The flexibility of the non-conservative region at the C terminus of D-hydantoinase from Pseudomonas putida YZ-26 is extremely limited
Appl. Biochem. Biotechnol.
144
237-247
2008
Pseudomonas putida, Pseudomonas putida YZ-26
Schnackerz, K.D.; Dobritzsch, D.
Amidohydrolases of the reductive pyrimidine catabolic pathway: Purification, characterization, structure, reaction mechanisms and enzyme deficiency
Biochim. Biophys. Acta
1784
431-444
2008
Bos taurus, Dictyostelium discoideum, Homo sapiens, Lachancea kluyveri, Rattus norvegicus
Niu, L.; Zhang, X.; Shi, Y.; Yuan, J.
Subunit dissociation and stability alteration of D-hydantoinase deleted at the terminal amino acid residue
Biotechnol. Lett.
29
303-308
2007
Pseudomonas putida (Q6TTR0), Pseudomonas putida YZ-26 (Q6TTR0)
Bulawayo, B.T.; Dorrington, R.A.; Burton, S.G.
Enhanced operational parameters for amino acid production using hydantoin-hydrolysing enzymes of Pseudomonas putida strain RUKM3s immobilised in Eupergit C
Enzyme Microb. Technol.
40
533-539
2007
Pseudomonas putida, Pseudomonas putida RUKM3s
-
Kirchmann, S.; van Zyl, P.; Brady, D.; Abrahams, N.; Rech, S.; Dorrington, R.; Burton, S.
A dual phase fermentation protocol for the production of hydantoinase and carbamoylase by the wild type Pseudomonas putida RU-KM3
Enzyme Microb. Technol.
41
539-545
2007
Pseudomonas putida, Pseudomonas putida RU-KM3
-
Annamalai, M.; Doble, M.
Modeling of D-hydantionase production by Agrobacterium radiobacter in a batch system
J. Appl. Sci.
7
2051-2056
2007
Agrobacterium tumefaciens, Agrobacterium tumefaciens NRRL B-11291
-
Andujar-Sanchez, M.; Las Heras-Vazquez, F.J.; Clemente-Jimenez, J.M.; Martinez-Rodriguez, S.; Camara-Artigas, A.; Rodriguez-Vico, F.; Jara-Perez, V.
Enzymatic activity assay of D-hydantoinase by isothermal titration calorimetry. Determination of the thermodynamic activation parameters for the hydrolysis of several substrates
J. Biochem. Biophys. Methods
67
57-66
2006
Agrobacterium tumefaciens, Agrobacterium tumefaciens BQL9
Kao, C.H.; Lo, H.H.; Hsu, S.K.; Hsu, W.H.
A novel hydantoinase process using recombinant Escherichia coli cells with dihydropyrimidinase and L-N-carbamoylase activities as biocatalyst for the production of L-homophenylalanine
J. Biotechnol.
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2008
Brevibacillus agri, Brevibacillus agri NCHU1002
Tewari, Y.B.; Kishore, N.; Lang, B.E.; Goldberg, R.N.
Thermodynamics of reactions catalyzed by D-hydantoinase and N-carbamoyl-D-amino acid hydrolase
J. Chem. Thermodyn.
39
717-728
2007
Pseudomonas putida
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Duerr, R.; Vielhauer, O.; Burton, S.G.; Cowan, D.A.; Punal, A.; Brandao, P.F.; Bull, A.T.; Syldatk, C.
Distribution of hydantoinase activity in bacterial isolates from geographically distinct environmental sources
J. Mol. Catal. B
39
160-165
2006
Acinetobacter sp., Arthrobacter sp., Bacillus sp. (in: Bacteria), Burkholderia sp., Enterobacter sp., Flavobacterium sp., Pseudomonas sp., Staphylococcus sp., Delftia tsuruhatensis, Ochrobactrum sp., Stenotrophomonas sp.
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Jia, H.; Ni, F.; Chen, M.; Zhou, H.; Wei, P.; Ouyang, P.
The immobilization of D-hydantoinase and characterization under classic condition and microwave irradiation
J. Mol. Catal. B
43
74-79
2006
Burkholderia cepacia, Burkholderia cepacia JS-02
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van Kuilenburg, A.B.; Meijer, J.; Dobritzsch, D.; Meinsma, R.; Duran, M.; Lohkamp, B.; Zoetekouw, L.; Abeling, N.G.; van Tinteren, H.L.; Bosch, A.M.
Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency
Mol. Genet. Metab.
91
157-164
2007
Homo sapiens
van Kuilenburg, A.B.; van Lenthe, H.; van Gennip, A.H.
Activity of pyrimidine degradation enzymes in normal tissues
Nucleosides Nucleotides Nucleic Acids
25
1211-1214
2006
Homo sapiens
Thomas, H.R.; Ezzeldin, H.H.; Guarcello, V.; Mattison, L.K.; Fridley, B.L.; Diasio, R.B.
Genetic regulation of beta-ureidopropionase and its possible implication in altered uracil catabolism
Pharmacogenet. Genomics
18
25-35
2008
Homo sapiens
Chiang, C.J.; Chen, H.C.; Chao, Y.P.; Tzen, J.T.
One-step purification of insoluble hydantoinase overproduced in Escherichia coli
Protein Expr. Purif.
52
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2007
Agrobacterium tumefaciens, Agrobacterium tumefaciens NRRL B-11291
Shi, Y.; Niu, L.; Feng, X.; Yuan, J.
Purification, enzymatic properties of a recombinant D-hydantoinase and its dissociation by zinc ion
World J. Microbiol. Biotechnol.
22
675-680
2006
Pseudomonas putida (Q6TTR0), Pseudomonas putida YZ-26 (Q6TTR0)
Martinez-Rodriguez, S.; Encinar, J.A.; Hurtado-Gomez, E.; Prieto, J.; Clemente-Jimenez, J.M.; Las Heras-Vazquez, F.J.; Rodriguez-Vico, F.; Neira, J.L.
Metal-triggered changes in the stability and secondary structure of a tetrameric dihydropyrimidinase: a biophysical characterization
Biophys. Chem.
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Sinorhizobium meliloti
Zrenner, R.; Riegler, H.; Marquard, C.R.; Lange, P.R.; Geserick, C.; Bartosz, C.E.; Chen, C.T.; Slocum, R.D.
A functional analysis of the pyrimidine catabolic pathway in Arabidopsis
New Phytol.
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Arabidopsis thaliana
Jiwaji, M.; Dorrington, R.A.
Regulation of hydantoin-hydrolyzing enzyme expression in Agrobacterium tumefaciens strain RU-AE01
Appl. Microbiol. Biotechnol.
84
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2009
Agrobacterium tumefaciens
Zhang, X.; Yuan, J.; Niu, L.; Liang, A.
Quantitative analysis and functional evaluation of zinc ion in the D-hydantoinase from Pseudomonas putida YZ-26
Biometals
23
71-81
2010
Pseudomonas putida
Lee, S.; Chang, Y.; Shin, D.; Han, J.; Seo, M.; Fazelinia, H.; Maranas, C.; Kim, H.
Designing the substrate specificity of D-hydantoinase using a rational approach
Enzyme Microb. Technol.
44
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Geobacillus stearothermophilus (Q45515)
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Cai, Y.; Trodler, P.; Jiang, S.; Zhang, W.; Wu, Y.; Lu, Y.; Yang, S.; Jiang, W.
Isolation and molecular characterization of a novel D-hydantoinase from Jannaschia sp. CCS1
FEBS J.
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Jannaschia sp. CCS1 (Q28SA7)
Mei, Y.Z.; Wan, Y.M.; He, B.F.; Ying, H.J.; Ouyang, P.K.
New gene cluster from the thermophile Bacillus fordii MH602 in the conversion of DL-5-substituted hydantoins to L-amino acids
J. Microbiol. Biotechnol.
19
1497-1505
2009
Siminovitchia fordii (A1E351), Siminovitchia fordii
Aranaz, I.; Acosta, N.; Heras, A.
Encapsulation of an Agrobacterium radiobacter extract containing D-hydantoinase and D-carbamoylase activities into alginate-chitosan polyelectrolyte complexes. Preparation of the biocatalyst
J. Mol. Catal. B
58
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2009
Agrobacterium tumefaciens
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Martinez-Rodriguez, S.; Martinez-Gomez, A.I.; Clemente-Jimenez, J.M.; Rodriguez-Vico, F.; Garcia-Ruiz, J.M.; Las Heras-Vazquez, F.J.; Gavira, J.A.
Structure of dihydropyrimidinase from Sinorhizobium meliloti CECT4114: new features in an amidohydrolase family member
J. Struct. Biol.
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Sinorhizobium meliloti
Engel, U.; Syldatk, C.; Rudat, J.
Stereoselective hydrolysis of aryl-substituted dihydropyrimidines by hydantoinases
Appl. Microbiol. Biotechnol.
94
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2011
Arthrobacter crystallopoietes, Ochrobactrum sp. G21, Delftia sp. I24, Ochrobactrum sp. G21 DSM 18828, Arthrobacter crystallopoietes DSM 20117, Delftia sp. I24 DSM 18833
Ko, Y.; Chen, C.; Shieh, C.; Liu, Y.
Simultaneous purification and immobilization of D-hydantoinase on the immobilized metal affinity membrane via coordination bonds
Biochem. Eng. J.
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2012
Brevibacillus agri (Q846U5), Brevibacillus agri NCHU1002 (Q846U5)
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cheon, Y.-H.; Kim, H.-S.; Han, K.-H.; Abendroth, J.; Niefind, K.; Schomburg, D.; Wang, J.; Kim, Y.
Crystal structure of D-hydantoinase from Bacillus stearothermophilus: insight into the stereochemistry of enantioselectivity
Biochemistry
41
9410-9417
2002
Geobacillus stearothermophilus (Q45515), Geobacillus stearothermophilus, Geobacillus stearothermophilus SD1 (Q45515)
Abendroth, J.; Niefind, K.; Schomburg, D.
X-ray structure of a dihydropyrimidinase from Thermus sp. at 1.3 A resolution
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Thermus sp. (Q7SIE9), Thermus sp.
Slomka, C.; Zhong, S.; Fellinger, A.; Engel, U.; Syldatk, C.; Braese, S.; Rudat, J.
Chemical synthesis and enzymatic, stereoselective hydrolysis of a functionalized dihydropyrimidine for the synthesis of beta-amino acids
AMB Express
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85
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Arthrobacter crystallopoietes (Q84FR6), Arthrobacter crystallopoietes DSM 20117 (Q84FR6)
Xu, G.C.; Li, L.; Han, R.Z.; Dong, J.J.; Ni, Y.
Characterization and soluble expression of D-hydantoinase from Pseudomonas fluorescens for the synthesis of D-amino acids
Appl. Biochem. Biotechnol.
179
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2016
Pseudomonas fluorescens (S5MPT0), Pseudomonas fluorescens, Pseudomonas fluorescens CGMCC 1.1802 (S5MPT0)
Tzeng, C.T.; Huang, Y.H.; Huang, C.Y.
Crystal structure of dihydropyrimidinase from Pseudomonas aeruginosa PAO1 Insights into the molecular basis of formation of a dimer
Biochem. Biophys. Res. Commun.
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2016
Pseudomonas aeruginosa (Q9I676), Pseudomonas aeruginosa ATCC 15692 (Q9I676), Pseudomonas aeruginosa 1C (Q9I676), Pseudomonas aeruginosa PRS 101 (Q9I676), Pseudomonas aeruginosa DSM 22644 (Q9I676), Pseudomonas aeruginosa CIP 104116 (Q9I676), Pseudomonas aeruginosa LMG 12228 (Q9I676), Pseudomonas aeruginosa JCM 14847 (Q9I676)
Cheng, J.H.; Huang, Y.H.; Lin, J.J.; Huang, C.Y.
Crystal structures of monometallic dihydropyrimidinase and the human dihydroorotase domain K1556A mutant reveal no lysine carbamylation within the active site
Biochem. Biophys. Res. Commun.
505
439-444
2018
Tetraodon nigroviridis, Pseudomonas aeruginosa (Q9I676), Pseudomonas aeruginosa, Pseudomonas aeruginosa ATCC 15692 (Q9I676), Pseudomonas aeruginosa 1C (Q9I676), Pseudomonas aeruginosa PRS 101 (Q9I676), Pseudomonas aeruginosa DSM 22644 (Q9I676), Pseudomonas aeruginosa CIP 104116 (Q9I676), Pseudomonas aeruginosa LMG 12228 (Q9I676), Pseudomonas aeruginosa JCM 14847 (Q9I676)
Cheng, J.H.; Huang, C.C.; Huang, Y.H.; Huang, C.Y.
Structural basis for pH-dependent oligomerization of dihydropyrimidinase from Pseudomonas aeruginosa PAO1
Bioinorg. Chem. Appl.
2018
9564391
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Pseudomonas aeruginosa (Q9I676), Pseudomonas aeruginosa, Pseudomonas aeruginosa ATCC 15692 (Q9I676), Pseudomonas aeruginosa 1C (Q9I676), Pseudomonas aeruginosa PRS 101 (Q9I676), Pseudomonas aeruginosa DSM 22644 (Q9I676), Pseudomonas aeruginosa CIP 104116 (Q9I676), Pseudomonas aeruginosa LMG 12228 (Q9I676), Pseudomonas aeruginosa JCM 14847 (Q9I676)
Jin, Y.; Li, Y.; Sun, W.; Fan, S.; Feng, X.; Wang, K.; He, W.; Yang, Z.
The whole-cell immobilization of D-hydantoinase-engineered Escherichia coli for D-CpHPG biosynthesis
Electron. J. Biotechnol.
21
43-48
2016
Streptomyces sp.
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Huang, C.Y.
Inhibition of a putative dihydropyrimidinase from Pseudomonas aeruginosa PAO1 by flavonoids and substrates of cyclic amidohydrolases
PLoS ONE
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e0127634
2015
Pseudomonas aeruginosa (Q9I676), Pseudomonas aeruginosa ATCC 15692 (Q9I676), Pseudomonas aeruginosa 1C (Q9I676), Pseudomonas aeruginosa PRS 101 (Q9I676), Pseudomonas aeruginosa DSM 22644 (Q9I676), Pseudomonas aeruginosa CIP 104116 (Q9I676), Pseudomonas aeruginosa LMG 12228 (Q9I676), Pseudomonas aeruginosa JCM 14847 (Q9I676)
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